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Radioiodination, biodistribution and pharmacokinetics of berberine in mice

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Radioiodination, biodistribution and pharmacokinetics of berberine in mice
Συγγραφείς: Li, ZJ, Wei, Y, Chu, TW, Wang, XY, Liu, XQ, Wang, Y, Hu, SW
Συνεισφορές: Li, ZJ (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.
Πηγή: SCI
Στοιχεία εκδότη: journal of radioanalytical and nuclear chemistry
Έτος έκδοσης: 2005
Συλλογή: Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
Θεματικοί όροι: IODINATION, PANCREAS
Περιγραφή: Berberine was iodized by iodine monochloride, followed by an isotopic exchange reaction with (NaI)-I-125. The radiochemical purity and in vitro and in vivo stability were quite satisfactory. The biodistribution in mice showed that the concentration of I-125-labeled berberine was high in the gallbladder and gastrointestinal system, as compared to other organs. Berberine was metabolized in the liver, partly excreted through the hepatobiliary tract, and underwent a process of hepatoenteral circulation. Its main route of elimination was renal excretion. Blood concentration-time curve was fitted with an open two-compartment model. The plasma protein binding rate was(48 +/- 3.8)%. The results indicated that the radioiodinated berberine has similar in vivo behavior and pharmacokinetics to berberine reported before. The novel radioiodination is a convenient method to study in vivo behavior of such alkaloids. ; Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; SCI(E) ; 7 ; ARTICLE ; 3 ; 355-359 ; 265
Τύπος εγγράφου: journal/newspaper
Γλώσσα: English
Relation: 988732; https://hdl.handle.net/20.500.11897/151585; WOS:000231307200002
DOI: 10.1007/s10967-005-0832-4
Διαθεσιμότητα: https://hdl.handle.net/20.500.11897/151585
https://doi.org/10.1007/s10967-005-0832-4
Αριθμός Καταχώρησης: edsbas.72988521
Βάση Δεδομένων: BASE
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  Data: Radioiodination, biodistribution and pharmacokinetics of berberine in mice
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  Data: Li, ZJ (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.<br />Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China.
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  Data: Berberine was iodized by iodine monochloride, followed by an isotopic exchange reaction with (NaI)-I-125. The radiochemical purity and in vitro and in vivo stability were quite satisfactory. The biodistribution in mice showed that the concentration of I-125-labeled berberine was high in the gallbladder and gastrointestinal system, as compared to other organs. Berberine was metabolized in the liver, partly excreted through the hepatobiliary tract, and underwent a process of hepatoenteral circulation. Its main route of elimination was renal excretion. Blood concentration-time curve was fitted with an open two-compartment model. The plasma protein binding rate was(48 +/- 3.8)%. The results indicated that the radioiodinated berberine has similar in vivo behavior and pharmacokinetics to berberine reported before. The novel radioiodination is a convenient method to study in vivo behavior of such alkaloids. ; Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; SCI(E) ; 7 ; ARTICLE ; 3 ; 355-359 ; 265
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