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Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study.

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Τίτλος: Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study.
Συγγραφείς: Kalbe, Elke, Rehberg, Sarah Petra, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker, Rüdiger, Oberschmidt, Carola, Witt, Karsten, Schmidt, Nele, Mollenhauer, Brit, Trenkwalder, Claudia, Spottke, Annika, Heber, Ines, Röske, Sandra, Wittchen, Hans-Ulrich, Riedel, Oliver, Dodel, Richard, Kronenbuerger, Martin, Schulz, Jörg B, Storch, Alexander, Linse, Katharina, Schneider, Christine, Gräber, Susanne, Liepelt-Scarfone, Inga
Πηγή: Journal of neurology, neurosurgery, and psychiatry 87(10), 1099-1105 (2016). doi:10.1136/jnnp-2016-313838
Στοιχεία εκδότη: BMJ Publishing Group
Έτος έκδοσης: 2016
Θεματικοί όροι: info:eu-repo/classification/ddc/610, Aged, Amnesia: classification, Amnesia: diagnosis, Amnesia: epidemiology, Amnesia: psychology, Cognitive Dysfunction: classification, Cognitive Dysfunction: diagnosis, Cognitive Dysfunction: epidemiology, Cognitive Dysfunction: psychology, Cross-Sectional Studies, Executive Function, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease: classification, Parkinson Disease: diagnosis, Parkinson Disease: epidemiology, Parkinson Disease: psychology, Prospective Studies
Θέμα γεωγραφικό: DE
Περιγραφή: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
ISSN: 2753-0485
2753-0477
0368-329X
0266-8637
1468-330X
0022-3050
Relation: info:eu-repo/semantics/altIdentifier/issn/2753-0485; info:eu-repo/semantics/altIdentifier/issn/2753-0477; info:eu-repo/semantics/altIdentifier/issn/0368-329X; info:eu-repo/semantics/altIdentifier/issn/0266-8637; info:eu-repo/semantics/altIdentifier/pmid/pmid:27401782; info:eu-repo/semantics/altIdentifier/issn/1468-330X; info:eu-repo/semantics/altIdentifier/issn/0022-3050; https://pub.dzne.de/record/138793
Διαθεσιμότητα: https://pub.dzne.de/record/138793
https://pub.dzne.de/search?p=id:%22DZNE-2020-05115%22
Rights: info:eu-repo/semantics/closedAccess
Αριθμός Καταχώρησης: edsbas.C550A73B
Βάση Δεδομένων: BASE
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  Data: Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study.
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  Data: Journal of neurology, neurosurgery, and psychiatry 87(10), 1099-1105 (2016). doi:10.1136/jnnp-2016-313838
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  Data: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.
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