Academic Journal
Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis
| Τίτλος: | Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis |
|---|---|
| Συγγραφείς: | Zhang, Weiting, Scerbo, Pierluigi, Delagrange, Marine, Candat, Virginie, Mayr, Vanessa, Vriz, Sophie, Distel, Martin, Ducos, Bertrand, Bensimon, David |
| Συνεισφορές: | ABCD : Biophysique des Biomolécules, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL), Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS-PSL (IBENS), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), St. Anna Children’s Cancer Research Institute CCRI Vienna, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry and Biochemistry Los Angeles, University of California Los Angeles (UCLA), University of California (UC)-University of California (UC), ANR-10-LABX-0054,MEMOLIFE,Memory in living systems: an integrated approach(2010) |
| Πηγή: | ISSN: 2399-3642 ; Communications Biology ; https://hal.science/hal-03727212 ; Communications Biology, 2022, 5 (1), pp.113. ⟨10.1038/s42003-022-03053-0⟩ ; https://www.nature.com/articles/s42003-022-03053-0. |
| Στοιχεία εκδότη: | CCSD Nature Publishing Group |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | Embryonic induction, Body patterning, MESH: Animals, MESH: Embryo, Nonmammalian / metabolism, MESH: RNA, Messenger / metabolism, MESH: Zebrafish, MESH: p-Aminoazobenzene / analogs & derivatives, MESH: p-Aminoazobenzene / pharmacology, MESH: Embryonic Development / genetics, MESH: Embryonic Development / physiology, MESH: Fibroblast Growth Factor 8 / genetics, MESH: Fibroblast Growth Factor 8 / metabolism, MESH: Gene Expression Regulation, Developmental / physiology, Messenger / genetics, [PHYS]Physics [physics], [SDV]Life Sciences [q-bio] |
| Περιγραφή: | International audience ; Somitogenesis, the segmentation of the antero-posterior axis in vertebrates, is thought to result from the interactions between a genetic oscillator and a posterior-moving determination wavefront. The segment (somite) size is set by the product of the oscillator period and the velocity of the determination wavefront. Surprisingly, while the segmentation period can vary by a factor three between 20 °C and 32 °C, the somite size is constant. How this temperature independence is achieved is a mystery that we address in this study. Using RT-qPCR we show that the endogenous fgf8 mRNA concentration decreases during somitogenesis and correlates with the exponent of the shrinking pre-somitic mesoderm (PSM) size. As the temperature decreases, the dynamics of fgf8 and many other gene transcripts, as well as the segmentation frequency and the PSM shortening and tail growth rates slows down as T–T c (with T c = 14.4 °C). This behavior characteristic of a system near a critical point may account for the temperature independence of somitogenesis in zebrafish. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35132142; PUBMED: 35132142; PUBMEDCENTRAL: PMC8821593 |
| DOI: | 10.1038/s42003-022-03053-0 |
| Διαθεσιμότητα: | https://hal.science/hal-03727212 https://hal.science/hal-03727212v1/document https://hal.science/hal-03727212v1/file/s42003-022-03053-0.pdf https://doi.org/10.1038/s42003-022-03053-0 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Αριθμός Καταχώρησης: | edsbas.847450B5 |
| Βάση Δεδομένων: | BASE |
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