Academic Journal

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
Συγγραφείς: Angus, DC, Derde, L, Al-Beidh, F, Annane, D, Arabi, Y, Beane, A, van Bentum-Puijk, W, Berry, L, Bhimani, Z, Bonten, M, Bradbury, C, Brunkhorst, F, Buxton, M, Buzgau, A, Cheng, AC, de Jong, M, Detry, M, Estcourt, L, Fitzgerald, M, Goossens, H, Green, C, Haniffa, R, Higgins, AM, Horvat, C, Hullegie, SJ, Kruger, P, Lamontagne, F, Lawler, PR, Linstrum, K, Litton, E, Lorenzi, E, Marshall, J, McAuley, D, McGlothin, A, McGuinness, S, McVerry, B, Montgomery, S, Mouncey, P, Murthy, S, Nichol, A, Parke, R, Parker, J, Rowan, K, Sanil, A, Santos, M, Saunders, C, Seymour, C, Turner, A, van de Veerdonk, F, Venkatesh, B, Zarychanski, R, Berry, S, Lewis, RJ, McArthur, C, Webb, SA, Gordon, AC, Writing Committee for the REMAP-CAP Investigators, Angus, D, Cheng, A, De Jong, M, Gordon, A, Lawler, P, Webb, S, Campbell, L, Forbes, A, Gattas, D, Heritier, S, Higgins, L, Peake, S, Presneill, J, Seppelt, I, Trapani, T, Young, P, Bagshaw, S, Daneman, N, Ferguson, N, Misak, C, Hullegie, S, Pletz, M, Rohde, G, Alexander, B, Basile, K, Girard, T, Huang, D, Vates, J, Beasley, R, Fowler, R, McGloughlin, S, Morpeth, S, Paterson, D, Uyeki, T, Baillie, K, Duffy, E, Hills, T, Orr, K, Patanwala, A, Tong, S, Netea, M, Bihari, S, Carrier, M, Fergusson, D, Goligher, E, Haidar, G, Hunt, B, Kumar, A, Laffan, M, Lawless, P, Lother, S, McCallum, P, Middeldopr, S, McQuilten, Z, Neal, M, Pasi, J, Schutgens, R, Stanworth, S, Turgeon, A, Weissman, A, Adhikari, N, Anstey, M, Brant, E, de Man, A, Lamonagne, F, Masse, M-H, Udy, A, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Cooper, J, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, Menon, D, McDyer, J, Pridee, N, Roberts, D, Shankar-Hari, M, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Hodgson, C, Laffey, J, Orford, N, Neto, A, Lewis, R, McGlothlin, A, Miller, E, Singh, V, Zammit, C, van Bentum Puijk, W, Bouwman, W, Mangindaan, Y, Parker, L, Peters, S, Rietveld, I, Raymakers, K, Ganpat, R, Brillinger, N, Markgraf, R, Ainscough, K, Brickell, K, Anjum, A, Lane, J-B, Richards-Belle, A, Saull, M, Wiley, D, Bion, J, Connor, J, Gates, S, Manax, V, van der Poll, T, Reynolds, J, van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Clermont, G, Garrard, W, Kalchthaler, K, King, A, Ricketts, D, Malakoutis, S, Marroquin, O, Music, E, Quinn, K, Cate, H, Pearson, K, Collins, J, Hanson, J, Williams, P, Jackson, S, Asghar, A, Dyas, S, Sutu, M, Murphy, S, Williamson, D, Mguni, N, Potter, A, Porter, D, Goodwin, J, Rook, C, Harrison, S, Williams, H, Campbell, H, Lomme, K, Williamson, J, Sheffield, J, van’t Hoff, W, McCracken, P, Young, M, Board, J, Mart, E, Knott, C, Smith, J, Boschert, C, Affleck, J, Ramanan, M, D’Souza, R, Pateman, K, Shakih, A, Cheung, W, Kol, M, Wong, H, Shah, A, Wagh, A, Simpson, J, Duke, G, Chan, P, Cartner, B, Hunter, S, Laver, R, Shrestha, T, Regli, A, Pellicano, A, McCullough, J, Tallott, M, Kumar, N, Panwar, R, Brinkerhoff, G, Koppen, C, Cazzola, F, Brain, M, Mineall, S, Fischer, R, Biradar, V, Soar, N, White, H, Estensen, K, Morrison, L, Cooper, M, Health, M, Shehabi, Y, Al-Bassam, W, Hulley, A, Whitehead, C, Lowrey, J, Gresha, R, Walsham, J, Meyer, J, Harward, M, Venz, E, Kurenda, C, Smith, K, Smith, M, Garcia, R, Barge, D, Byrne, D, Byrne, K, Driscoll, A, Fortune, L, Janin, P, Yarad, E, Hammond, N, Bass, F, Ashelford, A, Waterson, S, Wedd, S, McNamara, R, Buhr, H, Coles, J, Schweikert, S, Wibrow, B, Rauniyar, R, Myers, E, Fysh, E, Dawda, A, Mevavala, B, Ferrier, J, Nair, P, Buscher, H, Reynolds, C, Santamaria, J, Barbazza, L, Homes, J, Smith, R, Murray, L, Brailsford, J, Forbes, L, Maguire, T, Mariappa, V, Simpson, S, Maiden, M, Bone, A, Horton, M, Salerno, T, Sterba, M, Geng, W, Depuydt, P, De Waele, J, De Bus, L, Fierens, J, Bracke, S, Reeve, B, Dechert, W, Chassé, M, Carrier, FM, Boumahni, D, Benettaib, F, Ghamraoui, A, Bellemare, D, Cloutier, È, Francoeur, C, D’Aragon, F, Carbonneau, E, Leblond, J, Vazquez-Grande, G, Marten, N, Wilson, M, Albert, M, Serri, K, Cavayas, A, Duplaix, M, Williams, V, Rochwerg, B, Karachi, T, Oczkowski, S, Centofanti, J, Millen, T, Duan, E, Tsang, J, Patterson, L, English, S, Watpool, I, Porteous, R, Miezitis, S, McIntyre, L, Brochard, L, Burns, K, Sandhu, G, Khalid, I, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Andric, Z, Cviljevic, S, Đimoti, R, Zapalac, M, Mirković, G, Baršić, B, Kutleša, M, Kotarski, V, Vujaklija Brajković, A, Babel, J, Sever, H, Dragija, L, Kušan, I, Vaara, S, Pettilä, L, Heinonen, J, Kuitunen, A, Karlsson, S, Vahtera, A, Kiiski, H, Ristimäki, S, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Pourcine, F, Monchi, M, Luis, D, Mercier, R, Sagnier, A, Verrier, N, Caplin, C, Siami, S, Aparicio, C, Vautier, S, Jeblaoui, A, Fartoukh, M, Courtin, L, Labbe, V, Leparco, C, Muller, G, Nay, M-A, Kamel, T, Benzekri, D, Jacquier, S, Mercier, E, Chartier, D, Salmon, C, Dequin, P, Schneider, F, Morel, G, L’Hotellier, S, Badie, J, Berdaguer, FD, Malfroy, S, Mezher, C, Bourgoin, C, Megarbane, B, Voicu, S, Deye, N, Malissin, I, Sutterlin, L, Guitton, C, Darreau, C, Landais, M, Chudeau, N, Robert, A, Moine, P, Heming, N, Maxime, V, Bossard, I, Nicholier, TB, Colin, G, Zinzoni, V, Maquigneau, N, Finn, A, Kreß, G, Hoff, U, Friedrich Hinrichs, C, Nee, J, Hagel, S, Ankert, J, Kolanos, S, Bloos, F, Petros, S, Pasieka, B, Kunz, K, Appelt, P, Schütze, B, Kluge, S, Nierhaus, A, Jarczak, D, Roedl, K, Weismann, D, Frey, A, Klinikum Neukölln, V, Reill, L, Distler, M, Maselli, A, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Szigligeti, G, Leszkoven, J, Collins, D, Breen, P, Frohlich, S, Whelan, R, McNicholas, B, Scully, M, Casey, S, Kernan, M, Doran, P, O’Dywer, M, Smyth, M, Hayes, L, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Bosch Ziekenhuis, J, Simons, K, Rozendaal, W, Polderman, F, de Jager, P, Moviat, M, Paling, A, Salet, A, Rademaker, E, Peters, AL, de Jonge, E, Wigbers, J, Guilder, E, Butler, M, Cowdrey, K-A, Newby, L, Chen, Y, Simmonds, C, McConnochie, R, Ritzema Carter, J, Henderson, S, Van Der Heyden, K, Mehrtens, J, Williams, T, Kazemi, A, Song, R, Lai, V, Girijadevi, D, Everitt, R, Russell, R, Hacking, D, Buehner, U, Williams, E, Browne, T, Grimwade, K, Goodson, J, Keet, O, Callender, O, Martynoga, R, Trask, K, Butler, A, Schischka, L, Young, C, Lesona, E, Olatunji, S, Robertson, Y, José, N, Amaro dos Santos Catorze, T, de Lima Pereira, TNA, Neves Pessoa, LM, Castro Ferreira, RM, Pereira Sousa Bastos, JM, Aysel Florescu, S, Stanciu, D, Zaharia, MF, Kosa, AG, Codreanu, D, Marabi, Y, Al Qasim, E, Moneer Hagazy, M, Al Swaidan, L, Arishi, H, Muñoz-Bermúdez, R, Marin-Corral, J, Salazar Degracia, A, Parrilla Gómez, F, Mateo López, MI, Rodriguez Fernandez, J, Cárcel Fernández, S, Carmona Flores, R, León López, R, de la Fuente Martos, C, Allan, A, Polgarova, P, Farahi, N, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Kelsall, O, Wild, L, Thrush, J, Wood, H, Austin, K, Donnelly, A, Kelly, M, O’Kane, S, McClintock, D, Warnock, M, Johnston, P, Gallagher, LJ, Mc Goldrick, C, Mc Master, M, Strzelecka, A, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, Deelchand, V, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Phillips, B, Mullan, D, Oritz-Ruiz de Gordoa, L, Thomas, M, Sweet, K, Grimmer, L, Johnson, R, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Morgan, M, Cole, J, Hill, H, Davies, M, Antcliffe, D, Templeton, M, Rojo, R, Coghlan, P, Smee, J, Mackay, E, Cort, J, Whileman, A, Spencer, T, Spittle, N, Kasipandian, V, Patel, A, Allibone, S, Genetu, RM, Ramali, M, Ghosh, A, Bamford, P, London, E, Cawley, K, Faulkner, M, Jeffrey, H, Smith, T, Brewer, C, Gregory, J, Limb, J, Cowton, A, O’Brien, J, Nikitas, N, Wells, C, Lankester, L, Pulletz, M, Birch, J, Wiseman, S, Horton, S, Alegria, A, Turki, S, Elsefi, T, Crisp, N, Allen, L, McCullagh, I, Robinson, P, Hays, C, Babio-Galan, M, Stevenson, H, Khare, D, Pinder, M, Selvamoni, S, Gopinath, A, Pugh, R, Menzies, D, Mackay, C, Allan, E, Davies, G, Puxty, K, McCue, C, Cathcart, S, Hickey, N, Ireland, J, Yusuff, H, Isgro, G, Brightling, C, Bourne, M, Craner, M, Watters, M, Prout, R, Davies, L, Pegler, S, Kyeremeh, L, Arbane, G, Wilson, K, Gomm, L, Francia, F, Brett, S, Sousa Arias, S, Elin Hall, R, Budd, J, Small, C, Collins, E, Henning, J, Bonner, S, Hugill, K, Cirstea, E, Wilkinson, D, Karlikowski, M, Sutherland, H, Wilhelmsen, E, Woods, J, North, J, Sundaran, D, Hollos, L, Coburn, S, Walsh, J, Turns, M, Hopkins, P, Noble, H, Depante, MT, Clarey, E, Laha, S, Verlander, M, Williams, A, Huckle, A, Hall, A, Cooke, J, Gardiner-Hill, C, Maloney, C, Qureshi, H, Flint, N, Nicholson, S, Southin, S, Nicholson, A, Borgatta, B, Turner-Bone, I, Reddy, A, Wilding, L, Chamara Warnapura, L, Agno Sathianathan, R, Golden, D, Hart, C, Jones, J, Bannard-Smith, J, Henry, J, Birchall, K, Pomeroy, F, Quayle, R, Makowski, A, Misztal, B, Ahmed, I, KyereDiabour, T, Naiker, K, Stewart, R, Mwaura, E, Mew, L, Wren, L, Willams, F, Innes, R, Doble, P, Hutter, J, Shovelton, C, Plumb, B, Szakmany, T, Hamlyn, V, Hawkins, N, Lewis, S, Dell, A, Gopal, S, Ganguly, S, Smallwood, A, Harris, N, Metherell, S, Lazaro, JM, Newman, T, Fletcher, S, Nortje, J, Fottrell-Gould, D, Randell, G, Zaman, M, Elmahi, E, Jones, A, Hall, K, Mills, G, Ryalls, K, Bowler, H, Sall, J, Bourne, R, Borrill, Z, Duncan, T, Lamb, T, Shaw, J, Fox, C, Moreno Cuesta, J, Xavier, K, Purohit, D, Elhassan, M, Bakthavatsalam, D, Rowland, M, Hutton, P, Bashyal, A, Davidson, N, Hird, C, Chhablani, M, Phalod, G, Kirkby, A, Archer, S, Netherton, K, Reschreiter, H, Camsooksai, J, Patch, S, Jenkins, S, Pogson, D, Rose, S, Daly, Z, Brimfield, L, Claridge, H, Parekh, D, Bergin, C, Bates, M, Dasgin, J, McGhee, C, Sim, M, Hay, SK, Phull, M-K, Zaidi, A, Pogreban, T, Rosaroso, LP, Harvey, D, Lowe, B, Meredith, M, Ryan, L, Hormis, A, Walker, R, Collier, D, Kimpton, S, Oakley, S, 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Slevin, K, Lee, S, Hulme, J, Joseph, S, Kinney, F, Senya, HJ, Oborska, A, Kayani, A, Hadebe, B, Orath Prabakaran, R, Nichols, L, Worner, R, Faulkner, B, Gendall, E, Hayes, K, Hamilton-Davies, C, Mfuko, C, Abbass, H, Mandadapu, V, Leaver, S, Forton, D, Patel, K, Paramasivam, E, Powell, M, Gould, R, Wilby, E, Howcroft, C, Banach, D, Fernández de Pinedo Artaraz, Z, Cabreros, L, White, I, Croft, M, Holland, N, Pereira, R, Zaki, A, Johnson, D, Jackson, M, Garrard, H, Juhaz, V, Roy, A, Rostron, A, Woods, L, Cornell, S, Pillai, S, Harford, R, Rees, T, Ivatt, H, Sundara Raman, A, Davey, M, Lee, K, Barber, R, Chablani, M, Brohi, F, Jagannathan, V, Clark, M, Purvis, S, Wetherill, B, Dushianthan, A, Cusack, R, de Courcy-Golder, K, Smith, S, Attwood, B, Parsons, P, Page, V, Zhao, XB, Oza, D, Rhodes, J, Anderson, T, Morris, S, Xia Le Tai, C, Thomas, A, Keen, A, Digby, S, Cowley, N, Southern, D, Reddy, H, Campbell, A, Watkins, C, Smuts, S, Touma, O, Barnes, N, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Bradley-Potts, J, Yates, D, Birkinshaw, I, Kell, K, Marshall, N, Carr-Knott, L
Έτος έκδοσης: 2020
Συλλογή: Queen Mary University of London: Queen Mary Research Online (QMRO)
Θεματικοί όροι: Adrenal Cortex Hormones, Adult, Anti-Inflammatory Agents, Betacoronavirus, Coronavirus Infections, Early Termination of Clinical Trials, Female, Humans, Hydrocortisone, Intensive Care Units, Male, Middle Aged, Pandemics, Pneumonia, Viral, Respiration, Artificial, Shock, Treatment Outcome
Περιγραφή: Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: 1317 - 1329
Γλώσσα: English
Relation: JAMA; https://qmro.qmul.ac.uk/xmlui/handle/123456789/68507
DOI: 10.1001/jama.2020.17022
Διαθεσιμότητα: https://qmro.qmul.ac.uk/xmlui/handle/123456789/68507
https://doi.org/10.1001/jama.2020.17022
Αριθμός Καταχώρησης: edsbas.678003A8
Βάση Δεδομένων: BASE