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Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex

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Τίτλος: Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex
Συγγραφείς: Bridge, Holly, Bell, Andrew H, Ainsworth, Matthew, Sallet, Jerome, Premereur, Elsie, Ahmed, Bashir, Mitchell, Anna S, Schüffelgen, Urs, Buckley, Mark, Tendler, Benjamin C, Miller, Karla L, Mars, Rogier B, Parker, Andrew J, Krug, Kristine
Πηγή: Bridge, H, Bell, A H, Ainsworth, M, Sallet, J, Premereur, E, Ahmed, B, Mitchell, A S, Schüffelgen, U, Buckley, M, Tendler, B C, Miller, K L, Mars, R B, Parker, A J & Krug, K 2019, 'Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex', eLife, vol. 8. https://doi.org/10.7554/eLife.42325
Έτος έκδοσης: 2019
Συλλογή: King's College, London: Research Portal
Θεματικοί όροι: Animals, Behavior, Animal, Blindness, Cortical/veterinary, Macaca mulatta, Monkey Diseases/congenital, Visual Cortex/pathology, Visual Pathways/physiology, Visual Perception
Περιγραφή: Lesions of primary visual cortex (V1) lead to loss of conscious visual perception with significant impact on human patients. Understanding the neural consequences of such damage may aid the development of rehabilitation methods. In this rare case of a Rhesus macaque (monkey S), likely born without V1, the animal's in-group behaviour was unremarkable, but visual task training was impaired. With multi-modal magnetic resonance imaging, visual structures outside of the lesion appeared normal. Visual stimulation under anaesthesia with checkerboards activated lateral geniculate nucleus of monkey S, while full-field moving dots activated pulvinar. Visual cortical activation was sparse but included face patches. Consistently across lesion and control monkeys, functional connectivity analysis revealed an intact network of bilateral dorsal visual areas temporally correlated with V5/MT activation, even without V1. Despite robust subcortical responses to visual stimulation, we found little evidence for strengthened subcortical input to V5/MT supporting residual visual function or blindsight-like phenomena.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/31120417
DOI: 10.7554/eLife.42325
Διαθεσιμότητα: https://kclpure.kcl.ac.uk/portal/en/publications/52e153c1-d6a6-44ab-b3a3-b297daaba254
https://doi.org/10.7554/eLife.42325
Rights: info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης: edsbas.B495ADDB
Βάση Δεδομένων: BASE
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  – Url: https://kclpure.kcl.ac.uk/portal/en/publications/52e153c1-d6a6-44ab-b3a3-b297daaba254#
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  Data: Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex
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  Data: <searchLink fieldCode="AR" term="%22Bridge%2C+Holly%22">Bridge, Holly</searchLink><br /><searchLink fieldCode="AR" term="%22Bell%2C+Andrew+H%22">Bell, Andrew H</searchLink><br /><searchLink fieldCode="AR" term="%22Ainsworth%2C+Matthew%22">Ainsworth, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Sallet%2C+Jerome%22">Sallet, Jerome</searchLink><br /><searchLink fieldCode="AR" term="%22Premereur%2C+Elsie%22">Premereur, Elsie</searchLink><br /><searchLink fieldCode="AR" term="%22Ahmed%2C+Bashir%22">Ahmed, Bashir</searchLink><br /><searchLink fieldCode="AR" term="%22Mitchell%2C+Anna+S%22">Mitchell, Anna S</searchLink><br /><searchLink fieldCode="AR" term="%22Schüffelgen%2C+Urs%22">Schüffelgen, Urs</searchLink><br /><searchLink fieldCode="AR" term="%22Buckley%2C+Mark%22">Buckley, Mark</searchLink><br /><searchLink fieldCode="AR" term="%22Tendler%2C+Benjamin+C%22">Tendler, Benjamin C</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+Karla+L%22">Miller, Karla L</searchLink><br /><searchLink fieldCode="AR" term="%22Mars%2C+Rogier+B%22">Mars, Rogier B</searchLink><br /><searchLink fieldCode="AR" term="%22Parker%2C+Andrew+J%22">Parker, Andrew J</searchLink><br /><searchLink fieldCode="AR" term="%22Krug%2C+Kristine%22">Krug, Kristine</searchLink>
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  Data: Bridge, H, Bell, A H, Ainsworth, M, Sallet, J, Premereur, E, Ahmed, B, Mitchell, A S, Schüffelgen, U, Buckley, M, Tendler, B C, Miller, K L, Mars, R B, Parker, A J & Krug, K 2019, 'Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex', eLife, vol. 8. https://doi.org/10.7554/eLife.42325
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  Data: 2019
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  Data: King's College, London: Research Portal
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  Data: <searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior%22">Behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Animal%22">Animal</searchLink><br /><searchLink fieldCode="DE" term="%22Blindness%22">Blindness</searchLink><br /><searchLink fieldCode="DE" term="%22Cortical%2Fveterinary%22">Cortical/veterinary</searchLink><br /><searchLink fieldCode="DE" term="%22Macaca+mulatta%22">Macaca mulatta</searchLink><br /><searchLink fieldCode="DE" term="%22Monkey+Diseases%2Fcongenital%22">Monkey Diseases/congenital</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+Cortex%2Fpathology%22">Visual Cortex/pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+Pathways%2Fphysiology%22">Visual Pathways/physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+Perception%22">Visual Perception</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Lesions of primary visual cortex (V1) lead to loss of conscious visual perception with significant impact on human patients. Understanding the neural consequences of such damage may aid the development of rehabilitation methods. In this rare case of a Rhesus macaque (monkey S), likely born without V1, the animal's in-group behaviour was unremarkable, but visual task training was impaired. With multi-modal magnetic resonance imaging, visual structures outside of the lesion appeared normal. Visual stimulation under anaesthesia with checkerboards activated lateral geniculate nucleus of monkey S, while full-field moving dots activated pulvinar. Visual cortical activation was sparse but included face patches. Consistently across lesion and control monkeys, functional connectivity analysis revealed an intact network of bilateral dorsal visual areas temporally correlated with V5/MT activation, even without V1. Despite robust subcortical responses to visual stimulation, we found little evidence for strengthened subcortical input to V5/MT supporting residual visual function or blindsight-like phenomena.
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  Data: info:eu-repo/semantics/altIdentifier/pmid/31120417
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  Data: 10.7554/eLife.42325
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  Data: https://kclpure.kcl.ac.uk/portal/en/publications/52e153c1-d6a6-44ab-b3a3-b297daaba254<br />https://doi.org/10.7554/eLife.42325
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      – Text: English
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