Academic Journal
Kidney transplantation in sensitized recipients; a single center experience
| Τίτλος: | Kidney transplantation in sensitized recipients; a single center experience |
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| Συγγραφείς: | Kim, Sun Moon, Lee, Chungsik, Lee, Jung Pyo, Kim, Eun Man, Ha, Jongwon, Kim, Sang Joon, Park, Myoung Hee, Ahn, Curie, Kim, Yon Su |
| Συνεισφορές: | 김선문, 이정식, 이정표, 김은만, 하종원, 김상준, 박명희, 안규리, 김연수 |
| Στοιχεία εκδότη: | Korean Academy of Medical Science |
| Έτος έκδοσης: | 2009 |
| Συλλογή: | Seoul National University: S-Space |
| Θεματικοί όροι: | Adult, Antibodies, Monoclonal/pharmacology, Antigens, CD20/biosynthesis, Biopsy, Female, Graft Rejection, Graft Survival, Histocompatibility Testing/methods, Humans, Immunoglobulins/chemistry, Kidney Transplantation/*methods, Male, Middle Aged, Plasmapheresis, Transplantation Conditioning |
| Περιγραφή: | A successful transplantation, across a positive crossmatch barrier, is one of the most persistent long-standing problems in the field of kidney transplant medicine. The aim of this study was to describe seven consecutive living renal transplantations in recipients with positive crossmatch for donors or positive for donor specific antibodies (DSAs). A preconditioning regimen including plasmapheresis and intravenous immunoglobulin was delivered three times a week until the crossmatch and/or DSAs became negative. Mycophenolate mofetil and tacrolimus were started two days before the plasmapheresis. The protocol was modified to include administration of anti-CD 20 antibody (rituximab, 375 mg/m(2)) from the patient number 3 through the patient number 7. All seven patients achieved negative conversion of the crossmatch or DSAs, and the kidney transplantations were successfully performed in all cases. Acute cellular rejection occurred in two patients, which were subclinical and controlled with high dose steroid treatment. Antibody-mediated rejection occurred in one patient, which was easily reversed with plasmapheresis. All recipients attained normal graft function during the 7-24 months of follow up. Our study suggests that sensitized patients can be transplanted successfully with desensitization pretreatment. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19194544; https://hdl.handle.net/10371/46136 |
| DOI: | 10.3346/jkms.2009.24.S1.S143 |
| Διαθεσιμότητα: | https://hdl.handle.net/10371/46136 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19194544 http://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-24-S143.pdf https://doi.org/10.3346/jkms.2009.24.S1.S143 |
| Αριθμός Καταχώρησης: | edsbas.C1A2849D |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.3346/jkms.2009.24.S1.S143 |
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