Academic Journal
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians
| Τίτλος: | Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians |
|---|---|
| Συγγραφείς: | Chen, P, Takeuchi, F, Lee, JY, Li, H, Wu, JY, Liang, J, Long, J, Tabara, Y, Goodarzi, MO, Pereira, MA, Kim, YJ, Go, MJ, Stram, DO, Vithana, E, Khor, CC, Liu, J, Liao, J, Ye, X, Wang, Y, Lu, L, Young, TL, Lee, J, Thai, AC, Cheng, CY, Van Dam, RM, Friedlander, Y, Heng, CK, Koh, WP, Chen, CH, Chang, LC, Pan, WH, Qi, B, Isono, M, Zheng, W, Cai, Q, Gao, Y, Yamamoto, K, Ohnaka, K, Takayanagi, R, Kita, Y, Ueshima, H, Hsiung, CA, Cui, J, Sheu, WHH, Rotter, JI, Chen, YDI, Hsu, C, Okada, Y, Kubo, M, Takahashi, A, Tanaka, T, Van Rooij, FJA, Ganesh, SK, Huang, J, Huang, T, Yuan, J, Hwang, JY, Gross, MD, Assimes, TL, Miki, T, Shu, XO, Qi, L, Chen, YT, Lin, X, Aung, T, Wong, TY, Teo, YY, Kim, BJ, Kato, N, Tai, ES |
| Στοιχεία εκδότη: | American Diabetes Association |
| Έτος έκδοσης: | 2014 |
| Συλλογή: | The University of Melbourne: Digital Repository |
| Περιγραφή: | Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (<7.0 mmol/L) but elevated HbA1c (≥6.5%), 36.1% had HbA1c <6.5% after adjustment for these six variants. Our East Asian GWAS meta-analysis has identified novel variants associated with HbA1c as well as demonstrated that the effects of known variants are largely transferable across ethnic groups. Variants affecting erythrocyte parameters rather than glucose metabolism may be relevant to the use of HbA1c for diagnosing diabetes in these populations. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| ISSN: | 0012-1797 |
| Relation: | https://hdl.handle.net/11343/306278 |
| Διαθεσιμότητα: | https://hdl.handle.net/11343/306278 |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0 ; CC BY-NC-ND |
| Αριθμός Καταχώρησης: | edsbas.C24941AB |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://hdl.handle.net/11343/306278# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edsbas&genre=article&issn=00121797&ISBN=&volume=&issue=&date=20140101&spage=&pages=&title=Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians&atitle=Multiple%20nonglycemic%20genomic%20loci%20are%20newly%20associated%20with%20blood%20level%20of%20glycated%20hemoglobin%20in%20East%20Asians&aulast=Chen%2C%20P&id=DOI: Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
|---|---|
| Header | DbId: edsbas DbLabel: BASE An: edsbas.C24941AB RelevancyScore: 847 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 846.644287109375 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+P%22">Chen, P</searchLink><br /><searchLink fieldCode="AR" term="%22Takeuchi%2C+F%22">Takeuchi, F</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+JY%22">Lee, JY</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+H%22">Li, H</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+JY%22">Wu, JY</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+J%22">Liang, J</searchLink><br /><searchLink fieldCode="AR" term="%22Long%2C+J%22">Long, J</searchLink><br /><searchLink fieldCode="AR" term="%22Tabara%2C+Y%22">Tabara, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Goodarzi%2C+MO%22">Goodarzi, MO</searchLink><br /><searchLink fieldCode="AR" term="%22Pereira%2C+MA%22">Pereira, MA</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+YJ%22">Kim, YJ</searchLink><br /><searchLink fieldCode="AR" term="%22Go%2C+MJ%22">Go, MJ</searchLink><br /><searchLink fieldCode="AR" term="%22Stram%2C+DO%22">Stram, DO</searchLink><br /><searchLink fieldCode="AR" term="%22Vithana%2C+E%22">Vithana, E</searchLink><br /><searchLink fieldCode="AR" term="%22Khor%2C+CC%22">Khor, CC</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+J%22">Liu, J</searchLink><br /><searchLink fieldCode="AR" term="%22Liao%2C+J%22">Liao, J</searchLink><br /><searchLink fieldCode="AR" term="%22Ye%2C+X%22">Ye, X</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Y%22">Wang, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Lu%2C+L%22">Lu, L</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+TL%22">Young, TL</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+J%22">Lee, J</searchLink><br /><searchLink fieldCode="AR" term="%22Thai%2C+AC%22">Thai, AC</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng%2C+CY%22">Cheng, CY</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Dam%2C+RM%22">Van Dam, RM</searchLink><br /><searchLink fieldCode="AR" term="%22Friedlander%2C+Y%22">Friedlander, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Heng%2C+CK%22">Heng, CK</searchLink><br /><searchLink fieldCode="AR" term="%22Koh%2C+WP%22">Koh, WP</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+CH%22">Chen, CH</searchLink><br /><searchLink fieldCode="AR" term="%22Chang%2C+LC%22">Chang, LC</searchLink><br /><searchLink fieldCode="AR" term="%22Pan%2C+WH%22">Pan, WH</searchLink><br /><searchLink fieldCode="AR" term="%22Qi%2C+B%22">Qi, B</searchLink><br /><searchLink fieldCode="AR" term="%22Isono%2C+M%22">Isono, M</searchLink><br /><searchLink fieldCode="AR" term="%22Zheng%2C+W%22">Zheng, W</searchLink><br /><searchLink fieldCode="AR" term="%22Cai%2C+Q%22">Cai, Q</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Y%22">Gao, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Yamamoto%2C+K%22">Yamamoto, K</searchLink><br /><searchLink fieldCode="AR" term="%22Ohnaka%2C+K%22">Ohnaka, K</searchLink><br /><searchLink fieldCode="AR" term="%22Takayanagi%2C+R%22">Takayanagi, R</searchLink><br /><searchLink fieldCode="AR" term="%22Kita%2C+Y%22">Kita, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Ueshima%2C+H%22">Ueshima, H</searchLink><br /><searchLink fieldCode="AR" term="%22Hsiung%2C+CA%22">Hsiung, CA</searchLink><br /><searchLink fieldCode="AR" term="%22Cui%2C+J%22">Cui, J</searchLink><br /><searchLink fieldCode="AR" term="%22Sheu%2C+WHH%22">Sheu, WHH</searchLink><br /><searchLink fieldCode="AR" term="%22Rotter%2C+JI%22">Rotter, JI</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+YDI%22">Chen, YDI</searchLink><br /><searchLink fieldCode="AR" term="%22Hsu%2C+C%22">Hsu, C</searchLink><br /><searchLink fieldCode="AR" term="%22Okada%2C+Y%22">Okada, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Kubo%2C+M%22">Kubo, M</searchLink><br /><searchLink fieldCode="AR" term="%22Takahashi%2C+A%22">Takahashi, A</searchLink><br /><searchLink fieldCode="AR" term="%22Tanaka%2C+T%22">Tanaka, T</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Rooij%2C+FJA%22">Van Rooij, FJA</searchLink><br /><searchLink fieldCode="AR" term="%22Ganesh%2C+SK%22">Ganesh, SK</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+J%22">Huang, J</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+T%22">Huang, T</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+J%22">Yuan, J</searchLink><br /><searchLink fieldCode="AR" term="%22Hwang%2C+JY%22">Hwang, JY</searchLink><br /><searchLink fieldCode="AR" term="%22Gross%2C+MD%22">Gross, MD</searchLink><br /><searchLink fieldCode="AR" term="%22Assimes%2C+TL%22">Assimes, TL</searchLink><br /><searchLink fieldCode="AR" term="%22Miki%2C+T%22">Miki, T</searchLink><br /><searchLink fieldCode="AR" term="%22Shu%2C+XO%22">Shu, XO</searchLink><br /><searchLink fieldCode="AR" term="%22Qi%2C+L%22">Qi, L</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+YT%22">Chen, YT</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+X%22">Lin, X</searchLink><br /><searchLink fieldCode="AR" term="%22Aung%2C+T%22">Aung, T</searchLink><br /><searchLink fieldCode="AR" term="%22Wong%2C+TY%22">Wong, TY</searchLink><br /><searchLink fieldCode="AR" term="%22Teo%2C+YY%22">Teo, YY</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+BJ%22">Kim, BJ</searchLink><br /><searchLink fieldCode="AR" term="%22Kato%2C+N%22">Kato, N</searchLink><br /><searchLink fieldCode="AR" term="%22Tai%2C+ES%22">Tai, ES</searchLink> – Name: Publisher Label: Publisher Information Group: PubInfo Data: American Diabetes Association – Name: DatePubCY Label: Publication Year Group: Date Data: 2014 – Name: Subset Label: Collection Group: HoldingsInfo Data: The University of Melbourne: Digital Repository – Name: Abstract Label: Description Group: Ab Data: Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (<7.0 mmol/L) but elevated HbA1c (≥6.5%), 36.1% had HbA1c <6.5% after adjustment for these six variants. Our East Asian GWAS meta-analysis has identified novel variants associated with HbA1c as well as demonstrated that the effects of known variants are largely transferable across ethnic groups. Variants affecting erythrocyte parameters rather than glucose metabolism may be relevant to the use of HbA1c for diagnosing diabetes in these populations. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 0012-1797 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://hdl.handle.net/11343/306278 – Name: URL Label: Availability Group: URL Data: https://hdl.handle.net/11343/306278 – Name: Copyright Label: Rights Group: Cpyrght Data: https://creativecommons.org/licenses/by-nc-nd/4.0 ; CC BY-NC-ND – Name: AN Label: Accession Number Group: ID Data: edsbas.C24941AB |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.C24941AB |
| RecordInfo | BibRecord: BibEntity: Languages: – Text: English Titles: – TitleFull: Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, P – PersonEntity: Name: NameFull: Takeuchi, F – PersonEntity: Name: NameFull: Lee, JY – PersonEntity: Name: NameFull: Li, H – PersonEntity: Name: NameFull: Wu, JY – PersonEntity: Name: NameFull: Liang, J – PersonEntity: Name: NameFull: Long, J – PersonEntity: Name: NameFull: Tabara, Y – PersonEntity: Name: NameFull: Goodarzi, MO – PersonEntity: Name: NameFull: Pereira, MA – PersonEntity: Name: NameFull: Kim, YJ – PersonEntity: Name: NameFull: Go, MJ – PersonEntity: Name: NameFull: Stram, DO – PersonEntity: Name: NameFull: Vithana, E – PersonEntity: Name: NameFull: Khor, CC – PersonEntity: Name: NameFull: Liu, J – PersonEntity: Name: NameFull: Liao, J – PersonEntity: Name: NameFull: Ye, X – PersonEntity: Name: NameFull: Wang, Y – PersonEntity: Name: NameFull: Lu, L – PersonEntity: Name: NameFull: Young, TL – PersonEntity: Name: NameFull: Lee, J – PersonEntity: Name: NameFull: Thai, AC – PersonEntity: Name: NameFull: Cheng, CY – PersonEntity: Name: NameFull: Van Dam, RM – PersonEntity: Name: NameFull: Friedlander, Y – PersonEntity: Name: NameFull: Heng, CK – PersonEntity: Name: NameFull: Koh, WP – PersonEntity: Name: NameFull: Chen, CH – PersonEntity: Name: NameFull: Chang, LC – PersonEntity: Name: NameFull: Pan, WH – PersonEntity: Name: NameFull: Qi, B – PersonEntity: Name: NameFull: Isono, M – PersonEntity: Name: NameFull: Zheng, W – PersonEntity: Name: NameFull: Cai, Q – PersonEntity: Name: NameFull: Gao, Y – PersonEntity: Name: NameFull: Yamamoto, K – PersonEntity: Name: NameFull: Ohnaka, K – PersonEntity: Name: NameFull: Takayanagi, R – PersonEntity: Name: NameFull: Kita, Y – PersonEntity: Name: NameFull: Ueshima, H – PersonEntity: Name: NameFull: Hsiung, CA – PersonEntity: Name: NameFull: Cui, J – PersonEntity: Name: NameFull: Sheu, WHH – PersonEntity: Name: NameFull: Rotter, JI – PersonEntity: Name: NameFull: Chen, YDI – PersonEntity: Name: NameFull: Hsu, C – PersonEntity: Name: NameFull: Okada, Y – PersonEntity: Name: NameFull: Kubo, M – PersonEntity: Name: NameFull: Takahashi, A – PersonEntity: Name: NameFull: Tanaka, T – PersonEntity: Name: NameFull: Van Rooij, FJA – PersonEntity: Name: NameFull: Ganesh, SK – PersonEntity: Name: NameFull: Huang, J – PersonEntity: Name: NameFull: Huang, T – PersonEntity: Name: NameFull: Yuan, J – PersonEntity: Name: NameFull: Hwang, JY – PersonEntity: Name: NameFull: Gross, MD – PersonEntity: Name: NameFull: Assimes, TL – PersonEntity: Name: NameFull: Miki, T – PersonEntity: Name: NameFull: Shu, XO – PersonEntity: Name: NameFull: Qi, L – PersonEntity: Name: NameFull: Chen, YT – PersonEntity: Name: NameFull: Lin, X – PersonEntity: Name: NameFull: Aung, T – PersonEntity: Name: NameFull: Wong, TY – PersonEntity: Name: NameFull: Teo, YY – PersonEntity: Name: NameFull: Kim, BJ – PersonEntity: Name: NameFull: Kato, N – PersonEntity: Name: NameFull: Tai, ES IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00121797 – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa |
| ResultId | 1 |