Academic Journal
Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study.
| Title: | Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study. |
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| Authors: | Ng, Wee-Han, Bath, Michael F, Amoako, Joachim, Kohler, Katharina, Baderhabusha, Daniel U, Cáceres, Eder, Nuño-Guzmán, Carlos M, Moonesinghe, Ramani, Hobbs, Laura, Smith, Brandon G, Weiser, Thomas G, Hardcastle, Timothy C, Perkins, Zane B, Bashford, Tom, GOAL-Trauma Collaborative |
| Publisher Information: | Elsevier Department of Engineering Student //doi.org/10.1016/j.eclinm.2026.103814 |
| Publication Year: | 2026 |
| Collection: | Apollo - University of Cambridge Repository |
| Subject Terms: | Blood products, Global surgery, Trauma |
| Description: | BACKGROUND: Haemorrhage remains the leading cause of death in patients with abdominal trauma. However, variation remains globally in the standards of transfusion practice. The aim of this study was to characterise global pre-operative transfusion practices for patients undergoing trauma laparotomy and identify any associations between transfusion strategies and mortality. METHODS: This was a planned secondary analysis of the Global Outcomes After Laparotomy for Trauma (GOAL-Trauma) study, an international multicentre prospective observational study conducted at 187 hospital centres across 51 countries. Patients of any age with a blunt or penetrating traumatic injury who underwent a laparotomy within 5 days of presentation were eligible. Patients were excluded if they were undergoing a repeat laparotomy at the recruiting centre within 30 days of the index procedure. Eligible participants were recruited between April 1, 2024, and Dec 31, 2024 during select 30-day periods and were followed up until discharge, death, or 30 days post-operatively (if still hospitalised), whichever came first. Pre-operative blood product usage was recorded from time of injury until index procedure. Countries were stratified by Human Development Index (HDI) and the primary outcome was post-operative in-hospital 30-day mortality. Comparative regression analyses between blood component groups were performed, comparing high versus low transfusion ratios of fresh frozen plasma (FFP) to packed red blood cells (PRBC). The GOAL-Trauma study was registered with ClinicalTrials.gov, NCT06180668. FINDINGS: Overall, 721 (40.8%) of 1768 patients received any type of pre-operative blood product. Those in the upper HDI tertile received the highest proportions of blood components, across PRBC, FFP, and platelets (p < 0.0001). Whole blood usage was nearly double in the lower HDI tertile compared to middle and upper HDI tertiles (p < 0.0001). Tranexamic acid use was low across all HDI tertiles (529 of 1768 patients, 29.9%). No difference in overall ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf; image/png; application/msword |
| Language: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/398294; https://doi.org/10.17863/CAM.127182 |
| DOI: | 10.17863/CAM.127182 |
| Availability: | https://www.repository.cam.ac.uk/handle/1810/398294 https://doi.org/10.17863/CAM.127182 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.C6B658C9 |
| Database: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://www.repository.cam.ac.uk/handle/1810/398294# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ng%2C+Wee-Han%22">Ng, Wee-Han</searchLink><br /><searchLink fieldCode="AR" term="%22Bath%2C+Michael+F%22">Bath, Michael F</searchLink><br /><searchLink fieldCode="AR" term="%22Amoako%2C+Joachim%22">Amoako, Joachim</searchLink><br /><searchLink fieldCode="AR" term="%22Kohler%2C+Katharina%22">Kohler, Katharina</searchLink><br /><searchLink fieldCode="AR" term="%22Baderhabusha%2C+Daniel+U%22">Baderhabusha, Daniel U</searchLink><br /><searchLink fieldCode="AR" term="%22Cáceres%2C+Eder%22">Cáceres, Eder</searchLink><br /><searchLink fieldCode="AR" term="%22Nuño-Guzmán%2C+Carlos+M%22">Nuño-Guzmán, Carlos M</searchLink><br /><searchLink fieldCode="AR" term="%22Moonesinghe%2C+Ramani%22">Moonesinghe, Ramani</searchLink><br /><searchLink fieldCode="AR" term="%22Hobbs%2C+Laura%22">Hobbs, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+Brandon+G%22">Smith, Brandon G</searchLink><br /><searchLink fieldCode="AR" term="%22Weiser%2C+Thomas+G%22">Weiser, Thomas G</searchLink><br /><searchLink fieldCode="AR" term="%22Hardcastle%2C+Timothy+C%22">Hardcastle, Timothy C</searchLink><br /><searchLink fieldCode="AR" term="%22Perkins%2C+Zane+B%22">Perkins, Zane B</searchLink><br /><searchLink fieldCode="AR" term="%22Bashford%2C+Tom%22">Bashford, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22GOAL-Trauma+Collaborative%22">GOAL-Trauma Collaborative</searchLink> – Name: Publisher Label: Publisher Information Group: PubInfo Data: Elsevier<br />Department of Engineering Student<br />//doi.org/10.1016/j.eclinm.2026.103814 – Name: DatePubCY Label: Publication Year Group: Date Data: 2026 – Name: Subset Label: Collection Group: HoldingsInfo Data: Apollo - University of Cambridge Repository – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Blood+products%22">Blood products</searchLink><br /><searchLink fieldCode="DE" term="%22Global+surgery%22">Global surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Trauma%22">Trauma</searchLink> – Name: Abstract Label: Description Group: Ab Data: BACKGROUND: Haemorrhage remains the leading cause of death in patients with abdominal trauma. However, variation remains globally in the standards of transfusion practice. The aim of this study was to characterise global pre-operative transfusion practices for patients undergoing trauma laparotomy and identify any associations between transfusion strategies and mortality. METHODS: This was a planned secondary analysis of the Global Outcomes After Laparotomy for Trauma (GOAL-Trauma) study, an international multicentre prospective observational study conducted at 187 hospital centres across 51 countries. Patients of any age with a blunt or penetrating traumatic injury who underwent a laparotomy within 5 days of presentation were eligible. Patients were excluded if they were undergoing a repeat laparotomy at the recruiting centre within 30 days of the index procedure. Eligible participants were recruited between April 1, 2024, and Dec 31, 2024 during select 30-day periods and were followed up until discharge, death, or 30 days post-operatively (if still hospitalised), whichever came first. Pre-operative blood product usage was recorded from time of injury until index procedure. Countries were stratified by Human Development Index (HDI) and the primary outcome was post-operative in-hospital 30-day mortality. Comparative regression analyses between blood component groups were performed, comparing high versus low transfusion ratios of fresh frozen plasma (FFP) to packed red blood cells (PRBC). The GOAL-Trauma study was registered with ClinicalTrials.gov, NCT06180668. FINDINGS: Overall, 721 (40.8%) of 1768 patients received any type of pre-operative blood product. Those in the upper HDI tertile received the highest proportions of blood components, across PRBC, FFP, and platelets (p < 0.0001). Whole blood usage was nearly double in the lower HDI tertile compared to middle and upper HDI tertiles (p < 0.0001). Tranexamic acid use was low across all HDI tertiles (529 of 1768 patients, 29.9%). No difference in overall ... – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf; image/png; application/msword – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.repository.cam.ac.uk/handle/1810/398294; https://doi.org/10.17863/CAM.127182 – Name: DOI Label: DOI Group: ID Data: 10.17863/CAM.127182 – Name: URL Label: Availability Group: URL Data: https://www.repository.cam.ac.uk/handle/1810/398294<br />https://doi.org/10.17863/CAM.127182 – Name: Copyright Label: Rights Group: Cpyrght Data: Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ – Name: AN Label: Accession Number Group: ID Data: edsbas.C6B658C9 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.17863/CAM.127182 Languages: – Text: English Subjects: – SubjectFull: Blood products Type: general – SubjectFull: Global surgery Type: general – SubjectFull: Trauma Type: general Titles: – TitleFull: Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ng, Wee-Han – PersonEntity: Name: NameFull: Bath, Michael F – PersonEntity: Name: NameFull: Amoako, Joachim – PersonEntity: Name: NameFull: Kohler, Katharina – PersonEntity: Name: NameFull: Baderhabusha, Daniel U – PersonEntity: Name: NameFull: Cáceres, Eder – PersonEntity: Name: NameFull: Nuño-Guzmán, Carlos M – PersonEntity: Name: NameFull: Moonesinghe, Ramani – PersonEntity: Name: NameFull: Hobbs, Laura – PersonEntity: Name: NameFull: Smith, Brandon G – PersonEntity: Name: NameFull: Weiser, Thomas G – PersonEntity: Name: NameFull: Hardcastle, Timothy C – PersonEntity: Name: NameFull: Perkins, Zane B – PersonEntity: Name: NameFull: Bashford, Tom – PersonEntity: Name: NameFull: GOAL-Trauma Collaborative IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2026 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa |
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