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Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls

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Τίτλος: Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls
Συγγραφείς: Gould, AAM, Walsh, NP, Tipton, MJ, Zurawlew, MJ, Tayari, O, House, C, Delves, SK, Robson, SC, Shute, JJ, Watts, JEM, Roberts, AJ, Rawcliffe, AJ, Robinson, MR, Corbett, J
Στοιχεία εκδότη: Wiley
Έτος έκδοσης: 2025
Συλλογή: Liverpool John Moores University: LJMU Research Online
Θεματικοί όροι: RC1200 Sports Medicine
Περιγραφή: The gastrointestinal (GI) microbiota and GI barrier integrity are hypothesised to contribute to exertional heat illness (EHI) aetiology. We compared the faecal microbiome, GI barrier integrity, inflammation and thermoregulation of 29 recent (∼4 months) EHI patients (a group with elevated EHI risk) and 29 control individuals without prior EHI history, matched for variables influencing thermoregulation and GI microbiota. Participants completed an exercise heat tolerance assessment (HTA), with faecal microbiome assessed by 16S rRNA gene amplicon sequencing of stool samples and blood biomarkers of GI barrier integrity and inflammation measured pre‐ and post‐HTA. With the exception of the Simpson index (patient = 0.97 ± 0.01 vs. control = 0.98 ± 0.00, P = 0.030), there were no between‐groups differences in faecal microbiome composition (α‐diversity, β‐diversity, relative abundance, differential abundance), GI barrier integrity, inflammation or terminal thermoregulatory indices. Individuals were subsequently classified as heat tolerant (n = 46) or intolerant (n = 12) on the basis of the HTA. Heat intolerant individuals demonstrated lower sudomotor response (intolerant = 0.53 (0.17) vs. tolerant = 0.62 (0.20) L m−2 h−1, P = 0.011) despite greater thermoregulatory strain (e.g., terminal Trec: intolerant = 39.20 ± 0.31 vs. tolerant = 38.80 ± 0.31°C, P < 0.001), lower Firmicutes:Bacteroidota ratio (intolerant = 3.7 (0.6) vs. tolerant = 4.5 (2.0), P = 0.019) and higher plasma [sCD14] (P = 0.014), but other aspects of faecal microbiome, GI integrity or inflammation did not differ from heat tolerant individuals. In ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: text
Γλώσσα: English
ISSN: 0958-0670
Relation: https://researchonline.ljmu.ac.uk/id/eprint/26674/1/Faecal%20microbiome%20gastrointestinal%20integrity%20inflammation%20and%20thermoregulation.pdf; Gould, AAM, Walsh, NP, Tipton, MJ, Zurawlew, MJ ORCID logoorcid:0000-0003-3608-1028 , Tayari, O, House, C, Delves, SK, Robson, SC, Shute, JJ, Watts, JEM, Roberts, AJ, Rawcliffe, AJ, Robinson, MR and Corbett, J ORCID logoorcid:0000-0002-6552-6471 (2025) Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls. Experimental Physiology. ISSN 0958-0670
DOI: 10.1113/ep092849
Διαθεσιμότητα: https://researchonline.ljmu.ac.uk/id/eprint/26674/
https://researchonline.ljmu.ac.uk/id/eprint/26674/1/Faecal%20microbiome%20gastrointestinal%20integrity%20inflammation%20and%20thermoregulation.pdf
https://doi.org/10.1113/ep092849
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  Data: Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gould%2C+AAM%22&quot;&gt;Gould, AAM&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Walsh%2C+NP%22&quot;&gt;Walsh, NP&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tipton%2C+MJ%22&quot;&gt;Tipton, MJ&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zurawlew%2C+MJ%22&quot;&gt;Zurawlew, MJ&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tayari%2C+O%22&quot;&gt;Tayari, O&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22House%2C+C%22&quot;&gt;House, C&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Delves%2C+SK%22&quot;&gt;Delves, SK&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Robson%2C+SC%22&quot;&gt;Robson, SC&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shute%2C+JJ%22&quot;&gt;Shute, JJ&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Watts%2C+JEM%22&quot;&gt;Watts, JEM&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Roberts%2C+AJ%22&quot;&gt;Roberts, AJ&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rawcliffe%2C+AJ%22&quot;&gt;Rawcliffe, AJ&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Robinson%2C+MR%22&quot;&gt;Robinson, MR&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Corbett%2C+J%22&quot;&gt;Corbett, J&lt;/searchLink&gt;
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  Data: The gastrointestinal (GI) microbiota and GI barrier integrity are hypothesised to contribute to exertional heat illness (EHI) aetiology. We compared the faecal microbiome, GI barrier integrity, inflammation and thermoregulation of 29 recent (∼4 months) EHI patients (a group with elevated EHI risk) and 29 control individuals without prior EHI history, matched for variables influencing thermoregulation and GI microbiota. Participants completed an exercise heat tolerance assessment (HTA), with faecal microbiome assessed by 16S rRNA gene amplicon sequencing of stool samples and blood biomarkers of GI barrier integrity and inflammation measured pre‐ and post‐HTA. With the exception of the Simpson index (patient = 0.97 &#177; 0.01 vs. control = 0.98 &#177; 0.00, &lt;jats:italic&gt;P &lt;/jats:italic&gt;= 0.030), there were no between‐groups differences in faecal microbiome composition (α‐diversity, β‐diversity, relative abundance, differential abundance), GI barrier integrity, inflammation or terminal thermoregulatory indices. Individuals were subsequently classified as heat tolerant (&lt;jats:italic&gt;n &lt;/jats:italic&gt;= 46) or intolerant (&lt;jats:italic&gt;n &lt;/jats:italic&gt;= 12) on the basis of the HTA. Heat intolerant individuals demonstrated lower sudomotor response (intolerant = 0.53 (0.17) vs. tolerant = 0.62 (0.20) L m&lt;jats:sup&gt;−2&lt;/jats:sup&gt; h&lt;jats:sup&gt;−1&lt;/jats:sup&gt;, &lt;jats:italic&gt;P &lt;/jats:italic&gt;= 0.011) despite greater thermoregulatory strain (e.g., terminal &lt;jats:italic&gt;T&lt;/jats:italic&gt;&lt;jats:sub&gt;rec&lt;/jats:sub&gt;: intolerant = 39.20 &#177; 0.31 vs. tolerant = 38.80 &#177; 0.31&#176;C, &lt;jats:italic&gt;P &lt;/jats:italic&gt;&lt; 0.001), lower Firmicutes:Bacteroidota ratio (intolerant = 3.7 (0.6) vs. tolerant = 4.5 (2.0), &lt;jats:italic&gt;P &lt;/jats:italic&gt;= 0.019) and higher plasma [sCD14] (&lt;jats:italic&gt;P &lt;/jats:italic&gt;= 0.014), but other aspects of faecal microbiome, GI integrity or inflammation did not differ from heat tolerant individuals. In ...
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  Data: https://researchonline.ljmu.ac.uk/id/eprint/26674/1/Faecal%20microbiome%20gastrointestinal%20integrity%20inflammation%20and%20thermoregulation.pdf; Gould, AAM, Walsh, NP, Tipton, MJ, Zurawlew, MJ ORCID logoorcid:0000-0003-3608-1028 , Tayari, O, House, C, Delves, SK, Robson, SC, Shute, JJ, Watts, JEM, Roberts, AJ, Rawcliffe, AJ, Robinson, MR and Corbett, J ORCID logoorcid:0000-0002-6552-6471 (2025) Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls. Experimental Physiology. ISSN 0958-0670
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