Dissertation/ Thesis
A New Method for Correcting Gross and Systematic Error in Mass Spectrometry Metabolomics Data
| Title: | A New Method for Correcting Gross and Systematic Error in Mass Spectrometry Metabolomics Data |
|---|---|
| Authors: | Green, Jordan A. |
| Publisher Information: | Yeshiva College |
| Publication Year: | 2016 |
| Collection: | Yeshiva Academic Institutional Repository (YAIR - Yeshiva University) |
| Subject Terms: | Metabolites --Research --Methodology, Mass spectrometry, Metabolism --Research --Methodology, Spectrum analysis --Data processing, Systems biology, Biomolecules |
| Description: | The file is restricted for YU community access only. ; A metabolite is a small molecule produced during or taking part in metabolism, and metabolomics is the study of the unique chemical fingerprints that specific cellular processes leave behind by measuring the presence and intensity of individual metabolites in a biological sample. Metabolomic research has applications in a wide variety of fields, including but not limited to breast cancer research, diabetes treatment, drug development, environmental sciences, and nutrition. To name just one example, individuals with impaired glucose tolerance have been shown to have significantly lower values of the three metabolites glycine, lysophosphatidylcholine (18:2), and acetylcarnitine than those with ordinary glucose tolerance. These metabolites can then be searched for and measured in order to help predict Type 2 diabetes in pre-diabetic individuals with impaired glucose tolerance, meaning that the study of metabolomics may be useful for identifying these patients and possibly preventing them from contracting the disease altogether (Sattler et al. 2012). ; Jay and Jeanie Schottenstein Honors Program |
| Document Type: | thesis |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://hdl.handle.net/20.500.12202/4103; https://ezproxy.yu.edu/login?url=https://repository.yu.edu/handle/20.500.12202/4103 |
| Availability: | https://hdl.handle.net/20.500.12202/4103 https://ezproxy.yu.edu/login?url=https://repository.yu.edu/handle/20.500.12202/4103 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/ |
| Accession Number: | edsbas.A47BB422 |
| Database: | BASE |
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