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PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation

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Τίτλος: PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
Συγγραφείς: Niemann, Matthias, Matern, Benedict M, Spierings, Eric, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity
Έτος έκδοσης: 2024
Θεματικοί όροι: Algorithms, Alleles, Epitopes, T-Lymphocyte/immunology, Graft Rejection/immunology, HLA Antigens/genetics, Histocompatibility Testing/methods, Humans, Organ Transplantation/adverse effects, Tissue Donors, Taverne, Journal Article
Περιγραφή: To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in many cases a transplant cannot be fully matched, due to widespread variation across populations and the hyperpolymorphism of HLA alleles. Mismatches of the HLA molecules in transplanted tissue can be recognized by immune cells of the recipient, leading to immune response and possibly organ rejection. These adverse outcomes are reduced by analysis using epitope-focused models that consider the immune relevance of the mismatched HLA.PIRCHE, an acronym for Predicted Indirectly ReCognizable HLA Epitopes, aims to categorize and quantify HLA mismatches in a patient-donor pair by predicting HLA-derived T cell epitopes. Specifically, the algorithm predicts and counts the HLA-derived peptides that can be presented by the host HLA, known as indirectly-presented T cell epitopes. Looking at the immune-relevant epitopes within HLA allows a more biologically relevant understanding of immune response, and provides an expanded donor pool for a more refined matching strategy compared with allele-level matching. This PIRCHE algorithm is available for analysis of single transplantations, as well as bulk analysis for population studies and statistical analysis for comparison of probability of organ availability and risk profiles.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: text/plain
Γλώσσα: English
ISSN: 1064-3745
Relation: https://dspace.library.uu.nl/handle/1874/453453
Διαθεσιμότητα: https://dspace.library.uu.nl/handle/1874/453453
Rights: info:eu-repo/semantics/OpenAccess
Αριθμός Καταχώρησης: edsbas.6B41DF
Βάση Δεδομένων: BASE
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  Group: Ti
  Data: PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Niemann%2C+Matthias%22">Niemann, Matthias</searchLink><br /><searchLink fieldCode="AR" term="%22Matern%2C+Benedict+M%22">Matern, Benedict M</searchLink><br /><searchLink fieldCode="AR" term="%22Spierings%2C+Eric%22">Spierings, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22CDL+Cluster+Speciële+Diagnostiek%22">CDL Cluster Speciële Diagnostiek</searchLink><br /><searchLink fieldCode="AR" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="AR" term="%22Infection+%26+Immunity%22">Infection & Immunity</searchLink>
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2024
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Algorithms%22">Algorithms</searchLink><br /><searchLink fieldCode="DE" term="%22Alleles%22">Alleles</searchLink><br /><searchLink fieldCode="DE" term="%22Epitopes%22">Epitopes</searchLink><br /><searchLink fieldCode="DE" term="%22T-Lymphocyte%2Fimmunology%22">T-Lymphocyte/immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+Rejection%2Fimmunology%22">Graft Rejection/immunology</searchLink><br /><searchLink fieldCode="DE" term="%22HLA+Antigens%2Fgenetics%22">HLA Antigens/genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Histocompatibility+Testing%2Fmethods%22">Histocompatibility Testing/methods</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Organ+Transplantation%2Fadverse+effects%22">Organ Transplantation/adverse effects</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+Donors%22">Tissue Donors</searchLink><br /><searchLink fieldCode="DE" term="%22Taverne%22">Taverne</searchLink><br /><searchLink fieldCode="DE" term="%22Journal+Article%22">Journal Article</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in many cases a transplant cannot be fully matched, due to widespread variation across populations and the hyperpolymorphism of HLA alleles. Mismatches of the HLA molecules in transplanted tissue can be recognized by immune cells of the recipient, leading to immune response and possibly organ rejection. These adverse outcomes are reduced by analysis using epitope-focused models that consider the immune relevance of the mismatched HLA.PIRCHE, an acronym for Predicted Indirectly ReCognizable HLA Epitopes, aims to categorize and quantify HLA mismatches in a patient-donor pair by predicting HLA-derived T cell epitopes. Specifically, the algorithm predicts and counts the HLA-derived peptides that can be presented by the host HLA, known as indirectly-presented T cell epitopes. Looking at the immune-relevant epitopes within HLA allows a more biologically relevant understanding of immune response, and provides an expanded donor pool for a more refined matching strategy compared with allele-level matching. This PIRCHE algorithm is available for analysis of single transplantations, as well as bulk analysis for population studies and statistical analysis for comparison of probability of organ availability and risk profiles.
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  Data: 1064-3745
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  Data: https://dspace.library.uu.nl/handle/1874/453453
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RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Algorithms
        Type: general
      – SubjectFull: Alleles
        Type: general
      – SubjectFull: Epitopes
        Type: general
      – SubjectFull: T-Lymphocyte/immunology
        Type: general
      – SubjectFull: Graft Rejection/immunology
        Type: general
      – SubjectFull: HLA Antigens/genetics
        Type: general
      – SubjectFull: Histocompatibility Testing/methods
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Organ Transplantation/adverse effects
        Type: general
      – SubjectFull: Tissue Donors
        Type: general
      – SubjectFull: Taverne
        Type: general
      – SubjectFull: Journal Article
        Type: general
    Titles:
      – TitleFull: PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
        Type: main
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            NameFull: Niemann, Matthias
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            NameFull: Matern, Benedict M
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            NameFull: Spierings, Eric
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            NameFull: CDL Cluster Speciële Diagnostiek
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            NameFull: Cancer
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            NameFull: Infection & Immunity
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            – D: 01
              M: 01
              Type: published
              Y: 2024
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