Academic Journal
Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane
| Τίτλος: | Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane |
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| Συγγραφείς: | Tousch, Didier, Thomasset, Melodie, Ferrare, Karine, Lajoix, Anne-Dominique, Azay-Milhau, Jacqueline, Poucheret, Patrick |
| Συνεισφορές: | Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM) |
| Πηγή: | ISSN: 1420-3049 ; Molecules ; https://hal.umontpellier.fr/hal-05426087 ; Molecules, 2025, 30 (19), pp.3949. ⟨10.3390/molecules30193949⟩. |
| Στοιχεία εκδότη: | CCSD MDPI |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Université de Montpellier: HAL |
| Θεματικοί όροι: | Health, Chicoric acid, Metabolic syndrome, Endocrine pancreatic insulin secreting cells, Hepatocytes, Hydroxycinnamic acids, Chlorogenic acid, Glucose-6-phosphatase, MESH: Animals, MESH: Caffeic Acids* / chemistry, MESH: Insulin-Secreting Cells* / drug effects, MESH: Insulin-Secreting Cells* / enzymology, MESH: Insulin-Secreting Cells* / metabolism, MESH: Rats, MESH: Caffeic Acids* / pharmacology, MESH: Cell Line, MESH: Chlorogenic Acid* / chemistry, MESH: Chlorogenic Acid* / pharmacology, MESH: Glucose / metabolism, MESH: Glucose / pharmacology, MESH: Glucose-6-Phosphatase* / chemistry, MESH: Glucose-6-Phosphatase* / metabolism, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| Περιγραφή: | International audience ; Chicoric and chlorogenic acids (CRA and CGA), two caffeic acid derivatives found in a large variety of plants, particularly in Asteraceae, are known to modulate glucose-6phosphatase (G6Pase) in hepatic and muscle cells. The aim of the present study is to use CRA/CGA to explore the modulation role and molecular mechanism of endocrine pancreatic beta-cells' insulin secretion. The G6Pase enzyme activity influenced by caffeic and derivatives alone or in combination was assessed on microsomal fractions of INS1-betacells and hepatocytes. Overall, our results show inverse effects of CGA/CRA, allowing us to investigate the G6Pase activity modulation under low and high glucose concentrations. Our data strongly suggests the existence of two putative forms of the G6Pase enzyme. Based on these observations, we formulate the hypothesis of an adaptative bi-conformational model of G6Pase enzyme activity modulation depending on the level of the beta-cell glucose exposure. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.3390/molecules30193949 |
| Διαθεσιμότητα: | https://hal.umontpellier.fr/hal-05426087 https://hal.umontpellier.fr/hal-05426087v1/document https://hal.umontpellier.fr/hal-05426087v1/file/molecules-30-03949.pdf https://doi.org/10.3390/molecules30193949 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Αριθμός Καταχώρησης: | edsbas.AACADB5C |
| Βάση Δεδομένων: | BASE |
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