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Nur77 Is Associated With Polyfunctional Properties in Virus‐Specific Human CD8 + T Cells

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Title: Nur77 Is Associated With Polyfunctional Properties in Virus‐Specific Human CD8 + T Cells
Authors: Martel, Fabiola, Rincón, Daniel, Passaes, Caroline, Arévalo, Leonardo, Torres, Marcela, Ramirez, Natalia, Narváez, Carlos, Toro, Jessica, Sussmann, Otto, Franco, Manuel, Mateus, José, Sidney, John, Sette, Alessandro, Sáez-Cirión, Asier, Perdomo-Celis, Federico
Contributors: Pontificia Universidad Javeriana Bogotá, Colombia (PUJ), CellRep (Entreprise), Réservoirs viraux et contrôle immunitaire / Viral reservoirs and immune control, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences, Department of Infectious Diseases, Infectoclinicos IPS, Bogotá, Colombia., Universidad Surcolombiana - Université colombienne du sud - South Colombian University (USCO), Clínica Medilaser - Neiva Huila, Colombia (CM), La Jolla Institute for Immunology La Jolla, CA, États-Unis, Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R03AI180633 (to F.P.-C.), as well as Vicerrectoría de Investigación, Pontificia Universidad Javeriana (Grant number 20824, to F.P.-C.). F.M. was partially supported by a scholarship from Pontificia Universidad Javeriana.
Source: ISSN: 0014-2980.
Publisher Information: CCSD
Wiley-VCH Verlag
Publication Year: 2026
Subject Terms: CD8+ T cells, Nur77, human, memory, polyfunctionality, proliferation, stem‐like, [SDV]Life Sciences [q-bio]
Description: International audience ; Human CD8 + T cells undergo significant metabolic and transcriptional shifts during activation and differentiation. The orphan nuclear receptor Nur77 plays a role in modulating these processes and has been linked to T cell dysfunction. However, few studies have addressed its role in the memory potential and functionality of human CD8 + T cells. Here, we evaluated the expression of Nur77 in human CD8 + T cells, focusing on its relationship with their differentiation profile and functionality. Our findings indicate that Nur77 is associated with an early‐differentiated, T cell factor 1 + (TCF‐1 + ) memory‐like phenotype in both total and virus‐specific human CD8 + T cells across contexts of acute resolved or chronic viral infection and vaccination. Nur77 expression was associated with cytokine polyfunctionality and increased proliferative capacity in long‐lived antigen‐responsive cells. Moreover, the modulation of Nur77 activity in vitro enhanced the functionality of chronic human immunodeficiency virus (HIV) and hepatitis B virus (HBV)‐specific CD8 + T cells. These results suggest that Nur77 is associated with polyfunctional properties in virus‐specific CD8 + T cell responses in humans. In addition, this study provides insights into novel strategies for enhancing CD8 + T cell functionality in settings of chronic antigen stimulation.
Document Type: article in journal/newspaper
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/42117214; PUBMED: 42117214; PUBMEDCENTRAL: PMC13162089
DOI: 10.1002/eji.70202
Availability: https://pasteur.hal.science/pasteur-05658763
https://pasteur.hal.science/pasteur-05658763v1/document
https://pasteur.hal.science/pasteur-05658763v1/file/Eur%20J%20Immunol%20-%202026%20-%20Martel%20-%20Nur77%20Is%20Associated%20With%20Polyfunctional%20Properties%20in%20Virus%E2%80%90Specific%20Human%20CD8%20T%20Cells.pdf
https://doi.org/10.1002/eji.70202
Rights: https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess
Accession Number: edsbas.6C130A2C
Database: BASE
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  Data: Nur77 Is Associated With Polyfunctional Properties in Virus‐Specific Human CD8 + T Cells
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  Data: <searchLink fieldCode="AR" term="%22Martel%2C+Fabiola%22">Martel, Fabiola</searchLink><br /><searchLink fieldCode="AR" term="%22Rincón%2C+Daniel%22">Rincón, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Passaes%2C+Caroline%22">Passaes, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Arévalo%2C+Leonardo%22">Arévalo, Leonardo</searchLink><br /><searchLink fieldCode="AR" term="%22Torres%2C+Marcela%22">Torres, Marcela</searchLink><br /><searchLink fieldCode="AR" term="%22Ramirez%2C+Natalia%22">Ramirez, Natalia</searchLink><br /><searchLink fieldCode="AR" term="%22Narváez%2C+Carlos%22">Narváez, Carlos</searchLink><br /><searchLink fieldCode="AR" term="%22Toro%2C+Jessica%22">Toro, Jessica</searchLink><br /><searchLink fieldCode="AR" term="%22Sussmann%2C+Otto%22">Sussmann, Otto</searchLink><br /><searchLink fieldCode="AR" term="%22Franco%2C+Manuel%22">Franco, Manuel</searchLink><br /><searchLink fieldCode="AR" term="%22Mateus%2C+José%22">Mateus, José</searchLink><br /><searchLink fieldCode="AR" term="%22Sidney%2C+John%22">Sidney, John</searchLink><br /><searchLink fieldCode="AR" term="%22Sette%2C+Alessandro%22">Sette, Alessandro</searchLink><br /><searchLink fieldCode="AR" term="%22Sáez-Cirión%2C+Asier%22">Sáez-Cirión, Asier</searchLink><br /><searchLink fieldCode="AR" term="%22Perdomo-Celis%2C+Federico%22">Perdomo-Celis, Federico</searchLink>
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  Data: Pontificia Universidad Javeriana Bogotá, Colombia (PUJ)<br />CellRep (Entreprise)<br />Réservoirs viraux et contrôle immunitaire / Viral reservoirs and immune control<br />Institut Pasteur Paris (IP)-Université Paris Cité (UPCité)<br />HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences<br />Department of Infectious Diseases, Infectoclinicos IPS, Bogotá, Colombia.<br />Universidad Surcolombiana - Université colombienne du sud - South Colombian University (USCO)<br />Clínica Medilaser - Neiva Huila, Colombia (CM)<br />La Jolla Institute for Immunology La Jolla, CA, États-Unis<br />Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R03AI180633 (to F.P.-C.), as well as Vicerrectoría de Investigación, Pontificia Universidad Javeriana (Grant number 20824, to F.P.-C.). F.M. was partially supported by a scholarship from Pontificia Universidad Javeriana.
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  Data: <i>ISSN: 0014-2980</i>.
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  Data: 2026
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  Data: <searchLink fieldCode="DE" term="%22CD8%2B+T+cells%22">CD8+ T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Nur77%22">Nur77</searchLink><br /><searchLink fieldCode="DE" term="%22human%22">human</searchLink><br /><searchLink fieldCode="DE" term="%22memory%22">memory</searchLink><br /><searchLink fieldCode="DE" term="%22polyfunctionality%22">polyfunctionality</searchLink><br /><searchLink fieldCode="DE" term="%22proliferation%22">proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22stem‐like%22">stem‐like</searchLink><br /><searchLink fieldCode="DE" term="%22[SDV]Life+Sciences+[q-bio]%22">[SDV]Life Sciences [q-bio]</searchLink>
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  Data: International audience ; Human CD8 + T cells undergo significant metabolic and transcriptional shifts during activation and differentiation. The orphan nuclear receptor Nur77 plays a role in modulating these processes and has been linked to T cell dysfunction. However, few studies have addressed its role in the memory potential and functionality of human CD8 + T cells. Here, we evaluated the expression of Nur77 in human CD8 + T cells, focusing on its relationship with their differentiation profile and functionality. Our findings indicate that Nur77 is associated with an early‐differentiated, T cell factor 1 + (TCF‐1 + ) memory‐like phenotype in both total and virus‐specific human CD8 + T cells across contexts of acute resolved or chronic viral infection and vaccination. Nur77 expression was associated with cytokine polyfunctionality and increased proliferative capacity in long‐lived antigen‐responsive cells. Moreover, the modulation of Nur77 activity in vitro enhanced the functionality of chronic human immunodeficiency virus (HIV) and hepatitis B virus (HBV)‐specific CD8 + T cells. These results suggest that Nur77 is associated with polyfunctional properties in virus‐specific CD8 + T cell responses in humans. In addition, this study provides insights into novel strategies for enhancing CD8 + T cell functionality in settings of chronic antigen stimulation.
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  Data: info:eu-repo/semantics/altIdentifier/pmid/42117214; PUBMED: 42117214; PUBMEDCENTRAL: PMC13162089
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  Data: 10.1002/eji.70202
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  Data: https://pasteur.hal.science/pasteur-05658763<br />https://pasteur.hal.science/pasteur-05658763v1/document<br />https://pasteur.hal.science/pasteur-05658763v1/file/Eur%20J%20Immunol%20-%202026%20-%20Martel%20-%20Nur77%20Is%20Associated%20With%20Polyfunctional%20Properties%20in%20Virus%E2%80%90Specific%20Human%20CD8%20T%20Cells.pdf<br />https://doi.org/10.1002/eji.70202
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