Academic Journal
A comparison of methods to harmonize cortical thickness measurements across scanners and sites
| Τίτλος: | A comparison of methods to harmonize cortical thickness measurements across scanners and sites |
|---|---|
| Συγγραφείς: | Sun, D, Rakesh, G, Haswell, CC, Logue, M, Baird, CL, O'Leary, EN, Cotton, AS, Xie, H, Tamburrino, M, Chen, T, Dennis, EL, Jahanshad, N, Salminen, LE, Thomopoulos, SI, Rashid, F, Ching, CRK, Koch, SBJ, Frijling, JL, Nawijn, L, van Zuiden, M, Zhu, X, Suarez-Jimenez, B, Sierk, A, Walter, H, Manthey, A, Stevens, JS, Fani, N, van Rooij, SJH, Stein, M, Bomyea, J, Koerte, IK, Choi, K, van der Werff, SJA, Vermeiren, RRJM, Herzog, J, Lebois, LAM, Baker, JT, Olson, EA, Straube, T, Korgaonkar, MS, Andrew, E, Zhu, Y, Li, G, Ipser, J, Hudson, AR, Peverill, M, Sambrook, K, Gordon, E, Baugh, L, Forster, G, Simons, RM, Simons, JS, Magnotta, V, Maron-Katz, A, du Plessis, S, Disner, SG, Davenport, N, Grupe, DW, Nitschke, JB, deRoon-Cassini, TA, Fitzgerald, JM, Krystal, JH, Levy, I, Olff, M, Veltman, DJ, Wang, L, Neria, Y, De Bellis, MD, Jovanovic, T, Daniels, JK, Shenton, M, van de Wee, NJA, Schmahl, C, Kaufman, ML, Rosso, IM, Sponheim, SR, Hofmann, DB, Bryant, RA, Fercho, KA, Stein, DJ, Mueller, SC, Hosseini, B, Phan, KL, McLaughlin, KA, Davidson, RJ, Larson, CL, May, G, Nelson, SM, Abdallah, CG, Gomaa, H, Etkin, A, Seedat, S, Harpaz-Rotem, I, Liberzon, I, van Erp, TGM, Quidé, Y, Wang, X, Thompson, PM, Morey, RA, Quide, Yann |
| Πηγή: | urn:ISSN:1053-8119 ; urn:ISSN:1095-9572 ; NeuroImage, 261, 119509 |
| Στοιχεία εκδότη: | Elsevier |
| Έτος έκδοσης: | 2022 |
| Συλλογή: | UNSW Sydney (The University of New South Wales): UNSWorks |
| Θεματικοί όροι: | 32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Brain Disorders, Post-Traumatic Stress Disorder (PTSD), Anxiety Disorders, Mental Health, Biomedical Imaging, 3 Good Health and Well Being, Adolescent, Adult, Aged, 80 and over, Case-Control Studies, Child, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Stress Disorders, Post-Traumatic, Young Adult, ComBat, ComBat-GAM, Cortical Thickness, Data Harmonization, General Additive Model, Linear Mixed-Effects Model, PTSD |
| Περιγραφή: | Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LMEINT), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2–81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3–85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (Χ2(3) = 63.704, p < 0.001) as well as case-control differences in age-related cortical thinning (Χ2(3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (Χ2(3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | unknown |
| Relation: | https://hdl.handle.net/1959.4/unsworks_82147; https://doi.org/10.1016/j.neuroimage.2022.119509 |
| DOI: | 10.1016/j.neuroimage.2022.119509 |
| Διαθεσιμότητα: | https://hdl.handle.net/1959.4/unsworks_82147 https://unsworks.unsw.edu.au/bitstreams/4f7cb115-7313-4eb0-96cf-66aa601873ba/download https://doi.org/10.1016/j.neuroimage.2022.119509 |
| Rights: | open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; free_to_read ; This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.A73BD6C6 |
| Βάση Δεδομένων: | BASE |
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