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Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections

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Τίτλος: Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections
Συγγραφείς: Casals, Eudald, Gusta, Muriel F., Bastús, Neus G., Rello, Jordi, Puntes, Víctor F.
Συνεισφορές: Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya, Casals, Eudald, Gusta, Muriel F., Bastús, Neus G., Rello, Jordi, Consejo Superior de Investigaciones Científicas https://ror.org/02gfc7t72
Στοιχεία εκδότη: Multidisciplinary Digital Publishing Institute
Έτος έκδοσης: 2025
Συλλογή: Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council)
Θεματικοί όροι: Antibiotic resistance, Silver nanoparticles, Multidrug-resistant pathogens, Antimicrobial synergy, Controlled ion release
Περιγραφή: The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and funding programs in the 2000s, silver ions have re-emerged as potent antimicrobial agents, offering a promising complement to conventional therapies. This therapeutic potential is nowadays explored through the use of silver nanoparticles (AgNPs) as sources for silver ions release. Recent studies have shown that controlled silver ion release enhances the efficacy of common antibiotics. This can be attributed to the energetically demanding nature of the bacterial response to silver, which weakens bacterial metabolism and, in turn, overwhelms bacterial defenses and increases antibiotic effectiveness. Herein, historical insights into the use of colloidal silver and AgNPs are combined with a review of recent research on the exploitation of the synergistic effect between AgNPs and antibiotics as a promising strategy against MDR pathogens. ; This research was funded by the international joint research projects program MCIN/AEI (CONCORD, PCI2019-103436), co-funded by the European Union and Generalitat de Catalunya (2021-SGR-00878). ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI (Grant No.: CEX2021-001214-S) and receives funding from the CERCA Programme/Generalitat de Catalunya. ; With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001214-S) ; Peer reviewed
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCI2019-103436/ES/NANOPARTICULAS CATIONICAS DE ORO MEDIADAS POR ARNM CITOPLASMATICO DIRIGIDO A LA PRODUCCION DE LINFOCITOS CAR-T PARA LA INMUNOTERAPIA DE LEUCEMIA LINFOIDE CRONICA (CONCORD)/; info:eu-repo/grantAgreement/AEI//CEX2021-001214-S; https://doi.org/10.3390/microorganisms13040952; Sí; Microorganisms 13(4): 952 (2025); https://hdl.handle.net/10261/391260; http://dx.doi.org/10.13039/501100002809; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004837
DOI: 10.3390/microorganisms13040952
DOI: 10.13039/501100002809
DOI: 10.13039/501100011033
DOI: 10.13039/501100000780
DOI: 10.13039/501100004837
Διαθεσιμότητα: https://hdl.handle.net/10261/391260
https://doi.org/10.3390/microorganisms13040952
https://doi.org/10.13039/501100002809
https://doi.org/10.13039/501100011033
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/501100004837
Rights: info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης: edsbas.B59EB88C
Βάση Δεδομένων: BASE
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  Availability: 0
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  Data: Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections
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  Data: <searchLink fieldCode="AR" term="%22Casals%2C+Eudald%22">Casals, Eudald</searchLink><br /><searchLink fieldCode="AR" term="%22Gusta%2C+Muriel+F%2E%22">Gusta, Muriel F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bastús%2C+Neus+G%2E%22">Bastús, Neus G.</searchLink><br /><searchLink fieldCode="AR" term="%22Rello%2C+Jordi%22">Rello, Jordi</searchLink><br /><searchLink fieldCode="AR" term="%22Puntes%2C+Víctor+F%2E%22">Puntes, Víctor F.</searchLink>
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  Data: Ministerio de Ciencia e Innovación (España)<br />Agencia Estatal de Investigación (España)<br />European Commission<br />Generalitat de Catalunya<br />Casals, Eudald<br />Gusta, Muriel F.<br />Bastús, Neus G.<br />Rello, Jordi<br />Consejo Superior de Investigaciones Científicas https://ror.org/02gfc7t72
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  Data: Multidisciplinary Digital Publishing Institute
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22Antibiotic+resistance%22">Antibiotic resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Silver+nanoparticles%22">Silver nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Multidrug-resistant+pathogens%22">Multidrug-resistant pathogens</searchLink><br /><searchLink fieldCode="DE" term="%22Antimicrobial+synergy%22">Antimicrobial synergy</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+ion+release%22">Controlled ion release</searchLink>
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  Data: The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and funding programs in the 2000s, silver ions have re-emerged as potent antimicrobial agents, offering a promising complement to conventional therapies. This therapeutic potential is nowadays explored through the use of silver nanoparticles (AgNPs) as sources for silver ions release. Recent studies have shown that controlled silver ion release enhances the efficacy of common antibiotics. This can be attributed to the energetically demanding nature of the bacterial response to silver, which weakens bacterial metabolism and, in turn, overwhelms bacterial defenses and increases antibiotic effectiveness. Herein, historical insights into the use of colloidal silver and AgNPs are combined with a review of recent research on the exploitation of the synergistic effect between AgNPs and antibiotics as a promising strategy against MDR pathogens. ; This research was funded by the international joint research projects program MCIN/AEI (CONCORD, PCI2019-103436), co-funded by the European Union and Generalitat de Catalunya (2021-SGR-00878). ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI (Grant No.: CEX2021-001214-S) and receives funding from the CERCA Programme/Generalitat de Catalunya. ; With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001214-S) ; Peer reviewed
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