Academic Journal
Functional connectivity and topology in patients with restless legs syndrome: a case–control resting-state functional magnetic resonance imaging study
| Title: | Functional connectivity and topology in patients with restless legs syndrome: a case–control resting-state functional magnetic resonance imaging study |
|---|---|
| Authors: | Tuovinen N., Stefani A., Mitterling T., Heidbreder A., Frauscher B., Gizewski E. R., Poewe W., Hogl B., Scherfler C. |
| Contributors: | Tuovinen, N., Stefani, A., Mitterling, T., Heidbreder, A., Frauscher, B., Gizewski, E. R., Poewe, W., Hogl, B., Scherfler, C. |
| Publication Year: | 2021 |
| Collection: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| Subject Terms: | brain connectivity, functional magnetic resonance imaging, restless legs syndrome, sleep wake disorders |
| Description: | Background and purpose: Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. Methods: Eighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polytherapy combined with dopaminergic medication, n = 10), and 82 individually age- and gender-matched healthy controls were studied with resting-state functional magnetic resonance imaging. Connectivity of 12 resting-state networks was investigated with independent component analysis, and network topology was studied with graph methods among 410 brain regions. Results: Patients with restless legs syndrome showed significantly higher connectivity within salience (p = 0.029), executive (p = 0.001), and cerebellar (p = 0.041) networks, as well as significantly lower (p < 0.05) cerebello-frontal communication compared to controls. In addition, they had a significantly higher (p < 0.05) clustering coefficient and local efficiency in motor and frontal regions; lower clustering coefficient in the central sulcus; and lower local efficiency in the central opercular cortex, temporal, parieto-occipital, cuneus, and occipital regions compared to controls. Untreated patients had significantly lower (p < 0.05) cerebello-parietal communication compared to healthy controls. Connectivity between the thalamus and frontal regions was significantly increased (p < 0.05) in patients on dopaminergic medication compared to untreated patients and controls. Conclusions: Networks with higher intranetwork connectivity (i.e., salience, executive, cerebellar) and lower cerebello-frontal connectivity in the restless legs syndrome patients, as well as lower cerebello-parietal connectivity in untreated patients, correspond to regions associated with attention, response inhibitory control, and processing of sensory information. Intact cerebello-parietal communication and increased thalamic connectivity to the prefrontal ... |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33032390; info:eu-repo/semantics/altIdentifier/wos/WOS:000585174900001; volume:28; issue:2; firstpage:448; lastpage:458; numberofpages:11; journal:EUROPEAN JOURNAL OF NEUROLOGY; https://hdl.handle.net/11564/850855 |
| DOI: | 10.1111/ene.14577 |
| Availability: | https://hdl.handle.net/11564/850855 https://doi.org/10.1111/ene.14577 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.7CF93830 |
| Database: | BASE |
Be the first to leave a comment!