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Association between ustekinumab therapy and changes in specific anti-microbial response, serum biomarkers, and microbiota composition in patients with IBD: A pilot study

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Title: Association between ustekinumab therapy and changes in specific anti-microbial response, serum biomarkers, and microbiota composition in patients with IBD: A pilot study
Authors: Rob, Filip, Schierova, Dagmar, Stehlikova, Zuzana, Kreisinger, Jakub, Roubalova, Radka, Coufal, Stepan, Mihula, Martin, Jackova, Zuzana, Kverka, Miloslav, Thon, Tomas, Kostovcikova, Klara, Bajer, Lukas, Drastich, Pavel, Hercogova, Jana Tresnak, Novakova, Michaela, Kolar, Martin, Vasatko, Martin, Lukas, Milan, Tlaskalova-Hogenova, Helena, Jiraskova Zakostelska, Zuzana
Contributors: Staley, Christopher, Ministerstvo Zdravotnictví Ceské Republiky, Mikrobiologický Ústav, Akademie Věd České Republiky
Source: PLOS ONE ; volume 17, issue 12, page e0277576 ; ISSN 1932-6203
Publisher Information: Public Library of Science (PLoS)
Publication Year: 2022
Collection: PLOS Publications (via CrossRef)
Description: Background Ustekinumab, is a new therapy for patients with IBD, especially for patients suffering from Crohn’s disease (CD) who did not respond to anti-TNF treatment. To shed light on the longitudinal effect of ustekinumab on the immune system, we investigated the effect on skin and gut microbiota composition, specific immune response to commensals, and various serum biomarkers. Methodology/Principal findings We recruited 11 patients with IBD who were monitored over 40 weeks of ustekinumab therapy and 39 healthy controls (HC). We found differences in the concentrations of serum levels of osteoprotegerin, TGF-β1, IL-33, and serum IgM antibodies against Lactobacillus plantarum between patients with IBD and HC. The levels of these biomarkers did not change in response to ustekinumab treatment or with disease improvement during the 40 weeks of observation. Additionally, we identified differences in stool abundance of uncultured Subdoligranulum , Faecalibacterium , and Bacteroides between patients with IBD and HC. Conclusion/Significance In this preliminary study, we provide a unique overview of the longitudinal monitoring of fecal and skin microbial profiles as well as various serum biomarkers and humoral and cellular response to gut commensals in a small cohort of patients with IBD on ustekinumab therapy.
Document Type: article in journal/newspaper
Language: English
DOI: 10.1371/journal.pone.0277576
Availability: https://doi.org/10.1371/journal.pone.0277576
https://dx.plos.org/10.1371/journal.pone.0277576
Rights: http://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.80CEA39F
Database: BASE
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  – Url: https://doi.org/10.1371/journal.pone.0277576#
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  Data: Association between ustekinumab therapy and changes in specific anti-microbial response, serum biomarkers, and microbiota composition in patients with IBD: A pilot study
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  Data: <searchLink fieldCode="AR" term="%22Rob%2C+Filip%22">Rob, Filip</searchLink><br /><searchLink fieldCode="AR" term="%22Schierova%2C+Dagmar%22">Schierova, Dagmar</searchLink><br /><searchLink fieldCode="AR" term="%22Stehlikova%2C+Zuzana%22">Stehlikova, Zuzana</searchLink><br /><searchLink fieldCode="AR" term="%22Kreisinger%2C+Jakub%22">Kreisinger, Jakub</searchLink><br /><searchLink fieldCode="AR" term="%22Roubalova%2C+Radka%22">Roubalova, Radka</searchLink><br /><searchLink fieldCode="AR" term="%22Coufal%2C+Stepan%22">Coufal, Stepan</searchLink><br /><searchLink fieldCode="AR" term="%22Mihula%2C+Martin%22">Mihula, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Jackova%2C+Zuzana%22">Jackova, Zuzana</searchLink><br /><searchLink fieldCode="AR" term="%22Kverka%2C+Miloslav%22">Kverka, Miloslav</searchLink><br /><searchLink fieldCode="AR" term="%22Thon%2C+Tomas%22">Thon, Tomas</searchLink><br /><searchLink fieldCode="AR" term="%22Kostovcikova%2C+Klara%22">Kostovcikova, Klara</searchLink><br /><searchLink fieldCode="AR" term="%22Bajer%2C+Lukas%22">Bajer, Lukas</searchLink><br /><searchLink fieldCode="AR" term="%22Drastich%2C+Pavel%22">Drastich, Pavel</searchLink><br /><searchLink fieldCode="AR" term="%22Hercogova%2C+Jana+Tresnak%22">Hercogova, Jana Tresnak</searchLink><br /><searchLink fieldCode="AR" term="%22Novakova%2C+Michaela%22">Novakova, Michaela</searchLink><br /><searchLink fieldCode="AR" term="%22Kolar%2C+Martin%22">Kolar, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Vasatko%2C+Martin%22">Vasatko, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Lukas%2C+Milan%22">Lukas, Milan</searchLink><br /><searchLink fieldCode="AR" term="%22Tlaskalova-Hogenova%2C+Helena%22">Tlaskalova-Hogenova, Helena</searchLink><br /><searchLink fieldCode="AR" term="%22Jiraskova+Zakostelska%2C+Zuzana%22">Jiraskova Zakostelska, Zuzana</searchLink>
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  Data: Staley, Christopher<br />Ministerstvo Zdravotnictví Ceské Republiky<br />Mikrobiologický Ústav, Akademie Věd České Republiky
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  Data: PLOS ONE ; volume 17, issue 12, page e0277576 ; ISSN 1932-6203
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  Data: 2022
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  Data: PLOS Publications (via CrossRef)
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  Label: Description
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  Data: Background Ustekinumab, is a new therapy for patients with IBD, especially for patients suffering from Crohn’s disease (CD) who did not respond to anti-TNF treatment. To shed light on the longitudinal effect of ustekinumab on the immune system, we investigated the effect on skin and gut microbiota composition, specific immune response to commensals, and various serum biomarkers. Methodology/Principal findings We recruited 11 patients with IBD who were monitored over 40 weeks of ustekinumab therapy and 39 healthy controls (HC). We found differences in the concentrations of serum levels of osteoprotegerin, TGF-β1, IL-33, and serum IgM antibodies against Lactobacillus plantarum between patients with IBD and HC. The levels of these biomarkers did not change in response to ustekinumab treatment or with disease improvement during the 40 weeks of observation. Additionally, we identified differences in stool abundance of uncultured Subdoligranulum , Faecalibacterium , and Bacteroides between patients with IBD and HC. Conclusion/Significance In this preliminary study, we provide a unique overview of the longitudinal monitoring of fecal and skin microbial profiles as well as various serum biomarkers and humoral and cellular response to gut commensals in a small cohort of patients with IBD on ustekinumab therapy.
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  Data: 10.1371/journal.pone.0277576
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  Data: https://doi.org/10.1371/journal.pone.0277576<br />https://dx.plos.org/10.1371/journal.pone.0277576
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