Academic Journal
Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy body diseases. An exploratory study
| Τίτλος: | Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy body diseases. An exploratory study |
|---|---|
| Συγγραφείς: | Del Percio C., Lizio R., Lopez S., Noce G., Jakhar D., Carpi M., Bolukbas B., Soricelli A., Salvatore M., Guntekin B., Yener G., Massa F., Arnaldi D., Fama F., Pardini M., Ferri R., Salerni M., Lanuzza B., Stocchi F., Vacca L., Coletti C., Marizzoni M., Taylor J. P., Hanoglu L., Helvaci Yilmaz N., Kiyi I., Ozbek-Isbitiren Y., Frisoni G. B., Cuoco S., Barone P., D'Anselmo A., Bonanni L., Biundo R., D'Antonio F., Bruno G., Giubilei F., De Pandis F., Rotondo R., Antonini A., Babiloni C. |
| Συνεισφορές: | Del Percio, C., Lizio, R., Lopez, S., Noce, G., Jakhar, D., Carpi, M., Bolukbas, B., Soricelli, A., Salvatore, M., Guntekin, B., Yener, G., Massa, F., Arnaldi, D., Fama, F., Pardini, M., Ferri, R., Salerni, M., Lanuzza, B., Stocchi, F., Vacca, L., Coletti, C., Marizzoni, M., Taylor, J. P., Hanoglu, L., Helvaci Yilmaz, N., Kiyi, I., Ozbek-Isbitiren, Y., Frisoni, G. B., Cuoco, S., Barone, P., D'Anselmo, A., Bonanni, L., Biundo, R., D'Antonio, F., Bruno, G., Giubilei, F., De Pandis, F., Rotondo, R., Antonini, A., Babiloni, C. |
| Στοιχεία εκδότη: | ACADEMIC PRESS INC ELSEVIER SCIENCE 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Sapienza Università di Roma: CINECA IRIS |
| Θεματικοί όροι: | exact low-resolution brain electromagnetic source tomography (eloreta), Lewy body dementia (dlb), parkinson's disease dementia (pdd), resting-state electroencephalographic (eeg) rhythm, sex |
| Περιγραφή: | Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8-10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39855475; info:eu-repo/semantics/altIdentifier/wos/WOS:001416306300001; volume:206; numberofpages:17; journal:NEUROBIOLOGY OF DISEASE; https://hdl.handle.net/11573/1734436 |
| DOI: | 10.1016/j.nbd.2025.106807 |
| Διαθεσιμότητα: | https://hdl.handle.net/11573/1734436 https://doi.org/10.1016/j.nbd.2025.106807 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.D20C4035 |
| Βάση Δεδομένων: | BASE |
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