Academic Journal
Προβολή σε EDS

Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals
Συγγραφείς: Panca M, Blackstone J, Stirrup O, Cutino-Moguel M-T, Thomson E, Peters C, Snell LB, Nebbia G, Holmes A, Chawla A, Machin N, Taha Y, Mahungu T, Saluja T, de Silva TI, Saeed K, Pope C, Shin GY, Williams R, Darby A, Smith DL, Loose M, Robson SC, Laing K, Partridge DG, Price JR, Breuer J
Πηγή: Journal of Hospital Infection, September 2023
Στοιχεία εκδότη: W.B. Saunders Ltd
Έτος έκδοσης: 2023
Συλλογή: Newcastle University Library ePrints Service
Περιγραφή: © 2023 The AuthorsBackground: The COG-UK hospital-onset COVID-19 infection (HOCI) trial evaluated the impact of SARS-CoV-2 whole-genome sequencing (WGS) on acute infection, prevention, and control (IPC) investigation of nosocomial transmission within hospitals. Aim: To estimate the cost implications of using the information from the sequencing reporting tool (SRT), used to determine likelihood of nosocomial infection in IPC practice. Methods: A micro-costing approach for SARS-CoV-2 WGS was conducted. Data on IPC management resource use and costs were collected from interviews with IPC teams from 14 participating sites and used to assign cost estimates for IPC activities as collected in the trial. Activities included IPC-specific actions following a suspicion of healthcare-associated infection (HAI) or outbreak, as well as changes to practice following the return of data via SRT. Findings: The mean per-sample costs of SARS-CoV-2 sequencing were estimated at £77.10 for rapid and £66.94 for longer turnaround phases. Over the three-month interventional phases, the total management costs of IPC-defined HAIs and outbreak events across the sites were estimated at £225,070 and £416,447, respectively. The main cost drivers were bed-days lost due to ward closures because of outbreaks, followed by outbreak meetings and bed-days lost due to cohorting contacts. Actioning SRTs, the cost of HAIs increased by £5,178 due to unidentified cases and the cost of outbreaks decreased by £11,246 as SRTs excluded hospital outbreaks. Conclusion: Although SARS-CoV-2 WGS adds to the total IPC management cost, additional information provided could balance out the additional cost, depending on identified design improvements and effective deployment.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: unknown
Relation: https://eprints.ncl.ac.uk/292383; https://eprints.ncl.ac.uk/fulltext.aspx?url=292383/B4C2563D-2F8A-498E-BC26-A58DFC6C1014.pdf&pub_id=292383
Διαθεσιμότητα: https://eprints.ncl.ac.uk/292383
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.ADF52174
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://eprints.ncl.ac.uk/292383#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.ADF52174
RelevancyScore: 926
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 926.330688476563
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Panca+M%22">Panca M</searchLink><br /><searchLink fieldCode="AR" term="%22Blackstone+J%22">Blackstone J</searchLink><br /><searchLink fieldCode="AR" term="%22Stirrup+O%22">Stirrup O</searchLink><br /><searchLink fieldCode="AR" term="%22Cutino-Moguel+M-T%22">Cutino-Moguel M-T</searchLink><br /><searchLink fieldCode="AR" term="%22Thomson+E%22">Thomson E</searchLink><br /><searchLink fieldCode="AR" term="%22Peters+C%22">Peters C</searchLink><br /><searchLink fieldCode="AR" term="%22Snell+LB%22">Snell LB</searchLink><br /><searchLink fieldCode="AR" term="%22Nebbia+G%22">Nebbia G</searchLink><br /><searchLink fieldCode="AR" term="%22Holmes+A%22">Holmes A</searchLink><br /><searchLink fieldCode="AR" term="%22Chawla+A%22">Chawla A</searchLink><br /><searchLink fieldCode="AR" term="%22Machin+N%22">Machin N</searchLink><br /><searchLink fieldCode="AR" term="%22Taha+Y%22">Taha Y</searchLink><br /><searchLink fieldCode="AR" term="%22Mahungu+T%22">Mahungu T</searchLink><br /><searchLink fieldCode="AR" term="%22Saluja+T%22">Saluja T</searchLink><br /><searchLink fieldCode="AR" term="%22de+Silva+TI%22">de Silva TI</searchLink><br /><searchLink fieldCode="AR" term="%22Saeed+K%22">Saeed K</searchLink><br /><searchLink fieldCode="AR" term="%22Pope+C%22">Pope C</searchLink><br /><searchLink fieldCode="AR" term="%22Shin+GY%22">Shin GY</searchLink><br /><searchLink fieldCode="AR" term="%22Williams+R%22">Williams R</searchLink><br /><searchLink fieldCode="AR" term="%22Darby+A%22">Darby A</searchLink><br /><searchLink fieldCode="AR" term="%22Smith+DL%22">Smith DL</searchLink><br /><searchLink fieldCode="AR" term="%22Loose+M%22">Loose M</searchLink><br /><searchLink fieldCode="AR" term="%22Robson+SC%22">Robson SC</searchLink><br /><searchLink fieldCode="AR" term="%22Laing+K%22">Laing K</searchLink><br /><searchLink fieldCode="AR" term="%22Partridge+DG%22">Partridge DG</searchLink><br /><searchLink fieldCode="AR" term="%22Price+JR%22">Price JR</searchLink><br /><searchLink fieldCode="AR" term="%22Breuer+J%22">Breuer J</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Hospital Infection, September 2023
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: W.B. Saunders Ltd
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Newcastle University Library ePrints Service
– Name: Abstract
  Label: Description
  Group: Ab
  Data: © 2023 The AuthorsBackground: The COG-UK hospital-onset COVID-19 infection (HOCI) trial evaluated the impact of SARS-CoV-2 whole-genome sequencing (WGS) on acute infection, prevention, and control (IPC) investigation of nosocomial transmission within hospitals. Aim: To estimate the cost implications of using the information from the sequencing reporting tool (SRT), used to determine likelihood of nosocomial infection in IPC practice. Methods: A micro-costing approach for SARS-CoV-2 WGS was conducted. Data on IPC management resource use and costs were collected from interviews with IPC teams from 14 participating sites and used to assign cost estimates for IPC activities as collected in the trial. Activities included IPC-specific actions following a suspicion of healthcare-associated infection (HAI) or outbreak, as well as changes to practice following the return of data via SRT. Findings: The mean per-sample costs of SARS-CoV-2 sequencing were estimated at £77.10 for rapid and £66.94 for longer turnaround phases. Over the three-month interventional phases, the total management costs of IPC-defined HAIs and outbreak events across the sites were estimated at £225,070 and £416,447, respectively. The main cost drivers were bed-days lost due to ward closures because of outbreaks, followed by outbreak meetings and bed-days lost due to cohorting contacts. Actioning SRTs, the cost of HAIs increased by £5,178 due to unidentified cases and the cost of outbreaks decreased by £11,246 as SRTs excluded hospital outbreaks. Conclusion: Although SARS-CoV-2 WGS adds to the total IPC management cost, additional information provided could balance out the additional cost, depending on identified design improvements and effective deployment.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: application/pdf
– Name: Language
  Label: Language
  Group: Lang
  Data: unknown
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://eprints.ncl.ac.uk/292383; https://eprints.ncl.ac.uk/fulltext.aspx?url=292383/B4C2563D-2F8A-498E-BC26-A58DFC6C1014.pdf&pub_id=292383
– Name: URL
  Label: Availability
  Group: URL
  Data: https://eprints.ncl.ac.uk/292383
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: https://creativecommons.org/licenses/by/4.0/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.ADF52174
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.ADF52174
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: unknown
    Titles:
      – TitleFull: Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Panca M
      – PersonEntity:
          Name:
            NameFull: Blackstone J
      – PersonEntity:
          Name:
            NameFull: Stirrup O
      – PersonEntity:
          Name:
            NameFull: Cutino-Moguel M-T
      – PersonEntity:
          Name:
            NameFull: Thomson E
      – PersonEntity:
          Name:
            NameFull: Peters C
      – PersonEntity:
          Name:
            NameFull: Snell LB
      – PersonEntity:
          Name:
            NameFull: Nebbia G
      – PersonEntity:
          Name:
            NameFull: Holmes A
      – PersonEntity:
          Name:
            NameFull: Chawla A
      – PersonEntity:
          Name:
            NameFull: Machin N
      – PersonEntity:
          Name:
            NameFull: Taha Y
      – PersonEntity:
          Name:
            NameFull: Mahungu T
      – PersonEntity:
          Name:
            NameFull: Saluja T
      – PersonEntity:
          Name:
            NameFull: de Silva TI
      – PersonEntity:
          Name:
            NameFull: Saeed K
      – PersonEntity:
          Name:
            NameFull: Pope C
      – PersonEntity:
          Name:
            NameFull: Shin GY
      – PersonEntity:
          Name:
            NameFull: Williams R
      – PersonEntity:
          Name:
            NameFull: Darby A
      – PersonEntity:
          Name:
            NameFull: Smith DL
      – PersonEntity:
          Name:
            NameFull: Loose M
      – PersonEntity:
          Name:
            NameFull: Robson SC
      – PersonEntity:
          Name:
            NameFull: Laing K
      – PersonEntity:
          Name:
            NameFull: Partridge DG
      – PersonEntity:
          Name:
            NameFull: Price JR
      – PersonEntity:
          Name:
            NameFull: Breuer J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: Journal of Hospital Infection, September 2023
              Type: main
ResultId 1