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Synthesis and biodistribution of Tc-99m-carbonyltechnetium-labeled fatty acids

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Τίτλος: Synthesis and biodistribution of Tc-99m-carbonyltechnetium-labeled fatty acids
Συγγραφείς: Chu, TW, Zhang, Y, Liu, XQ, Wang, Y, Hu, SW, Wang, XY
Συνεισφορές: Chu, TW (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.
Πηγή: EI ; PubMed ; SCI
Στοιχεία εκδότη: 应用辐射与同位素
Έτος έκδοσης: 2004
Συλλογή: Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
Θεματικοί όροι: fatty acid, myocardial metabolism imaging, carbonyl technetium, Tween-80, COMPLEXES, TC-99M, TECHNETIUM, CHEMISTRY, CRYSTAL, LIGAND
Περιγραφή: In order to image myocardial metabolism, Tc-99m(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-inudazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of Tc-99m(CO)(3)-IUA and Tc-99m(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging. (C) 2004 Elsevier Ltd. All rights reserved. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000221315600009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging ; SCI(E) ; EI ; PubMed ; 21 ; ARTICLE ; 6 ; 845-850 ; 60
Τύπος εγγράφου: journal/newspaper
Γλώσσα: English
Relation: 676846; https://hdl.handle.net/20.500.11897/150262; WOS:000221315600009
DOI: 10.1016/j.apradiso.2004.02.006
Διαθεσιμότητα: https://hdl.handle.net/20.500.11897/150262
https://doi.org/10.1016/j.apradiso.2004.02.006
Αριθμός Καταχώρησης: edsbas.CF8C4CEC
Βάση Δεδομένων: BASE
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  Data: Synthesis and biodistribution of Tc-99m-carbonyltechnetium-labeled fatty acids
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  Data: <searchLink fieldCode="AR" term="%22Chu%2C+TW%22">Chu, TW</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Y%22">Zhang, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+XQ%22">Liu, XQ</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Y%22">Wang, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+SW%22">Hu, SW</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+XY%22">Wang, XY</searchLink>
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  Data: Chu, TW (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.<br />Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.
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  Data: In order to image myocardial metabolism, Tc-99m(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-inudazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of Tc-99m(CO)(3)-IUA and Tc-99m(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging. (C) 2004 Elsevier Ltd. All rights reserved. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000221315600009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging ; SCI(E) ; EI ; PubMed ; 21 ; ARTICLE ; 6 ; 845-850 ; 60
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