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Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency

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Τίτλος: Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency
Συγγραφείς: Huang, Yaoqi, Hu, Chuan, Ye, Haifeng, Luo, Ruichen, Fu, Xinxin, Li, Xiaoyan, Huang, Jian, Chen, Weiyun, Zheng, Yuehui
Συνεισφορές: Nanchang University, Natural Science Foundation of Jiangxi Province, National Natural Science Foundation of China
Πηγή: Journal of Immunology Research ; volume 2019, page 1-7 ; ISSN 2314-8861 2314-7156
Στοιχεία εκδότη: Wiley
Έτος έκδοσης: 2019
Συλλογή: Wiley Online Library (Open Access Articles via Crossref)
Περιγραφή: The normal function of ovaries, along with the secretion of sex hormones, is among the most important endocrine factors that maintain the female sexual characteristics and promote follicular development and ovulation. Premature ovarian insufficiency (POI) is a common cause in the etiology of female infertility. It is defined as the loss of ovarian function before the age of 40. The characteristics of POI are menstrual disorders, including amenorrhea and delayed menstruation, accompanied by a raised gonadotrophin level and decreased estradiol level. Inflammatory aging is a new concept in the research field of aging. It refers to a chronic and low-degree proinflammatory state which occurs with increasing age. Inflammatory aging is closely associated with multiple diseases, as excessive inflammation can induce the inflammatory lesions in certain organs of the body. In recent years, studies have shown that inflammatory aging plays a significant role in the pathogenesis of POI. This paper begins with the pathogenesis of inflammatory aging and summarizes the relationship between inflammatory aging and premature ovarian insufficiency in a comprehensive way, as well as discussing the new diagnostic and therapeutic methods of POI.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.1155/2019/8069898
Διαθεσιμότητα: https://doi.org/10.1155/2019/8069898
http://downloads.hindawi.com/journals/jir/2019/8069898.pdf
http://downloads.hindawi.com/journals/jir/2019/8069898.xml
Rights: http://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.D64B083C
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.1155/2019/8069898#
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  Data: Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency
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  Data: <searchLink fieldCode="AR" term="%22Huang%2C+Yaoqi%22">Huang, Yaoqi</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+Chuan%22">Hu, Chuan</searchLink><br /><searchLink fieldCode="AR" term="%22Ye%2C+Haifeng%22">Ye, Haifeng</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Ruichen%22">Luo, Ruichen</searchLink><br /><searchLink fieldCode="AR" term="%22Fu%2C+Xinxin%22">Fu, Xinxin</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaoyan%22">Li, Xiaoyan</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Jian%22">Huang, Jian</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Weiyun%22">Chen, Weiyun</searchLink><br /><searchLink fieldCode="AR" term="%22Zheng%2C+Yuehui%22">Zheng, Yuehui</searchLink>
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  Data: Nanchang University<br />Natural Science Foundation of Jiangxi Province<br />National Natural Science Foundation of China
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  Data: Journal of Immunology Research ; volume 2019, page 1-7 ; ISSN 2314-8861 2314-7156
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  Data: The normal function of ovaries, along with the secretion of sex hormones, is among the most important endocrine factors that maintain the female sexual characteristics and promote follicular development and ovulation. Premature ovarian insufficiency (POI) is a common cause in the etiology of female infertility. It is defined as the loss of ovarian function before the age of 40. The characteristics of POI are menstrual disorders, including amenorrhea and delayed menstruation, accompanied by a raised gonadotrophin level and decreased estradiol level. Inflammatory aging is a new concept in the research field of aging. It refers to a chronic and low-degree proinflammatory state which occurs with increasing age. Inflammatory aging is closely associated with multiple diseases, as excessive inflammation can induce the inflammatory lesions in certain organs of the body. In recent years, studies have shown that inflammatory aging plays a significant role in the pathogenesis of POI. This paper begins with the pathogenesis of inflammatory aging and summarizes the relationship between inflammatory aging and premature ovarian insufficiency in a comprehensive way, as well as discussing the new diagnostic and therapeutic methods of POI.
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