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Naming Genes for Dystonia: DYT-z or Ditzy?

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Τίτλος: Naming Genes for Dystonia: DYT-z or Ditzy?
Συγγραφείς: Mencacci, Niccolo E., Jinnah, H. A.
Έτος έκδοσης: 2019
Συλλογή: Columbia University: Academic Commons
Θεματικοί όροι: Dystonia, Human chromosomes--Nomenclature, Human genetics--Variation, Movement disorders, Neurology
Περιγραφή: Dystonias are a clinically and etiologically diverse group of disorders. Numerous genes have now been associated with different dystonia syndromes, and multiple strategies have been proposed for how these genes should be lumped and split into meaningful categories. The traditional approach has been based on the Human Genome Organization’s plan for naming genetic loci for all disorders. For dystonia this involves a DYT prefix followed by a number (e.g., DYT1, DYT2, DYT3, etc.). A more recently proposed approach involves assigning multiple prefixes according to the main elements of the phenotype (e.g., DYT, PARK, CHOR, TREM, etc.) followed by the name of the responsible gene. This article describes these nomenclature systems and summarizes some of their limitations. We focus on dystonia as an example, although the concepts may be applied to all movement disorders.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.7916/d8-2q02-nq03
Διαθεσιμότητα: https://doi.org/10.7916/d8-2q02-nq03
Αριθμός Καταχώρησης: edsbas.D9D69073
Βάση Δεδομένων: BASE
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  Data: Naming Genes for Dystonia: DYT-z or Ditzy?
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  Data: <searchLink fieldCode="AR" term="%22Mencacci%2C+Niccolo+E%2E%22">Mencacci, Niccolo E.</searchLink><br /><searchLink fieldCode="AR" term="%22Jinnah%2C+H%2E+A%2E%22">Jinnah, H. A.</searchLink>
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  Data: 2019
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  Data: Columbia University: Academic Commons
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  Data: <searchLink fieldCode="DE" term="%22Dystonia%22">Dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Human+chromosomes--Nomenclature%22">Human chromosomes--Nomenclature</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetics--Variation%22">Human genetics--Variation</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%22">Neurology</searchLink>
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  Data: Dystonias are a clinically and etiologically diverse group of disorders. Numerous genes have now been associated with different dystonia syndromes, and multiple strategies have been proposed for how these genes should be lumped and split into meaningful categories. The traditional approach has been based on the Human Genome Organization’s plan for naming genetic loci for all disorders. For dystonia this involves a DYT prefix followed by a number (e.g., DYT1, DYT2, DYT3, etc.). A more recently proposed approach involves assigning multiple prefixes according to the main elements of the phenotype (e.g., DYT, PARK, CHOR, TREM, etc.) followed by the name of the responsible gene. This article describes these nomenclature systems and summarizes some of their limitations. We focus on dystonia as an example, although the concepts may be applied to all movement disorders.
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  Data: 10.7916/d8-2q02-nq03
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