Academic Journal
Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections
| Τίτλος: | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
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| Συγγραφείς: | Casals, Eudald, Gusta, Muriel F., Bastús, Neus G., Rello, Jordi, Puntes, Víctor F. |
| Συνεισφορές: | Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya, Casals, Eudald, Gusta, Muriel F., Bastús, Neus G., Rello, Jordi, Consejo Superior de Investigaciones Científicas https://ror.org/02gfc7t72 |
| Στοιχεία εκδότη: | Multidisciplinary Digital Publishing Institute |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| Θεματικοί όροι: | Antibiotic resistance, Silver nanoparticles, Multidrug-resistant pathogens, Antimicrobial synergy, Controlled ion release |
| Περιγραφή: | The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and funding programs in the 2000s, silver ions have re-emerged as potent antimicrobial agents, offering a promising complement to conventional therapies. This therapeutic potential is nowadays explored through the use of silver nanoparticles (AgNPs) as sources for silver ions release. Recent studies have shown that controlled silver ion release enhances the efficacy of common antibiotics. This can be attributed to the energetically demanding nature of the bacterial response to silver, which weakens bacterial metabolism and, in turn, overwhelms bacterial defenses and increases antibiotic effectiveness. Herein, historical insights into the use of colloidal silver and AgNPs are combined with a review of recent research on the exploitation of the synergistic effect between AgNPs and antibiotics as a promising strategy against MDR pathogens. ; This research was funded by the international joint research projects program MCIN/AEI (CONCORD, PCI2019-103436), co-funded by the European Union and Generalitat de Catalunya (2021-SGR-00878). ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI (Grant No.: CEX2021-001214-S) and receives funding from the CERCA Programme/Generalitat de Catalunya. ; With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001214-S) ; Peer reviewed |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCI2019-103436/ES/NANOPARTICULAS CATIONICAS DE ORO MEDIADAS POR ARNM CITOPLASMATICO DIRIGIDO A LA PRODUCCION DE LINFOCITOS CAR-T PARA LA INMUNOTERAPIA DE LEUCEMIA LINFOIDE CRONICA (CONCORD)/; info:eu-repo/grantAgreement/AEI//CEX2021-001214-S; https://doi.org/10.3390/microorganisms13040952; Sí; Microorganisms 13(4): 952 (2025); https://hdl.handle.net/10261/391260; http://dx.doi.org/10.13039/501100002809; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004837 |
| DOI: | 10.3390/microorganisms13040952 |
| DOI: | 10.13039/501100002809 |
| DOI: | 10.13039/501100011033 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004837 |
| Διαθεσιμότητα: | https://hdl.handle.net/10261/391260 https://doi.org/10.3390/microorganisms13040952 https://doi.org/10.13039/501100002809 https://doi.org/10.13039/501100011033 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004837 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.B59EB88C |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.3390/microorganisms13040952 |
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