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Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers

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Τίτλος: Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Συγγραφείς: Ilg, Winfried, Milne, Sarah, Schmitz-Hübsch, Tanja, Alcock, Lisa, Beichert, Lukas, Bertini, Enrico, Mohamed Ibrahim, Norlinah, Dawes, Helen, Gomez, Christopher M., Hanagasi, Hasmet, Kinnunen, Kirsi M., Minnerop, Martina, Németh, Andrea H., Newman, Jane, Ng, Yi Shiau, Rentz, Clara, Samanci, Bedia, Shah, Vrutangkumar V., Summa, Susanna, Vasco, Gessica, McNames, James, Horak, Fay B., on behalf of the Ataxia Global Initiative (AGI) working group Digital Motor Biomarkers
Πηγή: http://lobid.org/resources/99370676159206441#!, 23(4):1566-1592.
Έτος έκδοσης: 2023
Συλλογή: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Θεματικοί όροι: Ataxia/diagnosis [MeSH], Gait Disorders, Neurologic/diagnosis [MeSH], Humans [MeSH], Postural Balance/physiology [MeSH], Cerebellar Ataxia/diagnosis [MeSH], Neurologic/physiopathology [MeSH], Cerebellar Ataxia/drug therapy [MeSH], Digital motor performance marker, Cerebellar Ataxia/therapy [MeSH], Clinical Trials as Topic/standards [MeSH], Gait and posture, Cerebellar ataxia, Neurologic/therapy [MeSH], Clinical Trials as Topic/methods [MeSH], Gait Analysis/methods [MeSH], Gait/physiology [MeSH], Review, Cerebellar Ataxia/physiopathology [MeSH], Biomarkers [MeSH], Consensus [MeSH]
Περιγραφή: AbstractWith disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://repository.publisso.de/resource/frl:6499137; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269489/
DOI: 10.1007/s12311-023-01625-2
Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6499137
https://doi.org/10.1007/s12311-023-01625-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269489/
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.7F52644D
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
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PubType: Academic Journal
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  Data: Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
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  Data: <searchLink fieldCode="DE" term="%22Ataxia%2Fdiagnosis+[MeSH]%22">Ataxia/diagnosis [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Gait+Disorders%22">Gait Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic%2Fdiagnosis+[MeSH]%22">Neurologic/diagnosis [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Humans+[MeSH]%22">Humans [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Postural+Balance%2Fphysiology+[MeSH]%22">Postural Balance/physiology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+Ataxia%2Fdiagnosis+[MeSH]%22">Cerebellar Ataxia/diagnosis [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic%2Fphysiopathology+[MeSH]%22">Neurologic/physiopathology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+Ataxia%2Fdrug+therapy+[MeSH]%22">Cerebellar Ataxia/drug therapy [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Digital+motor+performance+marker%22">Digital motor performance marker</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+Ataxia%2Ftherapy+[MeSH]%22">Cerebellar Ataxia/therapy [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+Trials+as+Topic%2Fstandards+[MeSH]%22">Clinical Trials as Topic/standards [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Gait+and+posture%22">Gait and posture</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+ataxia%22">Cerebellar ataxia</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic%2Ftherapy+[MeSH]%22">Neurologic/therapy [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+Trials+as+Topic%2Fmethods+[MeSH]%22">Clinical Trials as Topic/methods [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Gait+Analysis%2Fmethods+[MeSH]%22">Gait Analysis/methods [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Gait%2Fphysiology+[MeSH]%22">Gait/physiology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Review%22">Review</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+Ataxia%2Fphysiopathology+[MeSH]%22">Cerebellar Ataxia/physiopathology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers+[MeSH]%22">Biomarkers [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Consensus+[MeSH]%22">Consensus [MeSH]</searchLink>
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  Data: <jats:title>Abstract</jats:title><jats:p>With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.</jats:p><jats:p>This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.</jats:p>
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