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Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis
Συγγραφείς: Riedl, Rebecca, Kühn, Annika, Hupfer, Yvonne, Hebecker, Betty, Peltner, Lukas K., Jordan, Paul M., Werz, Oliver, Lorkowski, Stefan, Wiegand, Cornelia, Wallert, Maria
Πηγή: http://lobid.org/resources/99370671252406441#!, 47(2):771-788.
Έτος έκδοσης: 2023
Συλλογή: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Θεματικοί όροι: Dermatitis, Atopic/chemically induced [MeSH], 2,4-dinitrochlorobenzene, Atopic/pathology [MeSH], Female [MeSH], Filaggrin Proteins [MeSH], Mice, Inbred BALB C [MeSH], Inflammation/chemically induced [MeSH], atopic dermatitis mouse model, Skin/drug effects [MeSH], sub-acute and chronic inflammation, Cytokines/metabolism [MeSH], Animals [MeSH], Skin/pathology [MeSH], Atopic/metabolism [MeSH], Mice [MeSH], Research, Dinitrochlorobenzene/toxicity [MeSH], Inflammation/metabolism [MeSH], Disease Models, Animal [MeSH], mild and moderate atopic dermatitis, Dexamethasone/pharmacology [MeSH], Skin/metabolism [MeSH]
Περιγραφή: AbstractThe mouse model of 2,4-dinitrochlorbenzene (DNCB)-induced human-like atopic dermatitis (hlAD) has been widely used to test novel treatment strategies and compounds. However, the study designs and methods are highly diverse, presenting different hlAD disease patterns that occur after sensitization and repeated challenge with DNCB on dorsal skin. In addition, there is a lack of information about the progression of the disease during the experiment and the achieved pheno- and endotypes, especially at the timepoint when therapeutic treatment is initiated. We here examine hlAD in a DNCB-induced BALB/cJRj model at different timepoints: (i) before starting treatment with dexamethasone, representing a standard drug control (day 12) and (ii) at the end of the experiment (day 22). Both timepoints display typical AD-associated characteristics: skin thickening, spongiosis, hyper- and parakeratosis, altered cytokine and gene expression, increased lipid mediator formation, barrier protein and antimicrobial peptide abnormalities, as well as lymphoid organ hypertrophy. Increased mast cell infiltration into the skin and elevated immunoglobulin E plasma concentrations indicate a type I allergy response. The DNCB-treated skin showed an extrinsic moderate sub-acute hlAD lesion at day 12 and an extrinsic mild sub-acute to chronic pheno- and endotype at day 22 with a dominating Th2 response. A dependency of the filaggrin formation and expression in correlation to the disease severity in the DNCB-treated skin was found. In conclusion, our study reveals a detailed classification of a hlAD at two timepoints with different inflammatory skin conditions and pheno- and endotypes, thereby providing a better understanding of the DNCB-induced hlAD model in BALB/cJRj mice.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://repository.publisso.de/resource/frl:6504113; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074229/
DOI: 10.1007/s10753-023-01943-x
Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6504113
https://doi.org/10.1007/s10753-023-01943-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074229/
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.7E2FABDF
Βάση Δεδομένων: BASE
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PubType: Academic Journal
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PreciseRelevancyScore: 929.480346679688
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis
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  Data: <searchLink fieldCode="AR" term="%22Riedl%2C+Rebecca%22">Riedl, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Kühn%2C+Annika%22">Kühn, Annika</searchLink><br /><searchLink fieldCode="AR" term="%22Hupfer%2C+Yvonne%22">Hupfer, Yvonne</searchLink><br /><searchLink fieldCode="AR" term="%22Hebecker%2C+Betty%22">Hebecker, Betty</searchLink><br /><searchLink fieldCode="AR" term="%22Peltner%2C+Lukas+K%2E%22">Peltner, Lukas K.</searchLink><br /><searchLink fieldCode="AR" term="%22Jordan%2C+Paul+M%2E%22">Jordan, Paul M.</searchLink><br /><searchLink fieldCode="AR" term="%22Werz%2C+Oliver%22">Werz, Oliver</searchLink><br /><searchLink fieldCode="AR" term="%22Lorkowski%2C+Stefan%22">Lorkowski, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Wiegand%2C+Cornelia%22">Wiegand, Cornelia</searchLink><br /><searchLink fieldCode="AR" term="%22Wallert%2C+Maria%22">Wallert, Maria</searchLink>
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  Data: <i>http://lobid.org/resources/99370671252406441#!, 47(2):771-788</i>.
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  Label: Publication Year
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  Data: 2023
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  Data: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Dermatitis%22">Dermatitis</searchLink><br /><searchLink fieldCode="DE" term="%22Atopic%2Fchemically+induced+[MeSH]%22">Atopic/chemically induced [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%222%2C4-dinitrochlorobenzene%22">2,4-dinitrochlorobenzene</searchLink><br /><searchLink fieldCode="DE" term="%22Atopic%2Fpathology+[MeSH]%22">Atopic/pathology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Female+[MeSH]%22">Female [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Filaggrin+Proteins+[MeSH]%22">Filaggrin Proteins [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Inbred+BALB+C+[MeSH]%22">Inbred BALB C [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%2Fchemically+induced+[MeSH]%22">Inflammation/chemically induced [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22atopic+dermatitis+mouse+model%22">atopic dermatitis mouse model</searchLink><br /><searchLink fieldCode="DE" term="%22Skin%2Fdrug+effects+[MeSH]%22">Skin/drug effects [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22sub-acute+and+chronic+inflammation%22">sub-acute and chronic inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%2Fmetabolism+[MeSH]%22">Cytokines/metabolism [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Animals+[MeSH]%22">Animals [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Skin%2Fpathology+[MeSH]%22">Skin/pathology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Atopic%2Fmetabolism+[MeSH]%22">Atopic/metabolism [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Mice+[MeSH]%22">Mice [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Dinitrochlorobenzene%2Ftoxicity+[MeSH]%22">Dinitrochlorobenzene/toxicity [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%2Fmetabolism+[MeSH]%22">Inflammation/metabolism [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+Models%22">Disease Models</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+[MeSH]%22">Animal [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22mild+and+moderate+atopic+dermatitis%22">mild and moderate atopic dermatitis</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone%2Fpharmacology+[MeSH]%22">Dexamethasone/pharmacology [MeSH]</searchLink><br /><searchLink fieldCode="DE" term="%22Skin%2Fmetabolism+[MeSH]%22">Skin/metabolism [MeSH]</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: <jats:title>Abstract</jats:title><jats:p>The mouse model of 2,4-dinitrochlorbenzene (DNCB)-induced human-like atopic dermatitis (hlAD) has been widely used to test novel treatment strategies and compounds. However, the study designs and methods are highly diverse, presenting different hlAD disease patterns that occur after sensitization and repeated challenge with DNCB on dorsal skin. In addition, there is a lack of information about the progression of the disease during the experiment and the achieved pheno- and endotypes, especially at the timepoint when therapeutic treatment is initiated. We here examine hlAD in a DNCB-induced BALB/cJRj model at different timepoints: (i) before starting treatment with dexamethasone, representing a standard drug control (day 12) and (ii) at the end of the experiment (day 22). Both timepoints display typical AD-associated characteristics: skin thickening, spongiosis, hyper- and parakeratosis, altered cytokine and gene expression, increased lipid mediator formation, barrier protein and antimicrobial peptide abnormalities, as well as lymphoid organ hypertrophy. Increased mast cell infiltration into the skin and elevated immunoglobulin E plasma concentrations indicate a type I allergy response. The DNCB-treated skin showed an extrinsic moderate sub-acute hlAD lesion at day 12 and an extrinsic mild sub-acute to chronic pheno- and endotype at day 22 with a dominating Th2 response. A dependency of the filaggrin formation and expression in correlation to the disease severity in the DNCB-treated skin was found. In conclusion, our study reveals a detailed classification of a hlAD at two timepoints with different inflammatory skin conditions and pheno- and endotypes, thereby providing a better understanding of the DNCB-induced hlAD model in BALB/cJRj mice.</jats:p>
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  Data: https://repository.publisso.de/resource/frl:6504113; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074229/
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  Data: 10.1007/s10753-023-01943-x
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  Data: https://repository.publisso.de/resource/frl:6504113<br />https://doi.org/10.1007/s10753-023-01943-x<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074229/
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        Value: 10.1007/s10753-023-01943-x
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        Type: general
      – SubjectFull: Atopic/chemically induced [MeSH]
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      – SubjectFull: 2,4-dinitrochlorobenzene
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        Type: general
      – SubjectFull: sub-acute and chronic inflammation
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      – SubjectFull: Dinitrochlorobenzene/toxicity [MeSH]
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              Y: 2023
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