Academic Journal
Vitamin D levels and perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan
| Τίτλος: | Vitamin D levels and perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan |
|---|---|
| Συγγραφείς: | Etyemez, S., Mehta, K., Faiz, J., Ahmad, M., Zaidi, A., Atif, N., Rahman, A., Malik, A., Voegtline, K.M., Surkan, P.J., Osborne, L.M. |
| Στοιχεία εκδότη: | Springer |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Cornell University: eCommons@Cornell |
| Θεματικοί όροι: | WCM Library Coordinated Deposit, Humans, Female, Pakistan/epidemiology, Vitamin D/blood/analogs & derivatives, Vitamin D Deficiency/blood/epidemiology/psychology/complications, Adult, Pregnancy, Anxiety/blood/therapy/psychology, Cognitive Behavioral Therapy/methods, Cytokines/blood, Biomarkers/blood, Postpartum Period, Pregnancy Complications/psychology/blood/therapy, Immune markers, Maternal health, Perinatal anxiety, Vitamin D deficiency |
| Περιγραφή: | PURPOSE: This study investigates Vitamin D levels across the perinatal period and relationships with perinatal anxiety and immune markers in women in Pakistan. METHODS: We analyzed plasma levels of 25-hydroxyvitamin D and cytokines and chemokines from 117 participants from the "Happy Mother-Healthy Baby" trial, which evaluated a non-specialist delivered cognitive behavioral therapy intervention for perinatal anxiety. Blood samples were collected at four timepoints: T1 (10-22 weeks), T2 (22-26 weeks), T3 (34-38 weeks), and T4 (six weeks postpartum). Participants were categorized into anxiety groups using K-means clustering. Mixed-effect models were used to examine Vitamin D trajectories, and moderation analysis explored the impact of immune markers on the Vitamin D-anxiety relationship. RESULTS: Vitamin D levels were severely deficient across all timepoints (< 5 ng/ml) and declined significantly from T1 to T2 (Œ≤ = -0.549, p = .006) before rebounding postpartum (Œ≤ = 1.492, p < .0001). Despite this widespread Vitamin D deficiency, no significant differences in Vitamin D trajectories were observed across anxiety groups. Higher innate immune activity correlated with higher Vitamin D levels at T1. IL-6 and CXCL-8 levels moderated the Vitamin D and anxiety relationship at T2 (IL-6: Œ≤ = 2.98, p = .015; CXCL-8: Œ≤ = 0.72, p = .030); among those with higher levels of IL-6 and CXCL-8, higher Vitamin D levels were associated with higher levels of anxiety. CONCLUSIONS: These findings indicate the need for further research on maternal Vitamin D deficiency and its relationship with immune function in low- and middle-income countries. ; 2027-01-07 |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | Archives of women's mental health; https://doi.org/10.1007/s00737-025-01653-3; https://hdl.handle.net/1813/124355 |
| Διαθεσιμότητα: | https://hdl.handle.net/1813/124355 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.6F5DB55C |
| Βάση Δεδομένων: | BASE |
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