Academic Journal
Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor
| Τίτλος: | Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor |
|---|---|
| Συγγραφείς: | Jacques S, Gaikwad H, Pillatzke J, Moghimi SM, Simberg D |
| Πηγή: | Chemical Communications, 2026 |
| Στοιχεία εκδότη: | Royal Society of Chemistry |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Newcastle University Library ePrints Service |
| Περιγραφή: | This journal is © The Royal Society of Chemistry, 2026. Complement opsonisation contributes to immune clearance of nanopharmaceuticals, but complement activation has some undesirable effects. Herein, we show that tethering the fusion complement receptor 2-complement receptor 1 (CR2-CR1) regulator to cross-linked iron oxide nanoworms via a PEG spacer and copper-free click chemistry overcomes complement opsonisation. Furthermore, CR2-CR1-conjugated nanoworms reduce complement opsonisation of unmodified nanoparticles. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | unknown |
| Relation: | https://eprints.ncl.ac.uk/312485; https://eprints.ncl.ac.uk/fulltext.aspx?url=312485/E2E6BE16-7D15-44AD-A9BA-56F192D37100.pdf&pub_id=312485 |
| Διαθεσιμότητα: | https://eprints.ncl.ac.uk/312485 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.BAF50AA0 |
| Βάση Δεδομένων: | BASE |
καταχωρήστε σχόλιο πρώτοι!