Academic Journal
Προβολή σε EDS

αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission
Συγγραφείς: Perciani, CT, Jaoko, W, Farah, B, Ostrowski, MA, Anzala, O, MacDonald, KS, KAVI-ICR Team.
Στοιχεία εκδότη: University of Nairobi
Έτος έκδοσης: 2018
Συλλογή: University of Nairobi Digital Repository
Περιγραφή: Cell surface expression of α4β7, α4β1 and αEβ7 integrins play a key role in T cell distribution. Understanding the contribution of integrins to the density and ratios of CD4+: CD4negT cell at the portals of entry for HIV is of fundamental importance for the advance of more effective HIV prevention strategies. We therefore set out to characterize and compare the expression of α4β7, α4β1 and αEβ7 integrins on systemic, cervical and rectal CD4+ and CD4negT cells isolated from a cohort of healthy Kenyan women at low risk for sexually transmitted infections (STI) (n = 45). Here we show that blood and cervix were enriched in α4+β1+CD4+T cells and α4+β7hiCD4+T cells, whereas the rectum had an equal frequency of α4+β7hiCD4+T cells and αE+β7hiCD4+T cells. Most cervical and rectal αE+β7hiCD4+T cells expressed CCR5 as well as CD69. Interestingly, αEβ7 was the predominant integrin expressed by CD4negT cells in both mucosal sites, outnumbering αE+β7hiCD4+T cells approximately 2-fold in the cervix and 7-fold in the rectum. The majority of αE+β7hiCD4negT cells expressed CD69 at the mucosa. Taken together, our results show unique tissue-specific patterns of integrin expression. These results can help in guiding vaccine design and also the use of therapeutically targeting integrin adhesion as a means to preventing HIV.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/octet-stream
Γλώσσα: English
Relation: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192482; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192482&type=printable; https://hdl.handle.net/11295/103412
DOI: 10.1371/journal.pone.0192482
DOI: 10.1371/journal.pone.0192482&type=printable
Διαθεσιμότητα: https://hdl.handle.net/11295/103412
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192482
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192482&type=printable
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Αριθμός Καταχώρησης: edsbas.6C44ABA5
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://hdl.handle.net/11295/103412#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.6C44ABA5
RelevancyScore: 872
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 872.436645507813
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Perciani%2C+CT%22">Perciani, CT</searchLink><br /><searchLink fieldCode="AR" term="%22Jaoko%2C+W%22">Jaoko, W</searchLink><br /><searchLink fieldCode="AR" term="%22Farah%2C+B%22">Farah, B</searchLink><br /><searchLink fieldCode="AR" term="%22Ostrowski%2C+MA%22">Ostrowski, MA</searchLink><br /><searchLink fieldCode="AR" term="%22Anzala%2C+O%22">Anzala, O</searchLink><br /><searchLink fieldCode="AR" term="%22MacDonald%2C+KS%22">MacDonald, KS</searchLink><br /><searchLink fieldCode="AR" term="%22KAVI-ICR+Team%2E%22">KAVI-ICR Team.</searchLink>
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: University of Nairobi
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2018
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: University of Nairobi Digital Repository
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Cell surface expression of α4β7, α4β1 and αEβ7 integrins play a key role in T cell distribution. Understanding the contribution of integrins to the density and ratios of CD4+: CD4negT cell at the portals of entry for HIV is of fundamental importance for the advance of more effective HIV prevention strategies. We therefore set out to characterize and compare the expression of α4β7, α4β1 and αEβ7 integrins on systemic, cervical and rectal CD4+ and CD4negT cells isolated from a cohort of healthy Kenyan women at low risk for sexually transmitted infections (STI) (n = 45). Here we show that blood and cervix were enriched in α4+β1+CD4+T cells and α4+β7hiCD4+T cells, whereas the rectum had an equal frequency of α4+β7hiCD4+T cells and αE+β7hiCD4+T cells. Most cervical and rectal αE+β7hiCD4+T cells expressed CCR5 as well as CD69. Interestingly, αEβ7 was the predominant integrin expressed by CD4negT cells in both mucosal sites, outnumbering αE+β7hiCD4+T cells approximately 2-fold in the cervix and 7-fold in the rectum. The majority of αE+β7hiCD4negT cells expressed CD69 at the mucosa. Taken together, our results show unique tissue-specific patterns of integrin expression. These results can help in guiding vaccine design and also the use of therapeutically targeting integrin adhesion as a means to preventing HIV.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: application/octet-stream
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192482; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192482&type=printable; https://hdl.handle.net/11295/103412
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1371/journal.pone.0192482
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1371/journal.pone.0192482&type=printable
– Name: URL
  Label: Availability
  Group: URL
  Data: https://hdl.handle.net/11295/103412<br />http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192482<br />http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192482&type=printable
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.6C44ABA5
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.6C44ABA5
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1371/journal.pone.0192482
    Languages:
      – Text: English
    Titles:
      – TitleFull: αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Perciani, CT
      – PersonEntity:
          Name:
            NameFull: Jaoko, W
      – PersonEntity:
          Name:
            NameFull: Farah, B
      – PersonEntity:
          Name:
            NameFull: Ostrowski, MA
      – PersonEntity:
          Name:
            NameFull: Anzala, O
      – PersonEntity:
          Name:
            NameFull: MacDonald, KS
      – PersonEntity:
          Name:
            NameFull: KAVI-ICR Team.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1