Review
Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS):A Narrative Review of Its Clinical Relevance and Biomarker Potential
| Τίτλος: | Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS):A Narrative Review of Its Clinical Relevance and Biomarker Potential |
|---|---|
| Συγγραφείς: | Brantlov, Steven, Ward, Leigh C, Isidor, Søren, Hvas, Christian Lodberg, Rud, Charlotte Lock, Jødal, Lars |
| Πηγή: | Brantlov, S, Ward, L C, Isidor, S, Hvas, C L, Rud, C L & Jødal, L 2025, 'Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS) : A Narrative Review of Its Clinical Relevance and Biomarker Potential', Sensors (Basel, Switzerland), vol. 25, no. 14, 4362. https://doi.org/10.3390/s25144362 |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| Θεματικοί όροι: | Biomarkers, Cell Membrane/chemistry, Clinical Relevance, Dielectric Spectroscopy/methods, Electric Capacitance, Humans, cells, bioimpedance, electrical impedance, biomarker, membrane capacitance, bioimpedance spectroscopy |
| Περιγραφή: | Cell membrane capacitance (Cm) is a potential biomarker that reflects the structural and functional integrity of cell membranes. It is essential for physiological processes such as signal transduction, ion transport, and cellular homeostasis. In clinical practice, Cm can be determined using bioimpedance spectroscopy (BIS), a non-invasive technique for analysing the intrinsic electrical properties of biological tissues across a range of frequencies. Cm may be relevant in various clinical fields, where high capacitance is associated with healthy and intact membranes, while low capacitance indicates cellular damage or disease. Despite its promise as a prognostic indicator, several knowledge gaps limit the broader clinical application of Cm. These include variability in measurement techniques (e.g., electrode placement, frequency selection), the lack of standardised measurement protocols, uncertainty on how Cm is related to pathology, and the relatively low amount of Cm research. By addressing these gaps, Cm may become a valuable tool for examining cellular health, early disease detection, and evaluating treatment efficacy in clinical practice. This review explores the fundamental principles of Cm measured with the BIS technique, its mathematical basis and relationship to the biophysical Cole model, and its potential clinical applications. It identifies current gaps in our knowledge and outlines future research directions to enhance the understanding and use of Cm. For example, Cm has shown promise in identifying membrane degradation in sepsis, predicting malnutrition in anorexia nervosa, and as a prognostic factor in cancer. |
| Τύπος εγγράφου: | review |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1424-8220 1424-8239 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40732489; info:eu-repo/semantics/altIdentifier/pissn/1424-8220; info:eu-repo/semantics/altIdentifier/eissn/1424-8239 |
| DOI: | 10.3390/s25144362 |
| Διαθεσιμότητα: | https://vbn.aau.dk/da/publications/d3fd7c20-f1fa-49f9-8bcb-3dcde8d9982b https://doi.org/10.3390/s25144362 https://vbn.aau.dk/ws/files/811070125/Brantlov_et_al_2025_Cell_Membrane_Capacitance_Cm_Measured_by_Bioimpedance_Spectroscopy_BIS_.pdf https://www.scopus.com/pages/publications/105011501419 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.DAACEA5B |
| Βάση Δεδομένων: | BASE |
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| Items | – Name: Title Label: Title Group: Ti Data: Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS):A Narrative Review of Its Clinical Relevance and Biomarker Potential – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Brantlov%2C+Steven%22">Brantlov, Steven</searchLink><br /><searchLink fieldCode="AR" term="%22Ward%2C+Leigh+C%22">Ward, Leigh C</searchLink><br /><searchLink fieldCode="AR" term="%22Isidor%2C+Søren%22">Isidor, Søren</searchLink><br /><searchLink fieldCode="AR" term="%22Hvas%2C+Christian+Lodberg%22">Hvas, Christian Lodberg</searchLink><br /><searchLink fieldCode="AR" term="%22Rud%2C+Charlotte+Lock%22">Rud, Charlotte Lock</searchLink><br /><searchLink fieldCode="AR" term="%22Jødal%2C+Lars%22">Jødal, Lars</searchLink> – Name: TitleSource Label: Source Group: Src Data: Brantlov, S, Ward, L C, Isidor, S, Hvas, C L, Rud, C L & Jødal, L 2025, 'Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS) : A Narrative Review of Its Clinical Relevance and Biomarker Potential', Sensors (Basel, Switzerland), vol. 25, no. 14, 4362. https://doi.org/10.3390/s25144362 – Name: DatePubCY Label: Publication Year Group: Date Data: 2025 – Name: Subset Label: Collection Group: HoldingsInfo Data: Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Membrane%2Fchemistry%22">Cell Membrane/chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+Relevance%22">Clinical Relevance</searchLink><br /><searchLink fieldCode="DE" term="%22Dielectric+Spectroscopy%2Fmethods%22">Dielectric Spectroscopy/methods</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+Capacitance%22">Electric Capacitance</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22cells%22">cells</searchLink><br /><searchLink fieldCode="DE" term="%22bioimpedance%22">bioimpedance</searchLink><br /><searchLink fieldCode="DE" term="%22electrical+impedance%22">electrical impedance</searchLink><br /><searchLink fieldCode="DE" term="%22biomarker%22">biomarker</searchLink><br /><searchLink fieldCode="DE" term="%22membrane+capacitance%22">membrane capacitance</searchLink><br /><searchLink fieldCode="DE" term="%22bioimpedance+spectroscopy%22">bioimpedance spectroscopy</searchLink> – Name: Abstract Label: Description Group: Ab Data: Cell membrane capacitance (Cm) is a potential biomarker that reflects the structural and functional integrity of cell membranes. It is essential for physiological processes such as signal transduction, ion transport, and cellular homeostasis. In clinical practice, Cm can be determined using bioimpedance spectroscopy (BIS), a non-invasive technique for analysing the intrinsic electrical properties of biological tissues across a range of frequencies. Cm may be relevant in various clinical fields, where high capacitance is associated with healthy and intact membranes, while low capacitance indicates cellular damage or disease. Despite its promise as a prognostic indicator, several knowledge gaps limit the broader clinical application of Cm. These include variability in measurement techniques (e.g., electrode placement, frequency selection), the lack of standardised measurement protocols, uncertainty on how Cm is related to pathology, and the relatively low amount of Cm research. By addressing these gaps, Cm may become a valuable tool for examining cellular health, early disease detection, and evaluating treatment efficacy in clinical practice. This review explores the fundamental principles of Cm measured with the BIS technique, its mathematical basis and relationship to the biophysical Cole model, and its potential clinical applications. It identifies current gaps in our knowledge and outlines future research directions to enhance the understanding and use of Cm. For example, Cm has shown promise in identifying membrane degradation in sepsis, predicting malnutrition in anorexia nervosa, and as a prognostic factor in cancer. – Name: TypeDocument Label: Document Type Group: TypDoc Data: review – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1424-8220<br />1424-8239 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: info:eu-repo/semantics/altIdentifier/pmid/40732489; info:eu-repo/semantics/altIdentifier/pissn/1424-8220; info:eu-repo/semantics/altIdentifier/eissn/1424-8239 – Name: DOI Label: DOI Group: ID Data: 10.3390/s25144362 – Name: URL Label: Availability Group: URL Data: https://vbn.aau.dk/da/publications/d3fd7c20-f1fa-49f9-8bcb-3dcde8d9982b<br />https://doi.org/10.3390/s25144362<br />https://vbn.aau.dk/ws/files/811070125/Brantlov_et_al_2025_Cell_Membrane_Capacitance_Cm_Measured_by_Bioimpedance_Spectroscopy_BIS_.pdf<br />https://www.scopus.com/pages/publications/105011501419 – Name: Copyright Label: Rights Group: Cpyrght Data: info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ – Name: AN Label: Accession Number Group: ID Data: edsbas.DAACEA5B |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/s25144362 Languages: – Text: English Subjects: – SubjectFull: Biomarkers Type: general – SubjectFull: Cell Membrane/chemistry Type: general – SubjectFull: Clinical Relevance Type: general – SubjectFull: Dielectric Spectroscopy/methods Type: general – SubjectFull: Electric Capacitance Type: general – SubjectFull: Humans Type: general – SubjectFull: cells Type: general – SubjectFull: bioimpedance Type: general – SubjectFull: electrical impedance Type: general – SubjectFull: biomarker Type: general – SubjectFull: membrane capacitance Type: general – SubjectFull: bioimpedance spectroscopy Type: general Titles: – TitleFull: Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS):A Narrative Review of Its Clinical Relevance and Biomarker Potential Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brantlov, Steven – PersonEntity: Name: NameFull: Ward, Leigh C – PersonEntity: Name: NameFull: Isidor, Søren – PersonEntity: Name: NameFull: Hvas, Christian Lodberg – PersonEntity: Name: NameFull: Rud, Charlotte Lock – PersonEntity: Name: NameFull: Jødal, Lars IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 14248220 – Type: issn-print Value: 14248239 – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: Brantlov, S, Ward, L C, Isidor, S, Hvas, C L, Rud, C L & Jødal, L 2025, 'Cell Membrane Capacitance (C m ) Measured by Bioimpedance Spectroscopy (BIS) : A Narrative Review of Its Clinical Relevance and Biomarker Potential', Sensors (Basel, Switzerland), vol. 25, no. 14, 4362. https://doi.org/10.3390/s25144362 Type: main |
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