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Effect of the neuroinflammatory drug class glucocorticoids on specific cognitive functions

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effect of the neuroinflammatory drug class glucocorticoids on specific cognitive functions
Συγγραφείς: Hajjaj, Salima
Στοιχεία εκδότη: Zenodo
Έτος έκδοσης: 2025
Συλλογή: Zenodo
Θεματικοί όροι: Neurocognitive Disorders, Glucocorticoids, Prefrontal Cortex/metabolism, HPA axis, Psychoneuroendocrinology, Neuropsychology, Neuroendocrinology, Cognitive impairment, postoperative cognitive dysfunction (POCD), post-traumatic stress disorder (PTSD), chronic multisymptom illness (CMI), Dexamethasone, Dexamethasone/pharmacology, Mifepristone, declarative memory, working memory, Attention, cognitive functions, synthetic glucocorticoids, randomized controlled trials, Hydrocortisone, stress response, systematic review
Περιγραφή: This thesis presents a systematic review of randomized controlled trials (RCTs) investigating the effects of synthetic glucocorticoids (GCs) on human cognitive functions. Based on 33 eligible RCTs, the study critically examines the role of GCs in modulating memory, attention, and executive functioning across different clinical and non-clinical populations. Following PRISMA guidelines and using the Cochrane Risk of Bias 2.0 tool, studies were assessed for methodological quality and categorized by domain (e.g., declarative memory, working memory) and population (e.g., POCD, PTSD, bipolar disorder). The findings suggest dose- and context-dependent cognitive effects of glucocorticoids, with both detrimental and potentially beneficial outcomes depending on dosage, timing, and underlying neurobiological mechanisms. Notably, the results indicate increased cognitive vulnerability in populations with stress-related disorders such as PTSD, where glucocorticoid sensitivity and hippocampal function may play a key role. This work contributes to the understanding of neuroendocrine-cognitive interactions and highlights clinical implications for the use of synthetic GCs. It also identifies limitations in the current literature and provides directions for future research on dosing strategies, long-term effects, and neurobiological pathways.
Τύπος εγγράφου: text
Γλώσσα: English
Relation: https://zenodo.org/records/15864344; oai:zenodo.org:15864344; https://doi.org/10.5281/zenodo.15864344
DOI: 10.5281/zenodo.15864344
Διαθεσιμότητα: https://doi.org/10.5281/zenodo.15864344
https://zenodo.org/records/15864344
Rights: Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode ; © Salima Hajjaj, 2025. Licensed under CC BY 4.0
Αριθμός Καταχώρησης: edsbas.8AD2FF2D
Βάση Δεδομένων: BASE
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  Data: Effect of the neuroinflammatory drug class glucocorticoids on specific cognitive functions
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22Neurocognitive+Disorders%22">Neurocognitive Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Glucocorticoids%22">Glucocorticoids</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+Cortex%2Fmetabolism%22">Prefrontal Cortex/metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22HPA+axis%22">HPA axis</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoneuroendocrinology%22">Psychoneuroendocrinology</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroendocrinology%22">Neuroendocrinology</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+impairment%22">Cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22postoperative+cognitive+dysfunction+%28POCD%29%22">postoperative cognitive dysfunction (POCD)</searchLink><br /><searchLink fieldCode="DE" term="%22post-traumatic+stress+disorder+%28PTSD%29%22">post-traumatic stress disorder (PTSD)</searchLink><br /><searchLink fieldCode="DE" term="%22chronic+multisymptom+illness+%28CMI%29%22">chronic multisymptom illness (CMI)</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone%22">Dexamethasone</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone%2Fpharmacology%22">Dexamethasone/pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Mifepristone%22">Mifepristone</searchLink><br /><searchLink fieldCode="DE" term="%22declarative+memory%22">declarative memory</searchLink><br /><searchLink fieldCode="DE" term="%22working+memory%22">working memory</searchLink><br /><searchLink fieldCode="DE" term="%22Attention%22">Attention</searchLink><br /><searchLink fieldCode="DE" term="%22cognitive+functions%22">cognitive functions</searchLink><br /><searchLink fieldCode="DE" term="%22synthetic+glucocorticoids%22">synthetic glucocorticoids</searchLink><br /><searchLink fieldCode="DE" term="%22randomized+controlled+trials%22">randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocortisone%22">Hydrocortisone</searchLink><br /><searchLink fieldCode="DE" term="%22stress+response%22">stress response</searchLink><br /><searchLink fieldCode="DE" term="%22systematic+review%22">systematic review</searchLink>
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  Data: This thesis presents a systematic review of randomized controlled trials (RCTs) investigating the effects of synthetic glucocorticoids (GCs) on human cognitive functions. Based on 33 eligible RCTs, the study critically examines the role of GCs in modulating memory, attention, and executive functioning across different clinical and non-clinical populations. Following PRISMA guidelines and using the Cochrane Risk of Bias 2.0 tool, studies were assessed for methodological quality and categorized by domain (e.g., declarative memory, working memory) and population (e.g., POCD, PTSD, bipolar disorder). The findings suggest dose- and context-dependent cognitive effects of glucocorticoids, with both detrimental and potentially beneficial outcomes depending on dosage, timing, and underlying neurobiological mechanisms. Notably, the results indicate increased cognitive vulnerability in populations with stress-related disorders such as PTSD, where glucocorticoid sensitivity and hippocampal function may play a key role. This work contributes to the understanding of neuroendocrine-cognitive interactions and highlights clinical implications for the use of synthetic GCs. It also identifies limitations in the current literature and provides directions for future research on dosing strategies, long-term effects, and neurobiological pathways.
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  Data: Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode ; © Salima Hajjaj, 2025. Licensed under CC BY 4.0
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        Value: 10.5281/zenodo.15864344
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      – Text: English
    Subjects:
      – SubjectFull: Neurocognitive Disorders
        Type: general
      – SubjectFull: Glucocorticoids
        Type: general
      – SubjectFull: Prefrontal Cortex/metabolism
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      – SubjectFull: HPA axis
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      – SubjectFull: Psychoneuroendocrinology
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      – SubjectFull: Neuroendocrinology
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      – SubjectFull: Cognitive impairment
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      – SubjectFull: postoperative cognitive dysfunction (POCD)
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      – SubjectFull: post-traumatic stress disorder (PTSD)
        Type: general
      – SubjectFull: chronic multisymptom illness (CMI)
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      – SubjectFull: Dexamethasone
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      – SubjectFull: Dexamethasone/pharmacology
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      – SubjectFull: Mifepristone
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      – SubjectFull: declarative memory
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      – SubjectFull: working memory
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      – SubjectFull: Attention
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      – SubjectFull: cognitive functions
        Type: general
      – SubjectFull: synthetic glucocorticoids
        Type: general
      – SubjectFull: randomized controlled trials
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      – SubjectFull: Hydrocortisone
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      – SubjectFull: stress response
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      – SubjectFull: systematic review
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      – TitleFull: Effect of the neuroinflammatory drug class glucocorticoids on specific cognitive functions
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              Y: 2025
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