Academic Journal
Systemic inflammation increases shear stress‐induced platelet plug formation measured by the PFA‐100
| Τίτλος: | Systemic inflammation increases shear stress‐induced platelet plug formation measured by the PFA‐100 |
|---|---|
| Συγγραφείς: | Homoncik, Monika, Blann, Andrew D., Hollenstein, Ursula, Pernerstorfer, Thomas, Eichler, Hans‐Georg, Jilma, Bernd |
| Πηγή: | British Journal of Haematology ; volume 111, issue 4, page 1250-1252 ; ISSN 0007-1048 1365-2141 |
| Στοιχεία εκδότη: | Wiley |
| Έτος έκδοσης: | 2000 |
| Συλλογή: | Wiley Online Library (Open Access Articles via Crossref) |
| Περιγραφή: | The PFA‐100 measures platelet plug formation under shear stress and is strongly dependent on von Willebrand Factor (VWF) levels in plasma. We therefore hypothesized that elevated VWF levels, possibly as a result of acute inflammation, adversely influence PFA‐100 results. Healthy volunteers received either 2 ng/kg endotoxin or placebo in a randomized controlled trial. Four hours after endotoxin (but not placebo) infusion VWF levels increased by 85%, collagen epinephrine‐induced closure time (CT) decreased by 47% and collagen ADP‐CT decreased by 38% ( P < 0·0001) respectively. In conclusion, systemic inflammation has a major impact on the results obtained by PFA‐100 and may confound interpretation of platelet function. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1111/j.1365-2141.2000.02473.x |
| Διαθεσιμότητα: | https://doi.org/10.1111/j.1365-2141.2000.02473.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2141.2000.02473.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2141.2000.02473.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Αριθμός Καταχώρησης: | edsbas.7D18F7FD |
| Βάση Δεδομένων: | BASE |
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