Academic Journal
Προβολή σε EDS

The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model
Συγγραφείς: Yujie Li, Marjana Petrova, Alireza Gholipour, Hosen Kiat, Craig McLachlan
Έτος έκδοσης: 2025
Συλλογή: Torrens University Australia: Figshare
Θεματικοί όροι: Applications in health, aortic stiffness, carotid stiffness, computer simulation models
Περιγραφή: Increased aortic and carotid stiffness are independent predictors of adverse cardiovascular events. Arterial stiffness is not uniform across the arterial tree and its accurate assessment is challenging. The complex interactions and influence of aortic stiffness on carotid stiffness have not been investigated. The aim of this study was to evaluate the effect of aortic stiffness on carotid stiffness under physiological pressure conditions. A realistic patient-specific geometry was used based on magnetic resonance images obtained from the OsiriX library. The luminal aortic–carotid model was reconstructed from magnetic resonance images using 3D Slicer. A series of aortic stiffness simulations were performed at different regional aortic areas (levels). By applying variable Young's modulus to the aortic wall under two pulse pressure conditions, one could examine the deformation, compliance and von Mises stress between the aorta and carotid arteries. An increase of Young's modulus in an aortic area resulted in a notable difference in the mechanical properties of the aortic tree. Regional deformation, compliance and von Mises stress changes across the aorta and carotid arteries were noted with an increase of the aortic Young's modulus. Our results indicate that increased carotid stiffness may be associated with increased aortic stiffness. Large-scale clinical validation is warranted to examine the influence of aortic stiffness on carotid stiffness.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: unknown
Relation: https://figshare.com/articles/journal contribution/The_influence_of_aortic_stiffness_on_carotid_stiffness_computational_simulations_using_a_human_aorta_carotid_model/28181036
DOI: 10.25905/28181036.v1
Διαθεσιμότητα: https://doi.org/10.25905/28181036.v1
Rights: CC BY 4.0
Αριθμός Καταχώρησης: edsbas.C34C386F
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doi.org/10.25905/28181036.v1#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.C34C386F
RelevancyScore: 978
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 977.8095703125
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yujie+Li%22">Yujie Li</searchLink><br /><searchLink fieldCode="AR" term="%22Marjana+Petrova%22">Marjana Petrova</searchLink><br /><searchLink fieldCode="AR" term="%22Alireza+Gholipour%22">Alireza Gholipour</searchLink><br /><searchLink fieldCode="AR" term="%22Hosen+Kiat%22">Hosen Kiat</searchLink><br /><searchLink fieldCode="AR" term="%22Craig+McLachlan%22">Craig McLachlan</searchLink>
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Torrens University Australia: Figshare
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Applications+in+health%22">Applications in health</searchLink><br /><searchLink fieldCode="DE" term="%22aortic+stiffness%22">aortic stiffness</searchLink><br /><searchLink fieldCode="DE" term="%22carotid+stiffness%22">carotid stiffness</searchLink><br /><searchLink fieldCode="DE" term="%22computer+simulation+models%22">computer simulation models</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Increased aortic and carotid stiffness are independent predictors of adverse cardiovascular events. Arterial stiffness is not uniform across the arterial tree and its accurate assessment is challenging. The complex interactions and influence of aortic stiffness on carotid stiffness have not been investigated. The aim of this study was to evaluate the effect of aortic stiffness on carotid stiffness under physiological pressure conditions. A realistic patient-specific geometry was used based on magnetic resonance images obtained from the OsiriX library. The luminal aortic–carotid model was reconstructed from magnetic resonance images using 3D Slicer. A series of aortic stiffness simulations were performed at different regional aortic areas (levels). By applying variable Young's modulus to the aortic wall under two pulse pressure conditions, one could examine the deformation, compliance and von Mises stress between the aorta and carotid arteries. An increase of Young's modulus in an aortic area resulted in a notable difference in the mechanical properties of the aortic tree. Regional deformation, compliance and von Mises stress changes across the aorta and carotid arteries were noted with an increase of the aortic Young's modulus. Our results indicate that increased carotid stiffness may be associated with increased aortic stiffness. Large-scale clinical validation is warranted to examine the influence of aortic stiffness on carotid stiffness.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Language
  Label: Language
  Group: Lang
  Data: unknown
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://figshare.com/articles/journal contribution/The_influence_of_aortic_stiffness_on_carotid_stiffness_computational_simulations_using_a_human_aorta_carotid_model/28181036
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.25905/28181036.v1
– Name: URL
  Label: Availability
  Group: URL
  Data: https://doi.org/10.25905/28181036.v1
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: CC BY 4.0
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.C34C386F
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.C34C386F
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.25905/28181036.v1
    Languages:
      – Text: unknown
    Subjects:
      – SubjectFull: Applications in health
        Type: general
      – SubjectFull: aortic stiffness
        Type: general
      – SubjectFull: carotid stiffness
        Type: general
      – SubjectFull: computer simulation models
        Type: general
    Titles:
      – TitleFull: The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yujie Li
      – PersonEntity:
          Name:
            NameFull: Marjana Petrova
      – PersonEntity:
          Name:
            NameFull: Alireza Gholipour
      – PersonEntity:
          Name:
            NameFull: Hosen Kiat
      – PersonEntity:
          Name:
            NameFull: Craig McLachlan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1