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Apoptotic and Antibacterial Activities of Terminalia catappa Ethanolic Extract

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Τίτλος: Apoptotic and Antibacterial Activities of Terminalia catappa Ethanolic Extract
Συγγραφείς: Gorkem Dulger, Başaran Dülger, Ilker Kiliccioglu
Πηγή: Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Vol 14, Iss 1, Pp 1-9 (2026)
Στοιχεία εκδότη: Düzce University
Έτος έκδοσης: 2026
Συλλογή: Directory of Open Access Journals: DOAJ Articles
Θεματικοί όροι: terminalia catappa, prostate cancer, apoptosis, prostat kanseri, apoptozis, Technology, Engineering (General). Civil engineering (General), TA1-2040, Science, Science (General), Q1-390
Περιγραφή: Prostate cancer remains a significant contributor to morbidity and mortality rates in men due to resistance to conventional treatments. Natural products such as Terminalia catappa have emerged as promising candidates with their antiproliferative and proapoptotic activities. Ethanolic extract of T. catappa leaves were tested against PC-3 and LNCaP prostate cancer cells. Antiproliferative activity was investigated using the WST-1 assay. Caspase-3, -8, -9, Bcl-2, p53, and survivin expression were investigated by ELISA and Western blot methods. The antibacterial activity of the extract was tested by the well diffusion method. T. catappa extract inhibited prostate cancer cell proliferation in a concentration and duration dependent profile, with IC50 values of 49.54 µg/mL (24 h) and 30.41 µg/mL (48 h) in PC-3 cells and 61.53 µg/mL (24 h) and 43.64 µg/mL (48 h) in LNCaP cells. Microscopic analysis revealed apoptotic effects, while HUVECs maintained their viability and morphology. Caspase-3, -8, and -9 activities were significantly increased, indicating activation of apoptotic pathways. Western blotting revealed a strong increase in p53 and a decrease in Bcl-2 and survivin. Additionally, the extract was found to exhibit stronger antibacterial activity against Gram-positive strains. These findings highlight the dual anticancer and antibacterial potential of the T. catappa ethanol extract.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://dergipark.org.tr/en/download/article-file/5197363; https://doaj.org/toc/2148-2446; https://doaj.org/article/7b47c0394b924d5bb22ac1cb733e88b4
DOI: 10.29130/dubited.1774499
Διαθεσιμότητα: https://doi.org/10.29130/dubited.1774499
https://doaj.org/article/7b47c0394b924d5bb22ac1cb733e88b4
Αριθμός Καταχώρησης: edsbas.78B445F6
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.29130/dubited.1774499#
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  Data: Apoptotic and Antibacterial Activities of Terminalia catappa Ethanolic Extract
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  Data: <searchLink fieldCode="AR" term="%22Gorkem+Dulger%22">Gorkem Dulger</searchLink><br /><searchLink fieldCode="AR" term="%22Başaran+Dülger%22">Başaran Dülger</searchLink><br /><searchLink fieldCode="AR" term="%22Ilker+Kiliccioglu%22">Ilker Kiliccioglu</searchLink>
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  Data: Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Vol 14, Iss 1, Pp 1-9 (2026)
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  Data: Düzce University
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  Data: 2026
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  Data: Directory of Open Access Journals: DOAJ Articles
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  Data: <searchLink fieldCode="DE" term="%22terminalia+catappa%22">terminalia catappa</searchLink><br /><searchLink fieldCode="DE" term="%22prostate+cancer%22">prostate cancer</searchLink><br /><searchLink fieldCode="DE" term="%22apoptosis%22">apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22prostat+kanseri%22">prostat kanseri</searchLink><br /><searchLink fieldCode="DE" term="%22apoptozis%22">apoptozis</searchLink><br /><searchLink fieldCode="DE" term="%22Technology%22">Technology</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering+%28General%29%2E+Civil+engineering+%28General%29%22">Engineering (General). Civil engineering (General)</searchLink><br /><searchLink fieldCode="DE" term="%22TA1-2040%22">TA1-2040</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink><br /><searchLink fieldCode="DE" term="%22Science+%28General%29%22">Science (General)</searchLink><br /><searchLink fieldCode="DE" term="%22Q1-390%22">Q1-390</searchLink>
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  Data: Prostate cancer remains a significant contributor to morbidity and mortality rates in men due to resistance to conventional treatments. Natural products such as Terminalia catappa have emerged as promising candidates with their antiproliferative and proapoptotic activities. Ethanolic extract of T. catappa leaves were tested against PC-3 and LNCaP prostate cancer cells. Antiproliferative activity was investigated using the WST-1 assay. Caspase-3, -8, -9, Bcl-2, p53, and survivin expression were investigated by ELISA and Western blot methods. The antibacterial activity of the extract was tested by the well diffusion method. T. catappa extract inhibited prostate cancer cell proliferation in a concentration and duration dependent profile, with IC50 values of 49.54 µg/mL (24 h) and 30.41 µg/mL (48 h) in PC-3 cells and 61.53 µg/mL (24 h) and 43.64 µg/mL (48 h) in LNCaP cells. Microscopic analysis revealed apoptotic effects, while HUVECs maintained their viability and morphology. Caspase-3, -8, and -9 activities were significantly increased, indicating activation of apoptotic pathways. Western blotting revealed a strong increase in p53 and a decrease in Bcl-2 and survivin. Additionally, the extract was found to exhibit stronger antibacterial activity against Gram-positive strains. These findings highlight the dual anticancer and antibacterial potential of the T. catappa ethanol extract.
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  Data: https://dergipark.org.tr/en/download/article-file/5197363; https://doaj.org/toc/2148-2446; https://doaj.org/article/7b47c0394b924d5bb22ac1cb733e88b4
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      – SubjectFull: prostate cancer
        Type: general
      – SubjectFull: apoptosis
        Type: general
      – SubjectFull: prostat kanseri
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