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The Assessment and Outcomes of Crossmatching in Lung Transplantation in Korean Patients

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The Assessment and Outcomes of Crossmatching in Lung Transplantation in Korean Patients
Συνεισφορές: Ha Eun Kim, Young Ho Yang, Hyo Chae Paik, Su Jin Jeong, Song Yee Kim, Moo Suk Park, Jin Gu Lee, Kim, Song Yee
Στοιχεία εκδότη: 대한의학회(The Korean Academy of Medical Sciences)
Έτος έκδοσης: 2022
Θεματικοί όροι: Graft Rejection / diagnosis, Graft Survival, HLA Antigens, Histocompatibility Testing / methods, Humans, Isoantibodies, Kidney Transplantation, Lung Transplantation, Retrospective Studies, Allocation, Crossmatching, Histocompatibility
Περιγραφή: Background: In lung transplantation, human leukocyte antigen (HLA) compatibility is not included in the lung allocation score system or considered when placing donor allografts. However, HLA matching may affect the outcomes of lung transplantation. This study evaluated the current assessment status, prevalence, and effects of HLA crossmatching in lung transplantation in Korean patients using nationwide multicenter registry data. Methods: Two hundred and twenty patients who received lung transplantation at six tertiary hospitals in South Korea between March 2015 and December 2019 were retrospectively reviewed. Clinical data, including general demographic characteristics, primary diagnosis, and pretransplant status of the recipients and donors registered by the Korean Organ Transplant Registry, were retrospectively analyzed. Survival analysis was performed using the Kaplan-Meier method with log-rank tests. Results: Complement-dependent cytotoxic crossmatch (CDC-XM) was performed in 208 patients (94.5%) and flow cytometric crossmatch (flow-XM) was performed in 125 patients (56.8%). Among them, nine patients (4.1%) showed T cell- and/or B cell-positive crossmatches. The incidences of postoperative complications, including primary graft dysfunction, acute rejection, and chronic allograft dysfunction in positively crossmatched patients, were not significant compared with those in patients without mismatches. Moreover, Kaplan-Meier analyses showed poorer 1-year survival in patients with positive crossmatch according to CDC-XM (P < 0.001) and T lymphocyte XM (P = 0.002) than in patients without mismatches. Conclusion: Positive CDC and T lymphocyte crossmatching results should be considered in the allocation of donor lungs. If unavailable, the result should be considered for postoperative management in lung transplantation. ; open
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
ISSN: 35668687
Relation: JOURNAL OF KOREAN MEDICAL SCIENCE; J01517; https://ir.ymlib.yonsei.ac.kr/handle/22282913/191571; T202302357
DOI: 10.3346/jkms.2022.37.e177
Διαθεσιμότητα: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191571
https://doi.org/10.3346/jkms.2022.37.e177
Rights: CC BY-NC-ND 2.0 KR
Αριθμός Καταχώρησης: edsbas.73B44C86
Βάση Δεδομένων: BASE
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  – Url: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191571#
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  Data: The Assessment and Outcomes of Crossmatching in Lung Transplantation in Korean Patients
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  Data: Ha Eun Kim&lt;br /&gt;Young Ho Yang&lt;br /&gt;Hyo Chae Paik&lt;br /&gt;Su Jin Jeong&lt;br /&gt;Song Yee Kim&lt;br /&gt;Moo Suk Park&lt;br /&gt;Jin Gu Lee&lt;br /&gt;Kim, Song Yee
– Name: Publisher
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  Data: 대한의학회(The Korean Academy of Medical Sciences)
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2022
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Graft+Rejection+%2F+diagnosis%22&quot;&gt;Graft Rejection / diagnosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Graft+Survival%22&quot;&gt;Graft Survival&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HLA+Antigens%22&quot;&gt;HLA Antigens&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Histocompatibility+Testing+%2F+methods%22&quot;&gt;Histocompatibility Testing / methods&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Isoantibodies%22&quot;&gt;Isoantibodies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Kidney+Transplantation%22&quot;&gt;Kidney Transplantation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Lung+Transplantation%22&quot;&gt;Lung Transplantation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retrospective+Studies%22&quot;&gt;Retrospective Studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Allocation%22&quot;&gt;Allocation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Crossmatching%22&quot;&gt;Crossmatching&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Histocompatibility%22&quot;&gt;Histocompatibility&lt;/searchLink&gt;
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background: In lung transplantation, human leukocyte antigen (HLA) compatibility is not included in the lung allocation score system or considered when placing donor allografts. However, HLA matching may affect the outcomes of lung transplantation. This study evaluated the current assessment status, prevalence, and effects of HLA crossmatching in lung transplantation in Korean patients using nationwide multicenter registry data. Methods: Two hundred and twenty patients who received lung transplantation at six tertiary hospitals in South Korea between March 2015 and December 2019 were retrospectively reviewed. Clinical data, including general demographic characteristics, primary diagnosis, and pretransplant status of the recipients and donors registered by the Korean Organ Transplant Registry, were retrospectively analyzed. Survival analysis was performed using the Kaplan-Meier method with log-rank tests. Results: Complement-dependent cytotoxic crossmatch (CDC-XM) was performed in 208 patients (94.5%) and flow cytometric crossmatch (flow-XM) was performed in 125 patients (56.8%). Among them, nine patients (4.1%) showed T cell- and/or B cell-positive crossmatches. The incidences of postoperative complications, including primary graft dysfunction, acute rejection, and chronic allograft dysfunction in positively crossmatched patients, were not significant compared with those in patients without mismatches. Moreover, Kaplan-Meier analyses showed poorer 1-year survival in patients with positive crossmatch according to CDC-XM (P &lt; 0.001) and T lymphocyte XM (P = 0.002) than in patients without mismatches. Conclusion: Positive CDC and T lymphocyte crossmatching results should be considered in the allocation of donor lungs. If unavailable, the result should be considered for postoperative management in lung transplantation. ; open
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  Data: JOURNAL OF KOREAN MEDICAL SCIENCE; J01517; https://ir.ymlib.yonsei.ac.kr/handle/22282913/191571; T202302357
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3346/jkms.2022.37.e177
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  Data: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191571&lt;br /&gt;https://doi.org/10.3346/jkms.2022.37.e177
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  Data: CC BY-NC-ND 2.0 KR
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  Data: edsbas.73B44C86
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3346/jkms.2022.37.e177
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Graft Rejection / diagnosis
        Type: general
      – SubjectFull: Graft Survival
        Type: general
      – SubjectFull: HLA Antigens
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      – SubjectFull: Isoantibodies
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      – SubjectFull: Kidney Transplantation
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      – SubjectFull: Lung Transplantation
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      – SubjectFull: Allocation
        Type: general
      – SubjectFull: Crossmatching
        Type: general
      – SubjectFull: Histocompatibility
        Type: general
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      – TitleFull: The Assessment and Outcomes of Crossmatching in Lung Transplantation in Korean Patients
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