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The mechanical response of vinculin

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Τίτλος: The mechanical response of vinculin
Συγγραφείς: Liu, Xuyao, Liu, Jingzhun, Wang, Yinan, Yao, Mingxi, Baker, Karen B, Klapholz, Benjamin, Brown, Nicholas H, Goult, Benjamin T, Yan, Jie
Στοιχεία εκδότη: American Association for the Advancement of Science (AAAS)
Έτος έκδοσης: 2025
Συλλογή: The University of Liverpool Repository
Περιγραφή: Vinculin is a mechanosensitive adaptor that links actin to cell-matrix and cell-cell adhesions. Known as a mechanoeffector, it is recruited to adhesion sites under force via mechanotransducers talin and α-catenin. Here, we examine vinculin’s mechanical properties to assess its role as a mechanotransducer. We find that at physiological loading rates, vinculin domains unfold at forces of 5 to 15 pN and refold rapidly when forces drop to 1 pN. This behavior is reminiscent of force-dependent switches in talin and α-catenin, suggesting vinculin domains also function as molecular switches. Unfolding induces large extension changes up to 150 nm in steps of 20 to 30 nm. These findings reveal that vinculin exhibits a previously unrecognized mechanical response, with dynamic folding/ unfolding under force acting as a buffering mechanism. Given its role as a scaffold for many proteins, this mechanosensitive behavior supports a model where vinculin functions directly as a mechanotransducer, recruiting binding partners in a force-dependent manner.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
ISSN: 2375-2548
Relation: https://livrepository.liverpool.ac.uk/3195140/1/2025_Liu_SciAdv.pdf; Liu, Xuyao, Liu, Jingzhun, Wang, Yinan, Yao, Mingxi, Baker, Karen B, Klapholz, Benjamin, Brown, Nicholas H, Goult, Benjamin T orcid:0000-0002-3438-2807 and Yan, Jie (2025) The mechanical response of vinculin SCIENCE ADVANCES, 11 (44). pp. 1-10. ISSN 2375-2548, 2375-2548
DOI: 10.1126/sciadv.ady6949
Διαθεσιμότητα: https://livrepository.liverpool.ac.uk/3195140/
https://doi.org/10.1126/sciadv.ady6949
https://livrepository.liverpool.ac.uk/3195140/1/2025_Liu_SciAdv.pdf
Αριθμός Καταχώρησης: edsbas.C9845EAE
Βάση Δεδομένων: BASE
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  Data: Vinculin is a mechanosensitive adaptor that links actin to cell-matrix and cell-cell adhesions. Known as a mechanoeffector, it is recruited to adhesion sites under force via mechanotransducers talin and α-catenin. Here, we examine vinculin’s mechanical properties to assess its role as a mechanotransducer. We find that at physiological loading rates, vinculin domains unfold at forces of 5 to 15 pN and refold rapidly when forces drop to 1 pN. This behavior is reminiscent of force-dependent switches in talin and α-catenin, suggesting vinculin domains also function as molecular switches. Unfolding induces large extension changes up to 150 nm in steps of 20 to 30 nm. These findings reveal that vinculin exhibits a previously unrecognized mechanical response, with dynamic folding/ unfolding under force acting as a buffering mechanism. Given its role as a scaffold for many proteins, this mechanosensitive behavior supports a model where vinculin functions directly as a mechanotransducer, recruiting binding partners in a force-dependent manner.
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  Data: https://livrepository.liverpool.ac.uk/3195140/1/2025_Liu_SciAdv.pdf; Liu, Xuyao, Liu, Jingzhun, Wang, Yinan, Yao, Mingxi, Baker, Karen B, Klapholz, Benjamin, Brown, Nicholas H, Goult, Benjamin T orcid:0000-0002-3438-2807 and Yan, Jie (2025) The mechanical response of vinculin SCIENCE ADVANCES, 11 (44). pp. 1-10. ISSN 2375-2548, 2375-2548
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