Academic Journal
Cell geometry, signal dampening, and a bimodal transcriptional response underlie the spatial precision of an ERK-mediated embryonic induction.
| Τίτλος: | Cell geometry, signal dampening, and a bimodal transcriptional response underlie the spatial precision of an ERK-mediated embryonic induction. |
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| Συγγραφείς: | Williaume, Géraldine, de Buyl, S., Sirour, Cathy, Haupaix, Nicolas, Bettoni, Rossana, Imai, Kaoru S, Satou, Yutaka, Dupont, Geneviève, Hudson, Clare, Yasuo, Hitoyoshi |
| Πηγή: | Developmental cell, 56 (21 |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| Θεματικοί όροι: | Sciences bio-médicales et agricoles, Animals, Body Patterning -- genetics, Cell Differentiation -- genetics -- physiology, Ciona intestinalis -- cytology -- embryology, Ectoderm -- cytology, Embryo, Nonmammalian -- metabolism, Embryonic Development -- physiology, Embryonic Induction -- physiology, Fibroblast Growth Factors -- metabolism, Gene Expression Regulation, Developmental -- physiology, Transcription Factors -- metabolism, ERF, FGF, Otx, ascidian, bimodal transcriptional response, ephrin-mediated signal dampening, gradual ERK response |
| Περιγραφή: | Precise control of lineage segregation is critical for the development of multicellular organisms, but our quantitative understanding of how variable signaling inputs are integrated to activate lineage-specific gene programs remains limited. Here, we show how precisely two out of eight ectoderm cells adopt neural fates in response to ephrin and FGF signals during ascidian neural induction. In each ectoderm cell, FGF signals activate ERK to a level that mirrors its cell contact surface with FGF-expressing mesendoderm cells. This gradual interpretation of FGF inputs is followed by a bimodal transcriptional response of the immediate early gene, Otx, resulting in its activation specifically in the neural precursors. At low levels of ERK, Otx is repressed by an ETS family transcriptional repressor, ERF2. Ephrin signals are critical for dampening ERK activation levels across ectoderm cells so that only neural precursors exhibit above-threshold levels, evade ERF repression, and "switch on" Otx transcription. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | 2 full-text file(s): application/pdf | application/pdf |
| Γλώσσα: | English |
| Relation: | uri/info:doi/10.1016/j.devcel.2021.09.025; uri/info:pmid/34672970; uri/info:scp/85119989310; https://dipot.ulb.ac.be/dspace/bitstream/2013/336695/5/Williaume_et_al2021.pdf; https://dipot.ulb.ac.be/dspace/bitstream/2013/336695/1/elsevier_320339.pdf |
| Διαθεσιμότητα: | https://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/336695 https://dipot.ulb.ac.be/dspace/bitstream/2013/336695/5/Williaume_et_al2021.pdf https://dipot.ulb.ac.be/dspace/bitstream/2013/336695/1/elsevier_320339.pdf |
| Αριθμός Καταχώρησης: | edsbas.DAD36EEC |
| Βάση Δεδομένων: | BASE |
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