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Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane

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Title: Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane
Authors: Tousch, Didier, Thomasset, Melodie, Ferrare, Karine, Lajoix, Anne-Dominique, Azay-Milhau, Jacqueline, Poucheret, Patrick
Contributors: Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM)
Source: ISSN: 1420-3049 ; Molecules ; https://hal.umontpellier.fr/hal-05426087 ; Molecules, 2025, 30 (19), pp.3949. ⟨10.3390/molecules30193949⟩.
Publisher Information: CCSD
MDPI
Publication Year: 2025
Collection: Université de Montpellier: HAL
Subject Terms: Health, Chicoric acid, Metabolic syndrome, Endocrine pancreatic insulin secreting cells, Hepatocytes, Hydroxycinnamic acids, Chlorogenic acid, Glucose-6-phosphatase, MESH: Animals, MESH: Caffeic Acids* / chemistry, MESH: Insulin-Secreting Cells* / drug effects, MESH: Insulin-Secreting Cells* / enzymology, MESH: Insulin-Secreting Cells* / metabolism, MESH: Rats, MESH: Caffeic Acids* / pharmacology, MESH: Cell Line, MESH: Chlorogenic Acid* / chemistry, MESH: Chlorogenic Acid* / pharmacology, MESH: Glucose / metabolism, MESH: Glucose / pharmacology, MESH: Glucose-6-Phosphatase* / chemistry, MESH: Glucose-6-Phosphatase* / metabolism, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Description: International audience ; Chicoric and chlorogenic acids (CRA and CGA), two caffeic acid derivatives found in a large variety of plants, particularly in Asteraceae, are known to modulate glucose-6phosphatase (G6Pase) in hepatic and muscle cells. The aim of the present study is to use CRA/CGA to explore the modulation role and molecular mechanism of endocrine pancreatic beta-cells' insulin secretion. The G6Pase enzyme activity influenced by caffeic and derivatives alone or in combination was assessed on microsomal fractions of INS1-betacells and hepatocytes. Overall, our results show inverse effects of CGA/CRA, allowing us to investigate the G6Pase activity modulation under low and high glucose concentrations. Our data strongly suggests the existence of two putative forms of the G6Pase enzyme. Based on these observations, we formulate the hypothesis of an adaptative bi-conformational model of G6Pase enzyme activity modulation depending on the level of the beta-cell glucose exposure.
Document Type: article in journal/newspaper
Language: English
DOI: 10.3390/molecules30193949
Availability: https://hal.umontpellier.fr/hal-05426087
https://hal.umontpellier.fr/hal-05426087v1/document
https://hal.umontpellier.fr/hal-05426087v1/file/molecules-30-03949.pdf
https://doi.org/10.3390/molecules30193949
Rights: http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
Accession Number: edsbas.AACADB5C
Database: BASE
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  Data: Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane
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  Data: <searchLink fieldCode="AR" term="%22Tousch%2C+Didier%22">Tousch, Didier</searchLink><br /><searchLink fieldCode="AR" term="%22Thomasset%2C+Melodie%22">Thomasset, Melodie</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrare%2C+Karine%22">Ferrare, Karine</searchLink><br /><searchLink fieldCode="AR" term="%22Lajoix%2C+Anne-Dominique%22">Lajoix, Anne-Dominique</searchLink><br /><searchLink fieldCode="AR" term="%22Azay-Milhau%2C+Jacqueline%22">Azay-Milhau, Jacqueline</searchLink><br /><searchLink fieldCode="AR" term="%22Poucheret%2C+Patrick%22">Poucheret, Patrick</searchLink>
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  Data: Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud)<br />Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier<br />Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM)<br />Biocommunication en Cardio-Métabolique (BC2M)<br />Université de Montpellier (UM)
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  Data: <i>ISSN: 1420-3049 ; Molecules ; https://hal.umontpellier.fr/hal-05426087 ; Molecules, 2025, 30 (19), pp.3949. ⟨10.3390/molecules30193949⟩</i>.
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  Data: CCSD<br />MDPI
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  Data: 2025
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  Data: Université de Montpellier: HAL
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  Data: <searchLink fieldCode="DE" term="%22Health%22">Health</searchLink><br /><searchLink fieldCode="DE" term="%22Chicoric+acid%22">Chicoric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+syndrome%22">Metabolic syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrine+pancreatic+insulin+secreting+cells%22">Endocrine pancreatic insulin secreting cells</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatocytes%22">Hepatocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxycinnamic+acids%22">Hydroxycinnamic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorogenic+acid%22">Chlorogenic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose-6-phosphatase%22">Glucose-6-phosphatase</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Animals%22">MESH: Animals</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Caffeic+Acids*+%2F+chemistry%22">MESH: Caffeic Acids* / chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Insulin-Secreting+Cells*+%2F+drug+effects%22">MESH: Insulin-Secreting Cells* / drug effects</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Insulin-Secreting+Cells*+%2F+enzymology%22">MESH: Insulin-Secreting Cells* / enzymology</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Insulin-Secreting+Cells*+%2F+metabolism%22">MESH: Insulin-Secreting Cells* / metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Rats%22">MESH: Rats</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Caffeic+Acids*+%2F+pharmacology%22">MESH: Caffeic Acids* / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Cell+Line%22">MESH: Cell Line</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Chlorogenic+Acid*+%2F+chemistry%22">MESH: Chlorogenic Acid* / chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Chlorogenic+Acid*+%2F+pharmacology%22">MESH: Chlorogenic Acid* / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Glucose+%2F+metabolism%22">MESH: Glucose / metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Glucose+%2F+pharmacology%22">MESH: Glucose / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Glucose-6-Phosphatase*+%2F+chemistry%22">MESH: Glucose-6-Phosphatase* / chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Glucose-6-Phosphatase*+%2F+metabolism%22">MESH: Glucose-6-Phosphatase* / metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22[SDV%2ESP]Life+Sciences+[q-bio]%2FPharmaceutical+sciences%22">[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22[SDV%2EBA]Life+Sciences+[q-bio]%2FAnimal+biology%22">[SDV.BA]Life Sciences [q-bio]/Animal biology</searchLink><br /><searchLink fieldCode="DE" term="%22[SDV%2EBBM]Life+Sciences+[q-bio]%2FBiochemistry%22">[SDV.BBM]Life Sciences [q-bio]/Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+Biology%22">Molecular Biology</searchLink>
– Name: Abstract
  Label: Description
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  Data: International audience ; Chicoric and chlorogenic acids (CRA and CGA), two caffeic acid derivatives found in a large variety of plants, particularly in Asteraceae, are known to modulate glucose-6phosphatase (G6Pase) in hepatic and muscle cells. The aim of the present study is to use CRA/CGA to explore the modulation role and molecular mechanism of endocrine pancreatic beta-cells' insulin secretion. The G6Pase enzyme activity influenced by caffeic and derivatives alone or in combination was assessed on microsomal fractions of INS1-betacells and hepatocytes. Overall, our results show inverse effects of CGA/CRA, allowing us to investigate the G6Pase activity modulation under low and high glucose concentrations. Our data strongly suggests the existence of two putative forms of the G6Pase enzyme. Based on these observations, we formulate the hypothesis of an adaptative bi-conformational model of G6Pase enzyme activity modulation depending on the level of the beta-cell glucose exposure.
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– Name: DOI
  Label: DOI
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  Data: 10.3390/molecules30193949
– Name: URL
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  Data: https://hal.umontpellier.fr/hal-05426087<br />https://hal.umontpellier.fr/hal-05426087v1/document<br />https://hal.umontpellier.fr/hal-05426087v1/file/molecules-30-03949.pdf<br />https://doi.org/10.3390/molecules30193949
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  Data: http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
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        Value: 10.3390/molecules30193949
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      – Text: English
    Subjects:
      – SubjectFull: Health
        Type: general
      – SubjectFull: Chicoric acid
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      – SubjectFull: Metabolic syndrome
        Type: general
      – SubjectFull: Endocrine pancreatic insulin secreting cells
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      – SubjectFull: MESH: Chlorogenic Acid* / pharmacology
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        Type: general
      – SubjectFull: MESH: Glucose / pharmacology
        Type: general
      – SubjectFull: MESH: Glucose-6-Phosphatase* / chemistry
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      – SubjectFull: Molecular Biology
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    Titles:
      – TitleFull: Chicoric Acid and Chlorogenic Acid: Two Hydroxycinnamic Acids Modulate the Glucose 6-Phosphatase Activities in Pancreatic INS1 Beta-Cells—Novel Data in Favor of Two Putative Conformations of the G6Pase Within the ER Membrane
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