Academic Journal
Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders
| Τίτλος: | Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders |
|---|---|
| Συγγραφείς: | Hamzaoui, Mouad, Groussard, Deborah, Nezam, Dorian, Djerada, Zoubir, Lamy, Gaspard, Tardif, Virginie, Dumesnil, Anais, Renet, Sylvanie, Brunel, Valery, Peters, Dorien J.M., Chevalier, Laurence, Hanoy, Mélanie, Mulder, Paul, Richard, Vincent, Bellien, Jeremy, Guerrot, Dominique |
| Πηγή: | Hypertension ; volume 79, issue 11, page 2542-2551 ; ISSN 0194-911X 1524-4563 |
| Στοιχεία εκδότη: | Ovid Technologies (Wolters Kluwer Health) |
| Έτος έκδοσης: | 2022 |
| Περιγραφή: | Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary kidney disease and is generally due to mutations in PKD1 and PKD2 , encoding polycystins 1 and 2. In autosomal dominant polycystic kidney disease, hypertension and cardiovascular disorders are highly prevalent, but their mechanisms are partially understood. Methods: Since endothelial cells express the polycystin complex, where it plays a central role in the mechanotransduction of blood flow, we generated a murine model with inducible deletion of Pkd1 in endothelial cells ( Cdh5-Cre ERT2 ; Pkd1 fl/fl ) to specifically determine the role of endothelial polycystin-1 in autosomal dominant polycystic kidney disease. Results: Endothelial deletion of Pkd1 induced endothelial dysfunction, as demonstrated by impaired flow-mediated dilatation of resistance arteries and impaired relaxation to acetylcholine, increased blood pressure and prevented the normal development of arteriovenous fistula. In experimental chronic kidney disease induced by subtotal nephrectomy, endothelial deletion of Pkd1 further aggravated endothelial dysfunction, vascular remodeling, and heart hypertrophy. Conclusions: Altogether, this study provides the first in vivo demonstration that specific deletion of Pkd1 in endothelial cells promotes endothelial dysfunction and hypertension, impairs arteriovenous fistula development, and potentiates the cardiovascular alterations associated with chronic kidney disease. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1161/hypertensionaha.122.19057 |
| DOI: | 10.1161/HYPERTENSIONAHA.122.19057 |
| Διαθεσιμότητα: | https://doi.org/10.1161/hypertensionaha.122.19057 https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.122.19057 |
| Αριθμός Καταχώρησης: | edsbas.657DDDCF |
| Βάση Δεδομένων: | BASE |
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