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Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

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Τίτλος: Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome
Συγγραφείς: Catello Giordano, Jonatan Kendler, Maximilian Sexl, Sebastian Kollman, Maxim Varenicja, Boglárka Szabó, Gerald Timelthaler, Dominik Kirchhofer, Oldamur Hollóczki, Suzanne D. Turner, Richard Moriggl, Lukas Kenner, Mohamed Touaibia, Olaf Merkel
Πηγή: issn:2213-2317 ; Redox Biology.
Στοιχεία εκδότη: Elsevier
Έτος έκδοσης: 2025
Θεματικοί όροι: Humans, Caffeic Acids Pharmacology, Caffeic Acids Chemistry, Phenylethyl Alcohol Analogs & Derivatives, Phenylethyl Alcohol Pharmacology, Phenylethyl Alcohol Chemistry, Centrosome Drug Effects, Centrosome Metabolism, Antineoplastic Agents Pharmacology, Antineoplastic Agents Chemistry, Apoptosis Drug Effects, Cell Line, Tumor, Cell Proliferation Drug Effects
Περιγραφή: Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal ?-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publikationen]; https://phaidra.vetmeduni.ac.at/o:4027
DOI: 10.1016/j.redox.2025.103582
Διαθεσιμότητα: https://doi.org/10.1016/j.redox.2025.103582
https://phaidra.vetmeduni.ac.at/o:4027
Rights: http://creativecommons.org/licenses/by/4.0/ ; Copyright © 2025 The Authors ; open access
Αριθμός Καταχώρησης: edsbas.8EEDA899
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.1016/j.redox.2025.103582#
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  Data: Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome
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  Data: <searchLink fieldCode="AR" term="%22Catello+Giordano%22">Catello Giordano</searchLink><br /><searchLink fieldCode="AR" term="%22Jonatan+Kendler%22">Jonatan Kendler</searchLink><br /><searchLink fieldCode="AR" term="%22Maximilian+Sexl%22">Maximilian Sexl</searchLink><br /><searchLink fieldCode="AR" term="%22Sebastian+Kollman%22">Sebastian Kollman</searchLink><br /><searchLink fieldCode="AR" term="%22Maxim+Varenicja%22">Maxim Varenicja</searchLink><br /><searchLink fieldCode="AR" term="%22Boglárka+Szabó%22">Boglárka Szabó</searchLink><br /><searchLink fieldCode="AR" term="%22Gerald+Timelthaler%22">Gerald Timelthaler</searchLink><br /><searchLink fieldCode="AR" term="%22Dominik+Kirchhofer%22">Dominik Kirchhofer</searchLink><br /><searchLink fieldCode="AR" term="%22Oldamur+Hollóczki%22">Oldamur Hollóczki</searchLink><br /><searchLink fieldCode="AR" term="%22Suzanne+D%2E+Turner%22">Suzanne D. Turner</searchLink><br /><searchLink fieldCode="AR" term="%22Richard+Moriggl%22">Richard Moriggl</searchLink><br /><searchLink fieldCode="AR" term="%22Lukas+Kenner%22">Lukas Kenner</searchLink><br /><searchLink fieldCode="AR" term="%22Mohamed+Touaibia%22">Mohamed Touaibia</searchLink><br /><searchLink fieldCode="AR" term="%22Olaf+Merkel%22">Olaf Merkel</searchLink>
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  Data: 2025
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  Data: Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal ?-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies.
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  Data: 10.1016/j.redox.2025.103582
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  Data: https://doi.org/10.1016/j.redox.2025.103582<br />https://phaidra.vetmeduni.ac.at/o:4027
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      – Text: English
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