Academic Journal
Long-term exposure and response to azacitidine for post-hematopoietic stem cell transplantation relapse of early T-cell precursor acute lymphoblastic leukemia: a case report and review of the literature
| Title: | Long-term exposure and response to azacitidine for post-hematopoietic stem cell transplantation relapse of early T-cell precursor acute lymphoblastic leukemia: a case report and review of the literature |
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| Authors: | Jeanselme, Pauline, Tavitian, Suzanne, Lapierre, Léopoldine, Vergez, François, Rigolot, Lucie, Huynh, Anne, Bertoli, Sarah, Delabesse, Eric, Huguet, Françoise |
| Contributors: | Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Hématologie - IUCT-Oncopole CHU Toulouse, Pôle Biologie CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| Source: | ISSN: 1042-8194. |
| Publisher Information: | CCSD Taylor & Francis |
| Publication Year: | 2024 |
| Collection: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: | Azacitidine, early T-cell precursor – acute lymphoblastic leukemia, hypomethylanting agent, long-term treatment, MESH: Adult, MESH: Antimetabolites, Antineoplastic* / therapeutic use, MESH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy, MESH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / therapy, MESH: Recurrence, MESH: Remission Induction / methods, MESH: Transplantation, Homologous, MESH: Treatment Outcome, MESH: Azacitidine* / therapeutic use, MESH: Hematopoietic Stem Cell Transplantation* / adverse effects, MESH: Hematopoietic Stem Cell Transplantation* / methods, MESH: Humans, MESH: Male, MESH: Neoplasm Recurrence, Local / drug therapy, Local / pathology, MESH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: | International audience ; Adult T-cell acute lymphoblastic leukemia has a poor outcome after relapse. Because the subtype of early T-cell precursor displays characteristics close of those of acute myeloid leukemia, such as epigenetic dysregulation, hypomethylating agents might prove of interest. We describe the case of a patient relapsing 3 months only after allogeneic stem cell transplantation who achieved complete remission on azacitidine, and is still on therapy 9 years later. We discuss the biological background of this very long-term response, underlining the immunological effects of hypomethylating agents, and the perspectives opened by combination of hypomethylating agents with other drugs such as venetoclax. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39141583; PUBMED: 39141583 |
| DOI: | 10.1080/10428194.2024.2390572 |
| Availability: | https://hal.science/hal-04783707 https://hal.science/hal-04783707v1/document https://hal.science/hal-04783707v1/file/Jeanselme_2024.pdf https://doi.org/10.1080/10428194.2024.2390572 |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: | edsbas.A73CE45C |
| Database: | BASE |
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