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Lower Initial Insulin-like Growth Factor-Binding Protein-3 Concentrations May Reflect Immune Suppression and Predict Increased Risk of Sepsis-Related Mortality

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Τίτλος: Lower Initial Insulin-like Growth Factor-Binding Protein-3 Concentrations May Reflect Immune Suppression and Predict Increased Risk of Sepsis-Related Mortality
Συγγραφείς: Mearelli, Filippo, Nunnari, Alessio, Chitti, Federica, Rombini, Annalisa, Macor, Alessandra, Denora, Donatella, Messana, Luca, Scardino, Marianna, Martini, Ilaria, Bolzan, Giulia, Spagnol, Francesca, Casarsa, Chiara, Fiotti, Nicola, Zerbato, Verena, Di Bella, Stefano, Tascini, Carlo, Di Girolamo, Filippo Giorgio, Sturma, Mariella, Costantino, Venera, Biolo, Gianni
Συνεισφορές: Mearelli, Filippo, Nunnari, Alessio, Chitti, Federica, Rombini, Annalisa, Macor, Alessandra, Denora, Donatella, Messana, Luca, Scardino, Marianna, Martini, Ilaria, Bolzan, Giulia, Spagnol, Francesca, Casarsa, Chiara, Fiotti, Nicola, Zerbato, Verena, Di Bella, Stefano, Tascini, Carlo, Di Girolamo, Filippo Giorgio, Sturma, Mariella, Costantino, Venera, Biolo, Gianni
Έτος έκδοσης: 2025
Συλλογή: Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste)
Θεματικοί όροι: procalcitonin, interleukin-6, lactate, mid-regional pro-adrenomedullin, sepsi, immune suppression, gut dysfunction, insulin-like growth factor-binding protein-3, insulin-like growth factor
Περιγραφή: Insulin-like growth factor-binding protein-3 (IGFBP-3) plays a vital role in cellular growth, development, and survival. Incorporating IGFBP-3 into baseline prognostic evaluations may enhance the prediction of mortality in patients with sepsis. In this study, serum levels of IGFBP-3, C-reactive protein, procalcitonin, lactate, interleukin-6, and mid-regional pro-adrenomedullin were measured upon admission to the internal medicine unit (IMU) in 139 patients with microbiologically confirmed sepsis. The objectives were as follows: (1) to classify septic patient phenotypes based on optimal thresholds of independent prognostic biomarkers and (2) to evaluate whether these biomarkers improve the predictive accuracy of a clinical model (Model 1), which includes the clinical predictors of 1-year mortality. Age, sequential organ failure assessment (SOFA) score, multiple sources of infection, and IGFBP-3 levels independently predicted 1-year mortality. Patients with IGFBP-3 levels below 10.64 had significantly lower median body temperature (p = 0.008), reduced lymphocyte count (p = 0.001), and higher 1-year mortality (p < 0.001). Model 1 included age, SOFA score, and the presence of multiple sources of sepsis as predictor variables. Model 2 incorporated the same variables as Model 1, with the addition of IGFBP-3 levels. When comparing their prognostic performance, Model 2 demonstrated superior predictive accuracy for mortality at 60, 90, and 365 days following admission to the IMU. Low IGFBP-3 levels at IMU admission are strongly associated with worse outcomes in septic patients, supporting its potential use as a prognostic biomarker.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: ELETTRONICO
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/40724799; info:eu-repo/semantics/altIdentifier/wos/WOS:001536814000001; volume:26; issue:14; firstpage:"-"; lastpage:"-"; numberofpages:14; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11368/3113259
DOI: 10.3390/ijms26146549
Διαθεσιμότητα: https://hdl.handle.net/11368/3113259
https://doi.org/10.3390/ijms26146549
https://www.mdpi.com/1422-0067/26/14/6549
Rights: info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.9CFE9DFE
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  Data: Lower Initial Insulin-like Growth Factor-Binding Protein-3 Concentrations May Reflect Immune Suppression and Predict Increased Risk of Sepsis-Related Mortality
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  Data: Insulin-like growth factor-binding protein-3 (IGFBP-3) plays a vital role in cellular growth, development, and survival. Incorporating IGFBP-3 into baseline prognostic evaluations may enhance the prediction of mortality in patients with sepsis. In this study, serum levels of IGFBP-3, C-reactive protein, procalcitonin, lactate, interleukin-6, and mid-regional pro-adrenomedullin were measured upon admission to the internal medicine unit (IMU) in 139 patients with microbiologically confirmed sepsis. The objectives were as follows: (1) to classify septic patient phenotypes based on optimal thresholds of independent prognostic biomarkers and (2) to evaluate whether these biomarkers improve the predictive accuracy of a clinical model (Model 1), which includes the clinical predictors of 1-year mortality. Age, sequential organ failure assessment (SOFA) score, multiple sources of infection, and IGFBP-3 levels independently predicted 1-year mortality. Patients with IGFBP-3 levels below 10.64 had significantly lower median body temperature (p = 0.008), reduced lymphocyte count (p = 0.001), and higher 1-year mortality (p &lt; 0.001). Model 1 included age, SOFA score, and the presence of multiple sources of sepsis as predictor variables. Model 2 incorporated the same variables as Model 1, with the addition of IGFBP-3 levels. When comparing their prognostic performance, Model 2 demonstrated superior predictive accuracy for mortality at 60, 90, and 365 days following admission to the IMU. Low IGFBP-3 levels at IMU admission are strongly associated with worse outcomes in septic patients, supporting its potential use as a prognostic biomarker.
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  Data: https://hdl.handle.net/11368/3113259&lt;br /&gt;https://doi.org/10.3390/ijms26146549&lt;br /&gt;https://www.mdpi.com/1422-0067/26/14/6549
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