Academic Journal
Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill
| Τίτλος: | Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill |
|---|---|
| Συγγραφείς: | Dechamps, Mélanie, De Poortere, Julien, Octave, Marie, Ginion, Audrey, Robaux, Valentine, Pirotton, Laurence, Bodart, Julie, Gruson, Damien, Van Dievoet, Marie-Astrid, Douxfils, Jonathan, Haguet, Hélène, Morimont, Laure, Derive, Marc, Jolly, Lucie, Bertrand, Luc, Laterre, Pierre-François, Horman, Sandrine, Beauloye, Christophe |
| Πηγή: | Dechamps, M, De Poortere, J, Octave, M, Ginion, A, Robaux, V, Pirotton, L, Bodart, J, Gruson, D, Van Dievoet, M-A, Douxfils, J, Haguet, H, Morimont, L, Derive, M, Jolly, L, Bertrand, L, Laterre, P-F, Horman, S & Beauloye, C 2023, 'Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill', International Journal of Molecular Sciences, vol. 24, no. 8, 7278. https://doi.org/10.3390/ijms24087278 |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Research Portal - University of Namur / Portail de la recherche de l'Université de Namur |
| Θεματικοί όροι: | Humans, Cytokines, SARS-CoV-2, Critical Illness, COVID-19 Drug Treatment, COVID-19/complications, Dexamethasone/pharmacology, COVID-19, low dose dexamethasone, cytokine storm, inflammation, coagulopathy |
| Περιγραφή: | Severe forms of coronavirus 2019 (COVID-19) disease are caused by an exaggerated systemic inflammatory response and subsequent inflammation-related coagulopathy. Anti-inflammatory treatment with low dose dexamethasone has been shown to reduce mortality in COVID-19 patients requiring oxygen therapy. However, the mechanisms of action of corticosteroids have not been extensively studied in critically ill patients in the context of COVID-19. Plasma biomarkers of inflammatory and immune responses, endothelial and platelet activation, neutrophil extracellular trap formation, and coagulopathy were compared between patients treated or not by systemic dexamethasone for severe forms of COVID-19. Dexamethasone treatment significantly reduced the inflammatory and lymphoid immune response in critical COVID-19 patients but had little effect on the myeloid immune response and no effect on endothelial activation, platelet activation, neutrophil extracellular trap formation, and coagulopathy. The benefits of low dose dexamethasone on outcome in critical COVID-19 can be partially explained by a modulation of the inflammatory response but not by reduction of coagulopathy. Future studies should explore the impact of combining dexamethasone with other immunomodulatory or anticoagulant drugs in severe COVID-19. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1661-6596 1422-0067 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37108440; info:eu-repo/semantics/altIdentifier/pissn/1661-6596; info:eu-repo/semantics/altIdentifier/eissn/1422-0067 |
| DOI: | 10.3390/ijms24087278 |
| Διαθεσιμότητα: | https://researchportal.unamur.be/en/publications/af9342ce-0515-4af6-858c-5e8f13ad1cc6 https://doi.org/10.3390/ijms24087278 https://pure.unamur.be/ws/files/79857347/14959_2023_Dechamps.pdf https://www.scopus.com/pages/publications/85156194201 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.9BC5986B |
| Βάση Δεδομένων: | BASE |
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| Items | – Name: Title Label: Title Group: Ti Data: Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dechamps%2C+Mélanie%22">Dechamps, Mélanie</searchLink><br /><searchLink fieldCode="AR" term="%22De+Poortere%2C+Julien%22">De Poortere, Julien</searchLink><br /><searchLink fieldCode="AR" term="%22Octave%2C+Marie%22">Octave, Marie</searchLink><br /><searchLink fieldCode="AR" term="%22Ginion%2C+Audrey%22">Ginion, Audrey</searchLink><br /><searchLink fieldCode="AR" term="%22Robaux%2C+Valentine%22">Robaux, Valentine</searchLink><br /><searchLink fieldCode="AR" term="%22Pirotton%2C+Laurence%22">Pirotton, Laurence</searchLink><br /><searchLink fieldCode="AR" term="%22Bodart%2C+Julie%22">Bodart, Julie</searchLink><br /><searchLink fieldCode="AR" term="%22Gruson%2C+Damien%22">Gruson, Damien</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Dievoet%2C+Marie-Astrid%22">Van Dievoet, Marie-Astrid</searchLink><br /><searchLink fieldCode="AR" term="%22Douxfils%2C+Jonathan%22">Douxfils, Jonathan</searchLink><br /><searchLink fieldCode="AR" term="%22Haguet%2C+Hélène%22">Haguet, Hélène</searchLink><br /><searchLink fieldCode="AR" term="%22Morimont%2C+Laure%22">Morimont, Laure</searchLink><br /><searchLink fieldCode="AR" term="%22Derive%2C+Marc%22">Derive, Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Jolly%2C+Lucie%22">Jolly, Lucie</searchLink><br /><searchLink fieldCode="AR" term="%22Bertrand%2C+Luc%22">Bertrand, Luc</searchLink><br /><searchLink fieldCode="AR" term="%22Laterre%2C+Pierre-François%22">Laterre, Pierre-François</searchLink><br /><searchLink fieldCode="AR" term="%22Horman%2C+Sandrine%22">Horman, Sandrine</searchLink><br /><searchLink fieldCode="AR" term="%22Beauloye%2C+Christophe%22">Beauloye, Christophe</searchLink> – Name: TitleSource Label: Source Group: Src Data: Dechamps, M, De Poortere, J, Octave, M, Ginion, A, Robaux, V, Pirotton, L, Bodart, J, Gruson, D, Van Dievoet, M-A, Douxfils, J, Haguet, H, Morimont, L, Derive, M, Jolly, L, Bertrand, L, Laterre, P-F, Horman, S & Beauloye, C 2023, 'Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill', International Journal of Molecular Sciences, vol. 24, no. 8, 7278. https://doi.org/10.3390/ijms24087278 – Name: DatePubCY Label: Publication Year Group: Date Data: 2023 – Name: Subset Label: Collection Group: HoldingsInfo Data: Research Portal - University of Namur / Portail de la recherche de l'Université de Namur – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22Critical+Illness%22">Critical Illness</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+Drug+Treatment%22">COVID-19 Drug Treatment</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%2Fcomplications%22">COVID-19/complications</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone%2Fpharmacology%22">Dexamethasone/pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22low+dose+dexamethasone%22">low dose dexamethasone</searchLink><br /><searchLink fieldCode="DE" term="%22cytokine+storm%22">cytokine storm</searchLink><br /><searchLink fieldCode="DE" term="%22inflammation%22">inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22coagulopathy%22">coagulopathy</searchLink> – Name: Abstract Label: Description Group: Ab Data: Severe forms of coronavirus 2019 (COVID-19) disease are caused by an exaggerated systemic inflammatory response and subsequent inflammation-related coagulopathy. Anti-inflammatory treatment with low dose dexamethasone has been shown to reduce mortality in COVID-19 patients requiring oxygen therapy. However, the mechanisms of action of corticosteroids have not been extensively studied in critically ill patients in the context of COVID-19. Plasma biomarkers of inflammatory and immune responses, endothelial and platelet activation, neutrophil extracellular trap formation, and coagulopathy were compared between patients treated or not by systemic dexamethasone for severe forms of COVID-19. Dexamethasone treatment significantly reduced the inflammatory and lymphoid immune response in critical COVID-19 patients but had little effect on the myeloid immune response and no effect on endothelial activation, platelet activation, neutrophil extracellular trap formation, and coagulopathy. The benefits of low dose dexamethasone on outcome in critical COVID-19 can be partially explained by a modulation of the inflammatory response but not by reduction of coagulopathy. Future studies should explore the impact of combining dexamethasone with other immunomodulatory or anticoagulant drugs in severe COVID-19. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1661-6596<br />1422-0067 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: info:eu-repo/semantics/altIdentifier/pmid/37108440; info:eu-repo/semantics/altIdentifier/pissn/1661-6596; info:eu-repo/semantics/altIdentifier/eissn/1422-0067 – Name: DOI Label: DOI Group: ID Data: 10.3390/ijms24087278 – Name: URL Label: Availability Group: URL Data: https://researchportal.unamur.be/en/publications/af9342ce-0515-4af6-858c-5e8f13ad1cc6<br />https://doi.org/10.3390/ijms24087278<br />https://pure.unamur.be/ws/files/79857347/14959_2023_Dechamps.pdf<br />https://www.scopus.com/pages/publications/85156194201 – Name: Copyright Label: Rights Group: Cpyrght Data: info:eu-repo/semantics/openAccess – Name: AN Label: Accession Number Group: ID Data: edsbas.9BC5986B |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/ijms24087278 Languages: – Text: English Subjects: – SubjectFull: Humans Type: general – SubjectFull: Cytokines Type: general – SubjectFull: SARS-CoV-2 Type: general – SubjectFull: Critical Illness Type: general – SubjectFull: COVID-19 Drug Treatment Type: general – SubjectFull: COVID-19/complications Type: general – SubjectFull: Dexamethasone/pharmacology Type: general – SubjectFull: COVID-19 Type: general – SubjectFull: low dose dexamethasone Type: general – SubjectFull: cytokine storm Type: general – SubjectFull: inflammation Type: general – SubjectFull: coagulopathy Type: general Titles: – TitleFull: Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dechamps, Mélanie – PersonEntity: Name: NameFull: De Poortere, Julien – PersonEntity: Name: NameFull: Octave, Marie – PersonEntity: Name: NameFull: Ginion, Audrey – PersonEntity: Name: NameFull: Robaux, Valentine – PersonEntity: Name: NameFull: Pirotton, Laurence – PersonEntity: Name: NameFull: Bodart, Julie – PersonEntity: Name: NameFull: Gruson, Damien – PersonEntity: Name: NameFull: Van Dievoet, Marie-Astrid – PersonEntity: Name: NameFull: Douxfils, Jonathan – PersonEntity: Name: NameFull: Haguet, Hélène – PersonEntity: Name: NameFull: Morimont, Laure – PersonEntity: Name: NameFull: Derive, Marc – PersonEntity: Name: NameFull: Jolly, Lucie – PersonEntity: Name: NameFull: Bertrand, Luc – PersonEntity: Name: NameFull: Laterre, Pierre-François – PersonEntity: Name: NameFull: Horman, Sandrine – PersonEntity: Name: NameFull: Beauloye, Christophe IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16616596 – Type: issn-print Value: 14220067 – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: Dechamps, M, De Poortere, J, Octave, M, Ginion, A, Robaux, V, Pirotton, L, Bodart, J, Gruson, D, Van Dievoet, M-A, Douxfils, J, Haguet, H, Morimont, L, Derive, M, Jolly, L, Bertrand, L, Laterre, P-F, Horman, S & Beauloye, C 2023, 'Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill', International Journal of Molecular Sciences, vol. 24, no. 8, 7278. https://doi.org/10.3390/ijms24087278 Type: main |
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