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Design of a force-measuring setup for colorectal compression anastomosis and first ex-vivo results

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Design of a force-measuring setup for colorectal compression anastomosis and first ex-vivo results
Συγγραφείς: Steger, Jana, Patzke, Isabella, Berlet, Maximilian, Ficht, Stefanie, Eblenkamp, Markus, Mela, Petra, Wilhelm, Dirk
Πηγή: http://lobid.org/resources/99370675073906441#!, 16(8):1335-1345.
Έτος έκδοσης: 2021
Συλλογή: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Θεματικοί όροι: Colonoscopy/methods [MeSH], Swine [MeSH], Pressure [MeSH], Rectum/surgery [MeSH], Colon, Colorectal Neoplasms/surgery [MeSH], Biomechanical Phenomena [MeSH], Forces, Colorectal Neoplasms/physiopathology [MeSH], Animals [MeSH], Original Article, Anastomosis, Surgical/methods [MeSH], Implants, Neoplasms, Experimental [MeSH], Digestive System Surgical Procedures/methods [MeSH], Endoscopy, Piercing
Περιγραφή: Purpose!#!The introduction of novel endoscopic instruments is essential to reduce trauma in visceral surgery. However, endoscopic device development is hampered by challenges in respecting the dimensional restrictions, due to the narrow access route, and by achieving adequate force transmission. As the overall goal of our research is the development of a patient adaptable, endoscopic anastomosis manipulator, biomechanical and size-related characterization of gastrointestinal organs are needed to determine technical requirements and thresholds to define functional design and load-compatible dimensioning of devices.!##!Methods!#!We built an experimental setup to measure colon tissue compression piercing forces. We tested 54 parameter sets, including variations of three tissue fixation configurations, three piercing body configurations (four, eight, twelve spikes) and insertion trajectories of constant velocities (5 mms!##!Results!#!There was no statistically significant difference in insertion forces neither between the trajectory groups, nor for variation of tissue fixation configurations. However, we observed a statistically significant increase in insertion forces for increasing number of spikes. The maximum mean peak forces for four, eight and twelve spikes were 6.4 ± 1.5 N, 13.6 ± 1.4 N and 21.7 ± 5.8 N, respectively. The 5th percentile of specimen lumen diameters and pierced tissue thickness were 24.1 mm and 2.8 mm, and the 95th percentiles 40.1 mm and 4.8 mm, respectively.!##!Conclusion!#!The setup enabled reliable biomechanical characterization of colon material, on the base of which design specifications for an endoscopic anastomosis device were derived. The axial implant closure unit must enable axial force transmission of at least 28 N (22 ± 6 N). Implant and applicator diameters must cover a range between 24 and 40 mm, and the implant gap, compressing anastomosed tissue, between 2 and 5 mm.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://repository.publisso.de/resource/frl:6444539; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295116/
DOI: 10.1007/s11548-021-02371-8
Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6444539
https://doi.org/10.1007/s11548-021-02371-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295116/
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.9519FDFA
Βάση Δεδομένων: BASE
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  Data: Design of a force-measuring setup for colorectal compression anastomosis and first ex-vivo results
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  Data: <searchLink fieldCode="AR" term="%22Steger%2C+Jana%22">Steger, Jana</searchLink><br /><searchLink fieldCode="AR" term="%22Patzke%2C+Isabella%22">Patzke, Isabella</searchLink><br /><searchLink fieldCode="AR" term="%22Berlet%2C+Maximilian%22">Berlet, Maximilian</searchLink><br /><searchLink fieldCode="AR" term="%22Ficht%2C+Stefanie%22">Ficht, Stefanie</searchLink><br /><searchLink fieldCode="AR" term="%22Eblenkamp%2C+Markus%22">Eblenkamp, Markus</searchLink><br /><searchLink fieldCode="AR" term="%22Mela%2C+Petra%22">Mela, Petra</searchLink><br /><searchLink fieldCode="AR" term="%22Wilhelm%2C+Dirk%22">Wilhelm, Dirk</searchLink>
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  Data: <i>http://lobid.org/resources/99370675073906441#!, 16(8):1335-1345</i>.
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  Data: <searchLink fieldCode="DE" term="%22Colonoscopy%2Fmethods+[MeSH]%22">Colonoscopy/methods [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Swine+[MeSH]%22">Swine [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Pressure+[MeSH]%22">Pressure [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Rectum%2Fsurgery+[MeSH]%22">Rectum/surgery [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Colon%22">Colon</searchLink><br /><searchLink fieldCode="DE" term="%22Colorectal+Neoplasms%2Fsurgery+[MeSH]%22">Colorectal Neoplasms/surgery [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanical+Phenomena+[MeSH]%22">Biomechanical Phenomena [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Forces%22">Forces</searchLink><br /><searchLink fieldCode="DE" term="%22Colorectal+Neoplasms%2Fphysiopathology+[MeSH]%22">Colorectal Neoplasms/physiopathology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Animals+[MeSH]%22">Animals [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Original+Article%22">Original Article</searchLink><br /><searchLink fieldCode="DE" term="%22Anastomosis%22">Anastomosis</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical%2Fmethods+[MeSH]%22">Surgical/methods [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Implants%22">Implants</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%22">Neoplasms</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+[MeSH]%22">Experimental [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Digestive+System+Surgical+Procedures%2Fmethods+[MeSH]%22">Digestive System Surgical Procedures/methods [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Endoscopy%22">Endoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Piercing%22">Piercing</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Purpose!#!The introduction of novel endoscopic instruments is essential to reduce trauma in visceral surgery. However, endoscopic device development is hampered by challenges in respecting the dimensional restrictions, due to the narrow access route, and by achieving adequate force transmission. As the overall goal of our research is the development of a patient adaptable, endoscopic anastomosis manipulator, biomechanical and size-related characterization of gastrointestinal organs are needed to determine technical requirements and thresholds to define functional design and load-compatible dimensioning of devices.!##!Methods!#!We built an experimental setup to measure colon tissue compression piercing forces. We tested 54 parameter sets, including variations of three tissue fixation configurations, three piercing body configurations (four, eight, twelve spikes) and insertion trajectories of constant velocities (5 mms!##!Results!#!There was no statistically significant difference in insertion forces neither between the trajectory groups, nor for variation of tissue fixation configurations. However, we observed a statistically significant increase in insertion forces for increasing number of spikes. The maximum mean peak forces for four, eight and twelve spikes were 6.4 ± 1.5 N, 13.6 ± 1.4 N and 21.7 ± 5.8 N, respectively. The 5th percentile of specimen lumen diameters and pierced tissue thickness were 24.1 mm and 2.8 mm, and the 95th percentiles 40.1 mm and 4.8 mm, respectively.!##!Conclusion!#!The setup enabled reliable biomechanical characterization of colon material, on the base of which design specifications for an endoscopic anastomosis device were derived. The axial implant closure unit must enable axial force transmission of at least 28 N (22 ± 6 N). Implant and applicator diameters must cover a range between 24 and 40 mm, and the implant gap, compressing anastomosed tissue, between 2 and 5 mm.
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  Data: https://repository.publisso.de/resource/frl:6444539; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295116/
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  Data: 10.1007/s11548-021-02371-8
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        Value: 10.1007/s11548-021-02371-8
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      – Text: English
    Subjects:
      – SubjectFull: Colonoscopy/methods [MeSH]
        Type: general
      – SubjectFull: Swine [MeSH]
        Type: general
      – SubjectFull: Pressure [MeSH]
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      – SubjectFull: Rectum/surgery [MeSH]
        Type: general
      – SubjectFull: Colon
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      – SubjectFull: Colorectal Neoplasms/surgery [MeSH]
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      – SubjectFull: Implants
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      – SubjectFull: Digestive System Surgical Procedures/methods [MeSH]
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      – SubjectFull: Endoscopy
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      – SubjectFull: Piercing
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      – TitleFull: Design of a force-measuring setup for colorectal compression anastomosis and first ex-vivo results
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