Academic Journal
Radioiodination, biodistribution and pharmacokinetics of berberine in mice
| Τίτλος: | Radioiodination, biodistribution and pharmacokinetics of berberine in mice |
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| Συγγραφείς: | Li, ZJ, Wei, Y, Chu, TW, Wang, XY, Liu, XQ, Wang, Y, Hu, SW |
| Συνεισφορές: | Li, ZJ (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China. |
| Πηγή: | SCI |
| Στοιχεία εκδότη: | journal of radioanalytical and nuclear chemistry |
| Έτος έκδοσης: | 2005 |
| Συλλογή: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Θεματικοί όροι: | IODINATION, PANCREAS |
| Περιγραφή: | Berberine was iodized by iodine monochloride, followed by an isotopic exchange reaction with (NaI)-I-125. The radiochemical purity and in vitro and in vivo stability were quite satisfactory. The biodistribution in mice showed that the concentration of I-125-labeled berberine was high in the gallbladder and gastrointestinal system, as compared to other organs. Berberine was metabolized in the liver, partly excreted through the hepatobiliary tract, and underwent a process of hepatoenteral circulation. Its main route of elimination was renal excretion. Blood concentration-time curve was fitted with an open two-compartment model. The plasma protein binding rate was(48 +/- 3.8)%. The results indicated that the radioiodinated berberine has similar in vivo behavior and pharmacokinetics to berberine reported before. The novel radioiodination is a convenient method to study in vivo behavior of such alkaloids. ; Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; SCI(E) ; 7 ; ARTICLE ; 3 ; 355-359 ; 265 |
| Τύπος εγγράφου: | journal/newspaper |
| Γλώσσα: | English |
| Relation: | 988732; https://hdl.handle.net/20.500.11897/151585; WOS:000231307200002 |
| DOI: | 10.1007/s10967-005-0832-4 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11897/151585 https://doi.org/10.1007/s10967-005-0832-4 |
| Αριθμός Καταχώρησης: | edsbas.72988521 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1007/s10967-005-0832-4 |
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