Dissertation/Thesis
Προβολή σε EDS

Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex
Συγγραφείς: Riccardo Pirone, Irene Gorrino, Anna Vedani, Carlotta Maiocchi, Giulia Mattavelli
Πηγή: Biomedicines ; Volume 14 ; Issue 3 ; Pages: 519
Στοιχεία εκδότη: Multidisciplinary Digital Publishing Institute
Έτος έκδοσης: 2026
Συλλογή: MDPI Open Access Publishing
Θεματικοί όροι: HD-tDCS, interoception, cognitive impulsivity, insula, cingulate cortex, interoceptive-cognitive integration
Περιγραφή: Background: Interoception has been proposed as a key mechanism underlying impulsive behaviours, including maladaptive eating. However, the brain mechanisms supporting the interaction between interoception and impulsivity across different reward types remain unclear. This study investigated whether modulating the right insula and the dorsal anterior cingulate cortex (dACC) using high-definition transcranial direct current stimulation (HD-tDCS) could affect interoceptive accuracy and impulsive decision-making. Methods: Model-based HD-tDCS montages were defined to target the right insula and dACC. Two behavioural paradigms were administered: (i) the heartbeat detection task (HBD) to assess interoceptive accuracy and (ii) two versions of the delay discounting (DD) task with food and monetary rewards to measure impulsivity. Heart rate variability (HRV) was recorded as an index of autonomic activity. HD-tDCS was delivered online during the HBD, while DD tasks were completed offline. Twenty-four participants took part in four sessions in a within-subject design: baseline DD tasks, anodal HD-tDCS targeting the insula, dACC, or sham stimulation. Results: Stimulation of both the insula and dACC reduced participants’ ability to detect synchronous heartbeat while improving accuracy in exteroceptive trials. Discounting rates significantly increased following insula stimulation. Moreover, HD-tDCS effects on DD performance varied depending on reward type. Conclusions: These findings suggest differential contributions of the dACC and insula in interoceptive and exteroceptive processing and support the effect of HD-tDCS combined with interoceptive tasks to modulate impulsive decision-making. Reward-specific effects highlight the importance of stimulus type when designing interventions for impulsive eating behaviours.
Τύπος εγγράφου: Thesis
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Relation: Molecular and Translational Medicine; https://dx.doi.org/10.3390/biomedicines14030519
DOI: 10.3390/biomedicines14030519
Διαθεσιμότητα: https://doi.org/10.3390/biomedicines14030519
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.708896BB
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.3390/biomedicines14030519#
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  Data: Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex
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  Data: <searchLink fieldCode="AR" term="%22Riccardo+Pirone%22">Riccardo Pirone</searchLink><br /><searchLink fieldCode="AR" term="%22Irene+Gorrino%22">Irene Gorrino</searchLink><br /><searchLink fieldCode="AR" term="%22Anna+Vedani%22">Anna Vedani</searchLink><br /><searchLink fieldCode="AR" term="%22Carlotta+Maiocchi%22">Carlotta Maiocchi</searchLink><br /><searchLink fieldCode="AR" term="%22Giulia+Mattavelli%22">Giulia Mattavelli</searchLink>
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  Data: Biomedicines ; Volume 14 ; Issue 3 ; Pages: 519
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  Data: Multidisciplinary Digital Publishing Institute
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  Data: 2026
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  Data: MDPI Open Access Publishing
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  Data: <searchLink fieldCode="DE" term="%22HD-tDCS%22">HD-tDCS</searchLink><br /><searchLink fieldCode="DE" term="%22interoception%22">interoception</searchLink><br /><searchLink fieldCode="DE" term="%22cognitive+impulsivity%22">cognitive impulsivity</searchLink><br /><searchLink fieldCode="DE" term="%22insula%22">insula</searchLink><br /><searchLink fieldCode="DE" term="%22cingulate+cortex%22">cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22interoceptive-cognitive+integration%22">interoceptive-cognitive integration</searchLink>
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  Label: Description
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  Data: Background: Interoception has been proposed as a key mechanism underlying impulsive behaviours, including maladaptive eating. However, the brain mechanisms supporting the interaction between interoception and impulsivity across different reward types remain unclear. This study investigated whether modulating the right insula and the dorsal anterior cingulate cortex (dACC) using high-definition transcranial direct current stimulation (HD-tDCS) could affect interoceptive accuracy and impulsive decision-making. Methods: Model-based HD-tDCS montages were defined to target the right insula and dACC. Two behavioural paradigms were administered: (i) the heartbeat detection task (HBD) to assess interoceptive accuracy and (ii) two versions of the delay discounting (DD) task with food and monetary rewards to measure impulsivity. Heart rate variability (HRV) was recorded as an index of autonomic activity. HD-tDCS was delivered online during the HBD, while DD tasks were completed offline. Twenty-four participants took part in four sessions in a within-subject design: baseline DD tasks, anodal HD-tDCS targeting the insula, dACC, or sham stimulation. Results: Stimulation of both the insula and dACC reduced participants’ ability to detect synchronous heartbeat while improving accuracy in exteroceptive trials. Discounting rates significantly increased following insula stimulation. Moreover, HD-tDCS effects on DD performance varied depending on reward type. Conclusions: These findings suggest differential contributions of the dACC and insula in interoceptive and exteroceptive processing and support the effect of HD-tDCS combined with interoceptive tasks to modulate impulsive decision-making. Reward-specific effects highlight the importance of stimulus type when designing interventions for impulsive eating behaviours.
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      – SubjectFull: cognitive impulsivity
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      – SubjectFull: insula
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      – SubjectFull: cingulate cortex
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      – SubjectFull: interoceptive-cognitive integration
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      – TitleFull: Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex
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