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Global Effect of Cardiovascular Risk Factors on Lifetime Estimates

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates
Συγγραφείς: Magnussen C., Alegre-Diaz J., Al-Nasser L. A., Amouyel P., Aviles-Santa L., Bakker S. J. L., Ballantyne C. M., Bernabé-Ortiz A., Bobak M., Boffetta P., Brenner H., Brunström M., Can G., Carrillo-Larco R. M., Checkley W., Dallongeville J., De Bacquer D., de Gaetano G., de Lemos J. A., Di Carluccio E., Dobson A., Donfrancesco C., Dörr M., d'Orsi E., Drygas W., Dullaart R. P. F., Engström G., Ferrario M., Ferrières J., Figtree G. A., Gaye B., Ghayour-Mobarhan M., Goldbourt U., Gonzalez C., Gossling A., Grassi G., Gupta P. C., He J., Hodge A. M., Hozawa A., Hveem K., Iacoviello L., Ikram M. K., Inoue M., Irazola V., Jobe M., Jousilahti P., Kaleebu P., Kavousi M., Kee F., Khalili D., Klotsche J., Koenig W., Kontsevaya A., Kowlessur S., Kuri-Morales P., Kuulasmaa K., Kweon S. S., Lackner K. J., Landmesser U., Leistner D. M., Leiva Sisnieguez C. E., Leong D., Lind L., Linneberg A., Lorenz T., Lyngbakken M. N., Malekzadeh R., Malyutina S., Mathiesen E. B., McElduff P., Melander O., Metspalu A., Miranda J. J., Moitry M., Mugisha J., Munzinger J., Nalini M., Nambi V., Nilsson P. M., Ninomiya T., Omland T., Ong S. K., Oppermann K., Pajak A., Palmieri L., Panagiotakos D., Park S. K., Pednekar M. S., Perianayagam A., Peters A., Poustchi H., Prabhakaran D., Prentice A. M., Prescott E., Quyyumi A., Risérus U., Sakata S., Salazar M., Salomaa V., Sans S., Sattler ELP., Schöttker B., Schutte AE., Sepanlou SG., Sharma SK., Shaw J., Simons LA., Söderberg S., Tamosiunas A., Tapia-Conyer R., Thorand B., Tunstall-Pedoe H., Tuomilehto J., Twerenbold R., Vanuzzo D., Veronesi G., Wannamethee SG., Watanabe M., Weimann J., Wild PS., Yao Y., Zeng Y., Ziegler A., Ojeda FM., Blankenberg S.
Συνεισφορές: Magnussen, C., Alegre-Diaz, J., Al-Nasser, L. A., Amouyel, P., Aviles-Santa, L., Bakker, S. J. L., Ballantyne, C. M., Bernabé-Ortiz, A., Bobak, M., Boffetta, P., Brenner, H., Brunström, M., Can, G., Carrillo-Larco, R. M., Checkley, W., Dallongeville, J., De Bacquer, D., De Gaetano, G., De Lemos, J. A., Di Carluccio, E., Dobson, A., Donfrancesco, C., Dörr, M., D'Orsi, E., Drygas, W., Dullaart, R. P. F., Engström, G., Ferrario, M., Ferrières, J., Figtree, G. A., Gaye, B., Ghayour-Mobarhan, M., Goldbourt, U., Gonzalez, C., Gossling, A., Grassi, G., Gupta, P. C., He, J., Hodge, A. M., Hozawa, A., Hveem, K., Iacoviello, L., Ikram, M. K., Inoue, M., Irazola, V., Jobe, M., Jousilahti, P., Kaleebu, P., Kavousi, M., Kee, F., Khalili, D., Klotsche, J., Koenig, W., Kontsevaya, A., Kowlessur, S., Kuri-Morales, P., Kuulasmaa, K., Kweon, S. S., Lackner, K. J., Landmesser, U., Leistner, D. M., Leiva Sisnieguez, C. E., Leong, D., Lind, L., Linneberg, A., Lorenz, T., Lyngbakken, M. N., Malekzadeh, R., Malyutina, S., Mathiesen, E. B., Mcelduff, P., Melander, O., Metspalu, A., Miranda, J. J., Moitry, M., Mugisha, J., Munzinger, J., Nalini, M., Nambi, V., Nilsson, P. M., Ninomiya, T., Omland, T., Ong, S. K., Oppermann, K., Pajak, A., Palmieri, L., Panagiotakos, D., Park, S. K., Pednekar, M. S., Perianayagam, A., Peters, A., Poustchi, H., Prabhakaran, D., Prentice, A. M., Prescott, E., Quyyumi, A., Risérus, U., Sakata, S., Salazar, M., Salomaa, V.
Έτος έκδοσης: 2025
Συλλογή: IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria)
Περιγραφή: BACKGROUND: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear.METHODSWe harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of cardiovascular disease and death from any cause was estimated up to 90 years of age according to the presence or absence of arterial hypertension, hyperlipidemia, underweight and overweight or obesity, diabetes, and smoking at 50 years of age. Differences in life span (in terms of additional life-years free of cardiovascular disease or death from any cause) according to the presence or absence of these risk factors were also estimated. Risk-factor trajectories were analyzed to predict lifetime differences according to risk-factor variation.RESULTSThe lifetime risk of cardiovascular disease was 24% (95% confidence interval [CI], 21 to 30) among women and 38% (95% CI, 30 to 45) among men for whom all five risk factors were present. In the comparison between participants with none of the risk factors and those with all the risk factors, the estimated number of additional life-years free of cardiovascular disease was 13.3 (95% CI, 11.2 to 15.7) for women and 10.6 (95% CI, 9.2 to 12.9) for men; the estimated number of additional life-years free of death was 14.5 (95% CI, 9.1 to 15.3) for women and 11.8 (95% CI, 10.1 to 13.6) for men. As compared with no changes in the presence of all risk factors, modification of hypertension at an age of 55 to less than 60 years was associated with the most additional life-years free of cardiovascular disease, and modification of smoking at an age of 55 to less than 60 years was associated with the most additional life-years free of death.CONCLUSIONSThe absence of five classic risk factors at 50 years of age was associated with more than a decade greater life expectancy than the presence of all ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: ELETTRONICO
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/40162648; info:eu-repo/semantics/altIdentifier/wos/WOS:001567167700007; volume:393; issue:2; firstpage:125; lastpage:138; numberofpages:14; journal:THE NEW ENGLAND JOURNAL OF MEDICINE; https://hdl.handle.net/11383/2197732
DOI: 10.1056/NEJMoa2415879
Διαθεσιμότητα: https://hdl.handle.net/11383/2197732
https://doi.org/10.1056/NEJMoa2415879
Rights: info:eu-repo/semantics/closedAccess ; license:Copyright dell'editore ; license uri:publisher
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Magnussen+C%2E%22">Magnussen C.</searchLink><br /><searchLink fieldCode="AR" term="%22Alegre-Diaz+J%2E%22">Alegre-Diaz J.</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Nasser+L%2E+A%2E%22">Al-Nasser L. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Amouyel+P%2E%22">Amouyel P.</searchLink><br /><searchLink fieldCode="AR" term="%22Aviles-Santa+L%2E%22">Aviles-Santa L.</searchLink><br /><searchLink fieldCode="AR" term="%22Bakker+S%2E+J%2E+L%2E%22">Bakker S. J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ballantyne+C%2E+M%2E%22">Ballantyne C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bernabé-Ortiz+A%2E%22">Bernabé-Ortiz A.</searchLink><br /><searchLink fieldCode="AR" term="%22Bobak+M%2E%22">Bobak M.</searchLink><br /><searchLink fieldCode="AR" term="%22Boffetta+P%2E%22">Boffetta P.</searchLink><br /><searchLink fieldCode="AR" term="%22Brenner+H%2E%22">Brenner H.</searchLink><br /><searchLink fieldCode="AR" term="%22Brunström+M%2E%22">Brunström M.</searchLink><br /><searchLink fieldCode="AR" term="%22Can+G%2E%22">Can G.</searchLink><br /><searchLink fieldCode="AR" term="%22Carrillo-Larco+R%2E+M%2E%22">Carrillo-Larco R. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Checkley+W%2E%22">Checkley W.</searchLink><br /><searchLink fieldCode="AR" term="%22Dallongeville+J%2E%22">Dallongeville J.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Bacquer+D%2E%22">De Bacquer D.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Gaetano+G%2E%22">de Gaetano G.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Lemos+J%2E+A%2E%22">de Lemos J. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Carluccio+E%2E%22">Di Carluccio E.</searchLink><br /><searchLink fieldCode="AR" term="%22Dobson+A%2E%22">Dobson A.</searchLink><br /><searchLink fieldCode="AR" term="%22Donfrancesco+C%2E%22">Donfrancesco C.</searchLink><br /><searchLink fieldCode="AR" term="%22Dörr+M%2E%22">Dörr M.</searchLink><br /><searchLink fieldCode="AR" term="%22d'Orsi+E%2E%22">d'Orsi E.</searchLink><br /><searchLink fieldCode="AR" term="%22Drygas+W%2E%22">Drygas W.</searchLink><br /><searchLink fieldCode="AR" term="%22Dullaart+R%2E+P%2E+F%2E%22">Dullaart R. P. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Engström+G%2E%22">Engström G.</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrario+M%2E%22">Ferrario M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrières+J%2E%22">Ferrières J.</searchLink><br /><searchLink fieldCode="AR" term="%22Figtree+G%2E+A%2E%22">Figtree G. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gaye+B%2E%22">Gaye B.</searchLink><br /><searchLink fieldCode="AR" term="%22Ghayour-Mobarhan+M%2E%22">Ghayour-Mobarhan M.</searchLink><br /><searchLink fieldCode="AR" term="%22Goldbourt+U%2E%22">Goldbourt U.</searchLink><br /><searchLink fieldCode="AR" term="%22Gonzalez+C%2E%22">Gonzalez C.</searchLink><br /><searchLink fieldCode="AR" term="%22Gossling+A%2E%22">Gossling A.</searchLink><br /><searchLink fieldCode="AR" term="%22Grassi+G%2E%22">Grassi G.</searchLink><br /><searchLink fieldCode="AR" term="%22Gupta+P%2E+C%2E%22">Gupta P. C.</searchLink><br /><searchLink fieldCode="AR" term="%22He+J%2E%22">He J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hodge+A%2E+M%2E%22">Hodge A. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hozawa+A%2E%22">Hozawa A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hveem+K%2E%22">Hveem K.</searchLink><br /><searchLink fieldCode="AR" term="%22Iacoviello+L%2E%22">Iacoviello L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ikram+M%2E+K%2E%22">Ikram M. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Inoue+M%2E%22">Inoue M.</searchLink><br /><searchLink fieldCode="AR" term="%22Irazola+V%2E%22">Irazola V.</searchLink><br /><searchLink fieldCode="AR" term="%22Jobe+M%2E%22">Jobe M.</searchLink><br /><searchLink fieldCode="AR" term="%22Jousilahti+P%2E%22">Jousilahti P.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaleebu+P%2E%22">Kaleebu P.</searchLink><br /><searchLink fieldCode="AR" term="%22Kavousi+M%2E%22">Kavousi M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kee+F%2E%22">Kee F.</searchLink><br /><searchLink fieldCode="AR" term="%22Khalili+D%2E%22">Khalili D.</searchLink><br /><searchLink fieldCode="AR" term="%22Klotsche+J%2E%22">Klotsche J.</searchLink><br /><searchLink fieldCode="AR" term="%22Koenig+W%2E%22">Koenig W.</searchLink><br /><searchLink fieldCode="AR" term="%22Kontsevaya+A%2E%22">Kontsevaya A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kowlessur+S%2E%22">Kowlessur S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kuri-Morales+P%2E%22">Kuri-Morales P.</searchLink><br /><searchLink fieldCode="AR" term="%22Kuulasmaa+K%2E%22">Kuulasmaa K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kweon+S%2E+S%2E%22">Kweon S. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lackner+K%2E+J%2E%22">Lackner K. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Landmesser+U%2E%22">Landmesser U.</searchLink><br /><searchLink fieldCode="AR" term="%22Leistner+D%2E+M%2E%22">Leistner D. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Leiva+Sisnieguez+C%2E+E%2E%22">Leiva Sisnieguez C. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Leong+D%2E%22">Leong D.</searchLink><br /><searchLink fieldCode="AR" term="%22Lind+L%2E%22">Lind L.</searchLink><br /><searchLink fieldCode="AR" term="%22Linneberg+A%2E%22">Linneberg A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lorenz+T%2E%22">Lorenz T.</searchLink><br /><searchLink fieldCode="AR" term="%22Lyngbakken+M%2E+N%2E%22">Lyngbakken M. N.</searchLink><br /><searchLink fieldCode="AR" term="%22Malekzadeh+R%2E%22">Malekzadeh R.</searchLink><br /><searchLink fieldCode="AR" term="%22Malyutina+S%2E%22">Malyutina S.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathiesen+E%2E+B%2E%22">Mathiesen E. B.</searchLink><br /><searchLink fieldCode="AR" term="%22McElduff+P%2E%22">McElduff P.</searchLink><br /><searchLink fieldCode="AR" term="%22Melander+O%2E%22">Melander O.</searchLink><br /><searchLink fieldCode="AR" term="%22Metspalu+A%2E%22">Metspalu A.</searchLink><br /><searchLink fieldCode="AR" term="%22Miranda+J%2E+J%2E%22">Miranda J. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Moitry+M%2E%22">Moitry M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mugisha+J%2E%22">Mugisha J.</searchLink><br /><searchLink fieldCode="AR" term="%22Munzinger+J%2E%22">Munzinger J.</searchLink><br /><searchLink fieldCode="AR" term="%22Nalini+M%2E%22">Nalini M.</searchLink><br /><searchLink fieldCode="AR" term="%22Nambi+V%2E%22">Nambi V.</searchLink><br /><searchLink fieldCode="AR" term="%22Nilsson+P%2E+M%2E%22">Nilsson P. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ninomiya+T%2E%22">Ninomiya T.</searchLink><br /><searchLink fieldCode="AR" term="%22Omland+T%2E%22">Omland T.</searchLink><br /><searchLink fieldCode="AR" term="%22Ong+S%2E+K%2E%22">Ong S. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Oppermann+K%2E%22">Oppermann K.</searchLink><br /><searchLink fieldCode="AR" term="%22Pajak+A%2E%22">Pajak A.</searchLink><br /><searchLink fieldCode="AR" term="%22Palmieri+L%2E%22">Palmieri L.</searchLink><br /><searchLink fieldCode="AR" term="%22Panagiotakos+D%2E%22">Panagiotakos D.</searchLink><br /><searchLink fieldCode="AR" term="%22Park+S%2E+K%2E%22">Park S. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Pednekar+M%2E+S%2E%22">Pednekar M. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Perianayagam+A%2E%22">Perianayagam A.</searchLink><br /><searchLink fieldCode="AR" term="%22Peters+A%2E%22">Peters A.</searchLink><br /><searchLink fieldCode="AR" term="%22Poustchi+H%2E%22">Poustchi H.</searchLink><br /><searchLink fieldCode="AR" term="%22Prabhakaran+D%2E%22">Prabhakaran D.</searchLink><br /><searchLink fieldCode="AR" term="%22Prentice+A%2E+M%2E%22">Prentice A. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Prescott+E%2E%22">Prescott E.</searchLink><br /><searchLink fieldCode="AR" term="%22Quyyumi+A%2E%22">Quyyumi A.</searchLink><br /><searchLink fieldCode="AR" term="%22Risérus+U%2E%22">Risérus U.</searchLink><br /><searchLink fieldCode="AR" term="%22Sakata+S%2E%22">Sakata S.</searchLink><br /><searchLink fieldCode="AR" term="%22Salazar+M%2E%22">Salazar M.</searchLink><br /><searchLink fieldCode="AR" term="%22Salomaa+V%2E%22">Salomaa V.</searchLink><br /><searchLink fieldCode="AR" term="%22Sans+S%2E%22">Sans S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sattler+ELP%2E%22">Sattler ELP.</searchLink><br /><searchLink fieldCode="AR" term="%22Schöttker+B%2E%22">Schöttker B.</searchLink><br /><searchLink fieldCode="AR" term="%22Schutte+AE%2E%22">Schutte AE.</searchLink><br /><searchLink fieldCode="AR" term="%22Sepanlou+SG%2E%22">Sepanlou SG.</searchLink><br /><searchLink fieldCode="AR" term="%22Sharma+SK%2E%22">Sharma SK.</searchLink><br /><searchLink fieldCode="AR" term="%22Shaw+J%2E%22">Shaw J.</searchLink><br /><searchLink fieldCode="AR" term="%22Simons+LA%2E%22">Simons LA.</searchLink><br /><searchLink fieldCode="AR" term="%22Söderberg+S%2E%22">Söderberg S.</searchLink><br /><searchLink fieldCode="AR" term="%22Tamosiunas+A%2E%22">Tamosiunas A.</searchLink><br /><searchLink fieldCode="AR" term="%22Tapia-Conyer+R%2E%22">Tapia-Conyer R.</searchLink><br /><searchLink fieldCode="AR" term="%22Thorand+B%2E%22">Thorand B.</searchLink><br /><searchLink fieldCode="AR" term="%22Tunstall-Pedoe+H%2E%22">Tunstall-Pedoe H.</searchLink><br /><searchLink fieldCode="AR" term="%22Tuomilehto+J%2E%22">Tuomilehto J.</searchLink><br /><searchLink fieldCode="AR" term="%22Twerenbold+R%2E%22">Twerenbold R.</searchLink><br /><searchLink fieldCode="AR" term="%22Vanuzzo+D%2E%22">Vanuzzo D.</searchLink><br /><searchLink fieldCode="AR" term="%22Veronesi+G%2E%22">Veronesi G.</searchLink><br /><searchLink fieldCode="AR" term="%22Wannamethee+SG%2E%22">Wannamethee SG.</searchLink><br /><searchLink fieldCode="AR" term="%22Watanabe+M%2E%22">Watanabe M.</searchLink><br /><searchLink fieldCode="AR" term="%22Weimann+J%2E%22">Weimann J.</searchLink><br /><searchLink fieldCode="AR" term="%22Wild+PS%2E%22">Wild PS.</searchLink><br /><searchLink fieldCode="AR" term="%22Yao+Y%2E%22">Yao Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Zeng+Y%2E%22">Zeng Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Ziegler+A%2E%22">Ziegler A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ojeda+FM%2E%22">Ojeda FM.</searchLink><br /><searchLink fieldCode="AR" term="%22Blankenberg+S%2E%22">Blankenberg S.</searchLink>
– Name: Author
  Label: Contributors
  Group: Au
  Data: Magnussen, C.<br />Alegre-Diaz, J.<br />Al-Nasser, L. A.<br />Amouyel, P.<br />Aviles-Santa, L.<br />Bakker, S. J. L.<br />Ballantyne, C. M.<br />Bernabé-Ortiz, A.<br />Bobak, M.<br />Boffetta, P.<br />Brenner, H.<br />Brunström, M.<br />Can, G.<br />Carrillo-Larco, R. M.<br />Checkley, W.<br />Dallongeville, J.<br />De Bacquer, D.<br />De Gaetano, G.<br />De Lemos, J. A.<br />Di Carluccio, E.<br />Dobson, A.<br />Donfrancesco, C.<br />Dörr, M.<br />D'Orsi, E.<br />Drygas, W.<br />Dullaart, R. P. F.<br />Engström, G.<br />Ferrario, M.<br />Ferrières, J.<br />Figtree, G. A.<br />Gaye, B.<br />Ghayour-Mobarhan, M.<br />Goldbourt, U.<br />Gonzalez, C.<br />Gossling, A.<br />Grassi, G.<br />Gupta, P. C.<br />He, J.<br />Hodge, A. M.<br />Hozawa, A.<br />Hveem, K.<br />Iacoviello, L.<br />Ikram, M. K.<br />Inoue, M.<br />Irazola, V.<br />Jobe, M.<br />Jousilahti, P.<br />Kaleebu, P.<br />Kavousi, M.<br />Kee, F.<br />Khalili, D.<br />Klotsche, J.<br />Koenig, W.<br />Kontsevaya, A.<br />Kowlessur, S.<br />Kuri-Morales, P.<br />Kuulasmaa, K.<br />Kweon, S. S.<br />Lackner, K. J.<br />Landmesser, U.<br />Leistner, D. M.<br />Leiva Sisnieguez, C. E.<br />Leong, D.<br />Lind, L.<br />Linneberg, A.<br />Lorenz, T.<br />Lyngbakken, M. N.<br />Malekzadeh, R.<br />Malyutina, S.<br />Mathiesen, E. B.<br />Mcelduff, P.<br />Melander, O.<br />Metspalu, A.<br />Miranda, J. J.<br />Moitry, M.<br />Mugisha, J.<br />Munzinger, J.<br />Nalini, M.<br />Nambi, V.<br />Nilsson, P. M.<br />Ninomiya, T.<br />Omland, T.<br />Ong, S. K.<br />Oppermann, K.<br />Pajak, A.<br />Palmieri, L.<br />Panagiotakos, D.<br />Park, S. K.<br />Pednekar, M. S.<br />Perianayagam, A.<br />Peters, A.<br />Poustchi, H.<br />Prabhakaran, D.<br />Prentice, A. M.<br />Prescott, E.<br />Quyyumi, A.<br />Risérus, U.<br />Sakata, S.<br />Salazar, M.<br />Salomaa, V.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria)
– Name: Abstract
  Label: Description
  Group: Ab
  Data: BACKGROUND: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear.METHODSWe harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of cardiovascular disease and death from any cause was estimated up to 90 years of age according to the presence or absence of arterial hypertension, hyperlipidemia, underweight and overweight or obesity, diabetes, and smoking at 50 years of age. Differences in life span (in terms of additional life-years free of cardiovascular disease or death from any cause) according to the presence or absence of these risk factors were also estimated. Risk-factor trajectories were analyzed to predict lifetime differences according to risk-factor variation.RESULTSThe lifetime risk of cardiovascular disease was 24% (95% confidence interval [CI], 21 to 30) among women and 38% (95% CI, 30 to 45) among men for whom all five risk factors were present. In the comparison between participants with none of the risk factors and those with all the risk factors, the estimated number of additional life-years free of cardiovascular disease was 13.3 (95% CI, 11.2 to 15.7) for women and 10.6 (95% CI, 9.2 to 12.9) for men; the estimated number of additional life-years free of death was 14.5 (95% CI, 9.1 to 15.3) for women and 11.8 (95% CI, 10.1 to 13.6) for men. As compared with no changes in the presence of all risk factors, modification of hypertension at an age of 55 to less than 60 years was associated with the most additional life-years free of cardiovascular disease, and modification of smoking at an age of 55 to less than 60 years was associated with the most additional life-years free of death.CONCLUSIONSThe absence of five classic risk factors at 50 years of age was associated with more than a decade greater life expectancy than the presence of all ...
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  Data: English
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  Data: info:eu-repo/semantics/altIdentifier/pmid/40162648; info:eu-repo/semantics/altIdentifier/wos/WOS:001567167700007; volume:393; issue:2; firstpage:125; lastpage:138; numberofpages:14; journal:THE NEW ENGLAND JOURNAL OF MEDICINE; https://hdl.handle.net/11383/2197732
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1056/NEJMoa2415879
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  Data: https://hdl.handle.net/11383/2197732<br />https://doi.org/10.1056/NEJMoa2415879
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  Data: info:eu-repo/semantics/closedAccess ; license:Copyright dell'editore ; license uri:publisher
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  Data: edsbas.965C2BCF
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      – TitleFull: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates
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              M: 01
              Type: published
              Y: 2025
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              Value: edsbas
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