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Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

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Title:	Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Authors:	Steinmetz, J.D., Seeher, K.M., Schiess, N., Nichols, E., Cao, B., Servili, C., Cavallera, V., Cousin, E., Hagins, H., Moberg, M.E., Mehlman, M.L., Abate, Y.H., Abbas, J., Abbasi, M.A., Abbasian, M., Abbastabar, H., Abdelmasseh, M., Abdollahi, M., Abdollahifar, M.-A., Abd-Rabu, R., Abdulah, D.M., Abdullahi, A., Abedi, A., Abedi, V., Abeldańo Zuńiga, R.A., Abidi, H., Abiodun, O., Aboagye, R.G., Abolhassani, H., Aboyans, V., Abrha, W.A., Abualhasan, A., Abu-Gharbieh, E., Aburuz, S., Adamu, L.H., Addo, I.Y., Adebayo, O.M., Adekanmbi, V., Adekiya, T.A., Adikusuma, W., Adnani, Q.E.S., Adra, S., Afework, T., Afolabi, A.A., Afraz, A., Afzal, S., Aghamiri, S., Agodi, A., Agyemang-Duah, W., Ahinkorah, B.O., Ahmad, A., Ahmad, D., Ahmad, S., Ahmadzade, A.M., Ahmed, A., Ahmed, H., Ahmed, J.Q., Ahmed, L.A., Ahmed, M.B., Ahmed, S.A., Ajami, M., Aji, B., Ajumobi, O., Akade, S.E., Akbari, M., Akbarialiabad, H., Akhlaghi, S., Akinosoglou, K., Akinyemi, R.O., Akonde, M., Al Hasan, S.M., Alahdab, F., AL-Ahdal, T.M.A., Al-amer, R.M., Albashtawy, M., AlBataineh, M.T., Aldawsari, K.A., Alemi, H., Alemi, S., Algammal, A.M., Al-Gheethi, A.A.S., Alhalaiqa, F.A.N., Alhassan, R.K., Ali, A., Ali, E.A., Ali, L., Ali, M.U., Ali, M.M., Ali, R., Ali, S., Ali, S.S.S., Ali, Z., Alif, S.M., Alimohamadi, Y., Aliyi, A.A., Aljofan, M., Aljunid, S.M., Alladi, S., Almazan, J.U., Almustanyir, S., Al-Omari, B., Alqahtani, J.S., Alqasmi, I., Alqutaibi, A.Y., Al-Shahi Salman, R., Altaany, Z., Al-Tawfiq, J.A., Altirkawi, K.A., Alvis-Guzman, N., Al-Worafi, Y.M., Aly, H., Aly, S., Alzoubi, K.H., Amani, R., Amindarolzarbi, A., Amiri, S., Amirzade-Iranaq, M.H., Amu, H., Amugsi, D.A., Amusa, G.A., Amzat, J., Ancuceanu, R., Anderlini, D., Anderson, D.B., Andrei, C.L., Androudi, S., Angappan, D., Angesom, T.W., Anil, A., Ansari-Moghaddam, A., Anwer, R., Arafat, M., Aravkin, A.Y., Areda, D., Ariffin, H., Arifin, H., Arkew, M., Ärnlöv, J., Arooj, M., Artamonov, A.A., Artanti, K.D., Aruleba, R.T., Asadi-Pooya, A.A., Asena, T.F., Asghari-Jafarabadi, M., Ashraf, M., Ashraf, T., Atalell, K.A., Athari, S.S., Atinafu, B.T.T., Atorkey, P., Atout, M.M.W., Atreya, A., Aujayeb, A., Avan, A., Ayala Quintanilla, B.P., Ayatollahi, H., Ayinde, O.O., Ayyoubzadeh, S.M., Azadnajafabad, S., Azizi, Z., Azizian, K., Azzam, A.Y., Babaei, M., Badar, M., Badiye, A.D., Baghdadi, S., Bagherieh, S., Bai, R., Baig, A.A., Balakrishnan, S., Balalla, S., Baltatu, O.C., Banach, M., Bandyopadhyay, S., Banerjee, I., Baran, M.F., Barboza, M.A., Barchitta, M., Bardhan, M., Barker-Collo, S.L., Bärnighausen, T.W., Barrow, A., Bashash, D., Bashiri, H., Bashiru, H.A., Basiru, A., Basso, J.D., Basu, S., Batiha, A.-M.M., Batra, K., Baune, B.T., Bedi, N., Begde, A., Begum, T., Behnam, B., Behnoush, A.H., Beiranvand, M., Béjot, Y., Bekele, A., Belete, M.A., Belgaumi, U.I., Bemanalizadeh, M., Bender, R.G., Benfor, B., Bennett, D.A., Bensenor, I.M., Berice, B., Bettencourt, P.J.G., Beyene, K.A., Bhadra, A., Bhagat, D.S., Bhangdia, K., Bhardwaj, N., Bhardwaj, P., Bhargava, A., Bhaskar, S., Bhat, A.N., Bhat, V., Bhatti, G.K., Bhatti, J.S., Bhatti, R., Bijani, A., Bikbov, B., Bilalaga, M.M., Biswas, A., Bitaraf, S., Bitra, V.R., Bjørge, T., Bodolica, V., Bodunrin, A.O., Boloor, A., Braithwaite, D., Brayne, C., Brenner, H., Briko, A., Bringas Vega, M.L., Brown, J., Budke, C.M., Buonsenso, D., Burkart, K., Burns, R.A., Bustanji, Y., Butt, M.H., Butt, N.S., Butt, Z.A., Cabral, L.S., Caetano dos Santos, F.L., Calina, D., Campos-Nonato, I.R., Cao, C., Carabin, H., Cárdenas, R., Carreras, G., Carvalho, A.F., Castańeda-Orjuela, C.A., Casulli, A., Catalá-López, F., Catapano, A.L., Caye, A., Cegolon, L., Cenderadewi, M., Cerin, E., Chacón-Uscamaita, P.R., Chan, J.S.K., Chanie, G.S., Charan, J., Chattu, V.K., Chekol Abebe, E., Chen, H., Chen, J., Chi, G., Chichagi, F., Chidambaram, S.B., Chimoriya, R., Ching, P.R., Chitheer, A., Chong, Y.Y., Chopra, H., Choudhari, S.G., Chowdhury, E.K., Chowdhury, R., Christensen, H., Chu, D.-T., Chukwu, I.S., Chung, E., Coberly, K., Columbus, A., Comachio, J., Conde, J., Cortesi, P.A., Costa, V.M., Couto, R.A.S., Criqui, M.H., Cruz-Martins, N., Dabbagh Ohadi, M.A., Dadana, S., Dadras, O., Dai, X., Dai, Z., D'Amico, E., Danawi, H.A., Dandona, L., Dandona, R., Darwish, A.H., Das, S., Dascalu, A.M., Dash, N.R., Dashti, M., De la Hoz, F.P., de la Torre-Luque, A., De Leo, D., Dean, F.E., Dehghan, A., Dejene, H., Demant, D., Demetriades, A.K., Demissie, S., Deng, X., Desai, H.D., Devanbu, V.G.C., Dhama, K., Dharmaratne, S.D., Dhimal, M., Dias da Silva, D., Diaz, D., Dibas, M., Ding, D.D., Dinu, M., Dirac, M.A., Diress, M., Do, T.C., Do, T.H.P., Doan, K.D.K., Dodangeh, M., Doheim, M.F., Dokova, K.G., Dongarwar, D., Dsouza, H.L., Dube, J., Duraisamy, S., Durojaiye, O.C., Dutta, S., Dziedzic, A.M., Edinur, H.A., Eissazade, N., Ekholuenetale, M., Ekundayo, T.C., El Nahas, N., El Sayed, I., Elahi Najafi, M.A., Elbarazi, I., Elemam, N.M., Elgar, F.J., Elgendy, I.Y., Elhabashy, H.R., Elhadi, M., Elilo, L.T., Ellenbogen, R.G., Elmeligy, O.A.A., Elmonem, M.A., Elshaer, M., Elsohaby, I., Emamverdi, M., Emeto, T.I., Endres, M., Esezobor, C.I., Eskandarieh, S., Fadaei, A., Fagbamigbe, A.F., Fahim, A., Faramarzi, A., Fares, J., Farjoud Kouhanjani, M., Faro, A., Farzadfar, F., Fatehizadeh, A., Fathi, M., Fathi, S., Fatima, S.A.F., Feizkhah, A., Fereshtehnejad, S.-M., Ferrari, A.J., Ferreira, N., Fetensa, G., Firouraghi, N., Fischer, F., Fonseca, A.C., Force, L.M., Fornari, A., Foroutan, B., Fukumoto, T., Gadanya, M.A., Gaidhane, A.M., Galali, Y., Galehdar, N., Gan, Q., Gandhi, A.P., Ganesan, B., Gardner, W.M., Garg, N., Gau, S.-Y., Gautam, R.K., Gebre, T., Gebrehiwot, M., Gebremeskel, G.G., Gebreslassie, H.G., Getacher, L., Ghaderi Yazdi, B., Ghadirian, F., Ghaffarpasand, F., Ghanbari, R., Ghasemi, M., Ghazy, R.M., Ghimire, S., Gholami, A., Gholamrezanezhad, A., Ghotbi, E., Ghozy, S., Gialluisi, A., Gill, P.S., Glasstetter, L.M., Gnedovskaya, E.V., Golchin, A., Golechha, M., Goleij, P., Golinelli, D., Gomes-Neto, M., Goulart, A.C., Goyal, A., Gray, R.J., Grivna, M., Guadie, H.A., Guan, B., Guarducci, G., Guicciardi, S., Gunawardane, D.A., Guo, H., Gupta, B., Gupta, R., Gupta, S., Gupta, V.B., Gupta, V.K., Gutiérrez, R.A., Habibzadeh, F., Hachinski, V., Haddadi, R., Hadei, M., Hadi, N.R., Haep, N., Haile, T.G., Haj-Mirzaian, A., Hall, B.J., Halwani, R., Hameed, S., Hamiduzzaman, M., Hammoud, A., Han, H., Hanifi, N., Hankey, G.J., Hannan, M.A., Hao, J., Harapan, H., Hareru, H.E., Hargono, A., Harlianto, N.I., Haro, J.M., Hartman, N.N., Hasaballah, A.I., Hasan, F., Hasani, H., Hasanian, M., Hassan, A., Hassan, S., Hassanipour, S., Hassankhani, H., Hassen, M.B., Haubold, J., Hay, S.I., Hayat, K., Hegazy, M.I., Heidari, G., Heidari, M., Heidari-Soureshjani, R., Hesami, H., Hezam, K., Hiraike, Y., Hoffman, H.J., Holla, R., Hopf, K.P., Horita, N., Hossain, M.M., Hossain, M.B., Hossain, S., Hosseinzadeh, H., Hosseinzadeh, M., Hostiuc, S., Hu, C., Huang, J., Huda, M.N., Hussain, J., Hussein, N.R., Huynh, H.-H., Hwang, B.-F., Ibitoye, S.E., Ilaghi, M., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Immurana, M., Iravanpour, F., Islam, S.M.S., Ismail, F., Iso, H., Isola, G., Iwagami, M., Iwu, C.C.D., Iyer, M., Jaan, A., Jacob, L., Jadidi-Niaragh, F., Jafari, M., Jafarinia, M., Jafarzadeh, A., Jahankhani, K., Jahanmehr, N., Jahrami, H., Jaiswal, A., Jakovljevic, M., Jamora, R.D.G., Jana, S., Javadi, N., Javed, S., Javeed, S., Jayapal, S.K., Jayaram, S., Jiang, H., Johnson, C.O., Johnson, W.D., Jokar, M., Jonas, J.B., Joseph, A., Joseph, N., Joshua, C.E., Jürisson, M., Kabir, A., Kabir, Z., Kabito, G.G., Kadashetti, V., Kafi, F., Kalani, R., Kalantar, F., Kaliyadan, F., Kamath, A., Kamath, S., Kanchan, T., Kandel, A., Kandel, H., Kanmodi, K.K., Karajizadeh, M., Karami, J., Karanth, S.D., Karaye, I.M., Karch, A., Karimi, A., Karimi, H., Karimi Behnagh, A., Kasraei, H., Kassebaum, N.J., Kauppila, J.H., Kaur, H., Kaur, N., Kayode, G.A., Kazemi, F., Keikavoosi-Arani, L., Keller, C., Keykhaei, M., Khadembashiri, M.A., Khader, Y.S., Khafaie, M.A., Khajuria, H., Khalaji, A., Khamesipour, F., Khammarnia, M., Khan, M., Khan, M.A.B., Khan, Y.H., Khan Suheb, M.Z., Khanmohammadi, S., Khanna, T., Khatab, K., Khatatbeh, H., Khatatbeh, M.M., Khateri, S., Khatib, M.N., Khayat Kashani, H.R., Khonji, M.S., khorashadizadeh, F., Khormali, M., Khubchandani, J., Kian, S., Kim, G., Kim, J., Kim, M.S., Kim, Y.J., Kimokoti, R.W., Kisa, A., Kisa, S., Kivimäki, M., Kochhar, S., Kolahi, A.-A., Koly, K.N., Kompani, F., Koroshetz, W.J., Kosen, S., Kourosh Arami, M., Koyanagi, A., Kravchenko, M.A., Krishan, K., Krishnamoorthy, V., Kuate Defo, B., Kuddus, M.A., Kumar, A., Kumar, G.A., Kumar, M., Kumar, N., Kumsa, N.B., Kundu, S., Kurniasari, M.D., Kusuma, D., Kuttikkattu, A., Kyu, H.H., La Vecchia, C., Ladan, M.A., Lahariya, C., Laksono, T., Lal, D.K., Lallukka, T., Lám, J., Lami, F.H., Landires, I., Langguth, B., Lasrado, S., Latief, K., Latifinaibin, K., Lau, K.M.-M., Laurens, M.B., Lawal, B.K., Le, L.K.D., Le, T.T.T., Ledda, C., Lee, M., Lee, S.-W., Lee, S.W., Lee, W.-C., Lee, Y.H., Leonardi, M., Lerango, T.L., Li, M.-C., Li, W., Ligade, V.S., Lim, S.S., Linehan, C., Liu, C., Liu, J., Liu, W., Lo, C.-H., Lo, W.D., Lobo, S.W., Logroscino, G., Lopes, G., Lopukhov, P.D., Lorenzovici, L., Lorkowski, S., Loureiro, J.A., Lubinda, J., Lucchetti, G., Lutzky Saute, R., Ma, Z.F., Mabrok, M., Machoy, M., Madadizadeh, F., Magdy Abd El Razek, M., Maghazachi, A.A., Maghbouli, N., Mahjoub, S., Mahmoudi, M., Majeed, A., Malagón-Rojas, J.N., Malakan Rad, E., Malhotra, K., Malik, A.A., Malik, I., Mallhi, T.H., Malta, D.C., Manilal, A., Mansouri, V., Mansournia, M.A., Marasini, B.P., Marateb, H.R., Maroufi, S.F., Martinez-Raga, J., Martini, S., Martins-Melo, F.R., Martorell, M., März, W., Marzo, R.R., Massano, J., Mathangasinghe, Y., Mathews, E., Maude, R.J., Maugeri, A., Maulik, P.K., Mayeli, M., Mazaheri, M., McAlinden, C., McGrath, J.J., Meena, J.K., Mehndiratta, M.M., Mendez-Lopez, M.A.M., Mendoza, W., Mendoza-Cano, O., Menezes, R.G., Merati, M., Meretoja, A., Merkin, A., Mersha, A.M., Mestrovic, T., Mi, T., Miazgowski, T., Michalek, I.M., Mihretie, E.T., Minh, L.H.N., Mirfakhraie, R., Mirica, A., Mirrakhimov, E.M., Mirzaei, M., Misganaw, A., Misra, S., Mithra, P., Mizana, B.A., Mohamadkhani, A., Mohamed, N.S., Mohammadi, E., Mohammadi, H., Mohammadi, S., Mohammadshahi, M., Mohammed, M., Mohammed, S., Mohan, S., Mojiri-forushani, H., Moka, N., Mokdad, A.H., Molinaro, S., Möller, H., Monasta, L., Moniruzzaman, M., Montazeri, F., Moradi, M., Moradi, Y., Moradi-Lakeh, M., Moraga, P., Morovatdar, N., Morrison, S.D., Mosapour, A., Mosser, J.F., Mossialos, E., Motaghinejad, M., Mousavi, P., Mousavi, S.E., Mubarik, S., Muccioli, L., Mughal, F., Mukoro, G.D., Mulita, A., Mulita, F., Musaigwa, F., Mustafa, A., Mustafa, G., Muthu, S., Nagarajan, A.J., Naghavi, P., Naik, G.R., Nainu, F., Nair, T.S., Najmuldeen, H.H.R., Nakhostin Ansari, N., Nambi, G., Namdar Areshtanab, H., Nargus, S., Nascimento, B.R., Naser, A.Y., Nashwan, A.J.J., Nasoori, H., Nasreldein, A., Natto, Z.S., Nauman, J., Nayak, B.P., Nazri-Panjaki, A., Negaresh, M., Negash, H., Negoi, I., Negoi, R.I., Negru, S.M., Nejadghaderi, S.A., Nematollahi, M.H., Nesbit, O.D., Newton, C.R.J., Nguyen, D.H., Nguyen, H.T.H., Nguyen, H.Q., Nguyen, N.-T.T., Nguyen, P.T., Nguyen, V.T., Niazi, R.K., Nikolouzakis, T.K., Niranjan, V., Nnyanzi, L.A., Noman, E.A., Noroozi, N., Norrving, B., Noubiap, J.J., Nri-Ezedi, C.A., Ntaios, G., Nuńez-Samudio, V., Nurrika, D., Oancea, B., Odetokun, I.A., O'Donnell, M.J., Ogunsakin, R.E., Oguta, J.O., Oh, I.-H., Okati-Aliabad, H., Okeke, S.R., Okekunle, A.P., Okonji, O.C., Okwute, P.G., Olagunju, A.T., Olaiya, M.T., Olana, M.D., Olatubi, M.I., Oliveira, G.M.M., Olufadewa, I.I., Olusanya, B.O., Omar Bali, A., Ong, S., Onwujekwe, O.E., Ordak, M., Orji, A.U., Ortega-Altamirano, D.V., Osuagwu, U.L., Otstavnov, N., Otstavnov, S.S., Ouyahia, A., Owolabi, M.O., P A, M.P., Pacheco-Barrios, K., Padubidri, J.R., Pal, P.K., Palange, P.N., Palladino, C., Palladino, R., Palma-Alvarez, R.F., Pan, F., Panagiotakos, D., Panda-Jonas, S., Pandey, A., Pandian, J.D., Pangaribuan, H.U., Pantazopoulos, I., Pardhan, S., Parija, P.P., Parikh, R.R., Park, S., Parthasarathi, A., Pashaei, A., Patel, J., Patil, S., Patoulias, D., Pawar, S., Pedersini, P., Pensato, U., Pereira, D.M., Pereira, J., Pereira, M.O., Peres, M.F.P., Perico, N., Perna, S., Petcu, I.-R., Petermann-Rocha, F.E., Pham, H.T., Phillips, M.R., Pinilla-Monsalve, G.D., Piradov, M.A., Plotnikov, E., Poddighe, D., Polat, B., Poluru, R., Pond, C.D., Poudel, G.R., Pouramini, A., Pourbagher-Shahri, A.M., Pourfridoni, M., Pourtaheri, N., Prakash, P.Y., Prakash, S., Prakash, V., Prates, E.J.S., Pritchett, N., Purnobasuki, H., Qasim, N.H., Qattea, I., Qian, G., Radhakrishnan, V., Raee, P., Raeisi Shahraki, H., Rafique, I., Raggi, A., Raghav, P.R., Rahati, M.M., 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Publisher Information:	Elsevier BV
Publication Year:	2024
Collection:	White Rose Research Online (Universities of Leeds, Sheffield & York)
Description:	Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings: Globally, the 37 ...
Document Type:	article in journal/newspaper
File Description:	text
Language:	English
ISSN:	1474-4422
Relation:	https://eprints.whiterose.ac.uk/id/eprint/216637/1/Global,%20regional,%20and%20national%20burden%20of%20disorders%20affecting%20the%20nervous%20system,%201990-2021%20a%20systematic%20analysis%20for%20the%20Glo.pdf; Steinmetz, J.D., Seeher, K.M., Schiess, N. et al. (1261 more authors) (2024) Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology, 23 (4). pp. 344-381. ISSN: 1474-4422
DOI:	10.1016/s1474-4422(24)00038-3
Availability:	https://eprints.whiterose.ac.uk/id/eprint/216637/ https://doi.org/10.1016/s1474-4422(24)00038-3
Rights:	cc_by_4
Accession Number:	edsbas.B392CFC
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/><searchLink fieldCode="AR" term="%22Zangiabadian%2C+M%2E%22">Zangiabadian, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Zarghami%2C+A%2E%22">Zarghami, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Zastrozhin%2C+M%2ES%2E%22">Zastrozhin, M.S.</searchLink><br /><searchLink fieldCode="AR" term="%22Zeariya%2C+M%2EG%2EM%2E%22">Zeariya, M.G.M.</searchLink><br /><searchLink fieldCode="AR" term="%22Zegeye%2C+Z%2EB%2E%22">Zegeye, Z.B.</searchLink><br /><searchLink fieldCode="AR" term="%22Zeukeng%2C+F%2E%22">Zeukeng, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhai%2C+C%2E%22">Zhai, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+C%2E%22">Zhang, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+H%2E%22">Zhang, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Y%2E%22">Zhang, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Z%2E-J%2E%22">Zhang, Z.-J.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+H%2E%22">Zhao, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Y%2E%22">Zhao, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Zheng%2C+P%2E%22">Zheng, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhou%2C+H%2E%22">Zhou, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+B%2E%22">Zhu, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhumagaliuly%2C+A%2E%22">Zhumagaliuly, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Zielińska%2C+M%2E%22">Zielińska, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Zikarg%2C+Y%2ET%2E%22">Zikarg, Y.T.</searchLink><br /><searchLink fieldCode="AR" term="%22Zoladl%2C+M%2E%22">Zoladl, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Murray%2C+C%2EJ%2EL%2E%22">Murray, C.J.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ong%2C+K%2EL%2E%22">Ong, K.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Feigin%2C+V%2EL%2E%22">Feigin, V.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Vos%2C+T%2E%22">Vos, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Dua%2C+T%2E%22">Dua, T.</searchLink> – Name: Publisher Label: Publisher Information Group: PubInfo Data: Elsevier BV – Name: DatePubCY Label: Publication Year Group: Date Data: 2024 – Name: Subset Label: Collection Group: HoldingsInfo Data: White Rose Research Online (Universities of Leeds, Sheffield & York) – Name: Abstract Label: Description Group: Ab Data: Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings: Globally, the 37 ... – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: text – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1474-4422 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://eprints.whiterose.ac.uk/id/eprint/216637/1/Global,%20regional,%20and%20national%20burden%20of%20disorders%20affecting%20the%20nervous%20system,%201990-2021%20a%20systematic%20analysis%20for%20the%20Glo.pdf; Steinmetz, J.D., Seeher, K.M., Schiess, N. et al. (1261 more authors) (2024) Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology, 23 (4). pp. 344-381. ISSN: 1474-4422 – Name: DOI Label: DOI Group: ID Data: 10.1016/s1474-4422(24)00038-3 – Name: URL Label: Availability Group: URL Data: https://eprints.whiterose.ac.uk/id/eprint/216637/<br />https://doi.org/10.1016/s1474-4422(24)00038-3 – Name: Copyright Label: Rights Group: Cpyrght Data: cc_by_4 – Name: AN Label: Accession Number Group: ID Data: edsbas.B392CFC
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