Academic Journal
Latent change-on-change between amyloid accumulation and cognitive decline
| Τίτλος: | Latent change-on-change between amyloid accumulation and cognitive decline |
|---|---|
| Συγγραφείς: | Klinger, HM, Healy, BC, Hanseeuw, BJ, Jones, RN, Boyle, R, Townsend, DL, Properzi, MJ, Coughlan, GT, Seto, M, Birkenbihl, C, Farrell, ME, Papp, KV, Chhatwal, JP, Yang, HS, Schultz, AP, Amariglio, RE, Jacobs, HIL, Price, JC, Johnson, KA, Rentz, DM, Sperling, RA, Buckley, RF |
| Στοιχεία εκδότη: | Wiley |
| Έτος έκδοσης: | 2024 |
| Συλλογή: | The University of Melbourne: Digital Repository |
| Περιγραφή: | INTRODUCTION: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. METHODS: A series of bivariate latent change score models (LCSM) examined the relationship between changes in 11C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS). RESULTS: Aβ accumulation was associated with subsequent cognitive decline beyond the effects of cross-sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross-sectional tau-PET and cognitive intercept/slope. DISCUSSION: Short-term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross-sectional Aβ and MTL tau. HIGHLIGHTS: Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau-PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| ISSN: | 1552-5260 |
| Relation: | https://hdl.handle.net/11343/359180 |
| Διαθεσιμότητα: | https://hdl.handle.net/11343/359180 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0 ; CC BY-NC |
| Αριθμός Καταχώρησης: | edsbas.D9CFF429 |
| Βάση Δεδομένων: | BASE |
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