Academic Journal
View in EDS

Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis

Bibliographic Details
Title: Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis
Authors: Long, Jie, Shang, Tongrui, Mo, Xuezhong, Yu, Yunfang, Lin, Feng, Liang, Zixuan, Monteiro, Olivia, Baptista-Hon, Daniel, Foo, Dominic Chi Chung, Ng, Lui, Liang, Renchuan, Tong, Man, Tang, Weizhong, Zhang, Kang, Huang, Yunxi
Source: Long, J, Shang, T, Mo, X, Yu, Y, Lin, F, Liang, Z, Monteiro, O, Baptista-Hon, D, Foo, D C C, Ng, L, Liang, R, Tong, M, Tang, W, Zhang, K & Huang, Y 2026, 'Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis', MedComm, vol. 7, no. 8, e70871. https://doi.org/10.1002/mco2.70871
Publication Year: 2026
Collection: Discovery - University of Dundee Online Publications
Subject Terms: acoustic reporter genes, chinese medicine curcumin, colorectal cancer, Escherichia coli Nissle 1917, tumor microenvironment, /dk/atira/pure/subjectarea/asjc/2700/2723, name=Immunology and Allergy, /dk/atira/pure/subjectarea/asjc/1300/1311, name=Genetics, /dk/atira/pure/subjectarea/asjc/2700/2730, name=Oncology, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/2700/2716, name=Genetics(clinical), /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology, /dk/atira/pure/subjectarea/asjc/2700/2704, name=Biochemistry, medical
Description: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely due to limitations in early diagnosis and effective treatment. To address these challenges, we developed a multifunctional probiotic nanoplatform, EcNA@Cur-Lip-FA, that integrates real-time diagnosis, targeted therapy, and immune modulation for enhanced CRC treatment. Specifically, this system leverages genetically engineered Escherichia coli Nissle 1917 (EcN) encoding acoustic reporter genes (ARGs) to produce ultrasound (US)-responsive gas vesicles (GVs), enabling real-time, noninvasive tumor imaging. Simultaneously, folic acid (FA)-modified curcumin-loaded liposomes (Cur-Lip-FA) are co-delivered with EcN, enhancing tumor-specific accumulation and therapeutic precision. After being taken up by tumor cells, curcumin is released locally upon exposure to US irradiation, generating reactive oxygen species (ROS), inducing immunogenic cell death (ICD), and activating the cGAS-STING pathway to promote dendritic cells (DCs) maturation and robust CD4 + /CD8 + T-cell responses. Additionally, EcNA@Cur-Lip-FA downregulates angiogenesis-related factors (VEGF, VEGFR1, and ANGPT1), thereby inhibiting tumor neovascularization. In vitro and in vivo studies demonstrated that EcNA@Cur-Lip-FA enables precise tumor localization, dynamic imaging, and effective suppression of both primary CRC and metastatic liver lesions with favorable biocompatibility. This multifunctional platform offers a promising strategy for integrating diagnosis and treatment, paving the way for next-generation CRC theranostics.
Document Type: article in journal/newspaper
File Description: application/pdf
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/42491488
DOI: 10.1002/mco2.70871
Availability: https://discovery.dundee.ac.uk/en/publications/c307c353-3c9c-4932-aa8c-108082e79032
https://doi.org/10.1002/mco2.70871
https://discovery.dundee.ac.uk/ws/files/175934409/MedComm_-_2026_-_Long_-_Genetically_Engineered_Probiotic_Nanoplatform_for_Ultrasound_Enhanced_Colorectal_Cancer_Therapy_via.pdf
https://www.scopus.com/pages/publications/105045197107
Rights: info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.645901AF
Database: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://discovery.dundee.ac.uk/en/publications/c307c353-3c9c-4932-aa8c-108082e79032#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.645901AF
RelevancyScore: 1011
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1010.63568115234
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Long%2C+Jie%22">Long, Jie</searchLink><br /><searchLink fieldCode="AR" term="%22Shang%2C+Tongrui%22">Shang, Tongrui</searchLink><br /><searchLink fieldCode="AR" term="%22Mo%2C+Xuezhong%22">Mo, Xuezhong</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2C+Yunfang%22">Yu, Yunfang</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Feng%22">Lin, Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+Zixuan%22">Liang, Zixuan</searchLink><br /><searchLink fieldCode="AR" term="%22Monteiro%2C+Olivia%22">Monteiro, Olivia</searchLink><br /><searchLink fieldCode="AR" term="%22Baptista-Hon%2C+Daniel%22">Baptista-Hon, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Foo%2C+Dominic+Chi+Chung%22">Foo, Dominic Chi Chung</searchLink><br /><searchLink fieldCode="AR" term="%22Ng%2C+Lui%22">Ng, Lui</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+Renchuan%22">Liang, Renchuan</searchLink><br /><searchLink fieldCode="AR" term="%22Tong%2C+Man%22">Tong, Man</searchLink><br /><searchLink fieldCode="AR" term="%22Tang%2C+Weizhong%22">Tang, Weizhong</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Kang%22">Zhang, Kang</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Yunxi%22">Huang, Yunxi</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Long, J, Shang, T, Mo, X, Yu, Y, Lin, F, Liang, Z, Monteiro, O, Baptista-Hon, D, Foo, D C C, Ng, L, Liang, R, Tong, M, Tang, W, Zhang, K & Huang, Y 2026, 'Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis', MedComm, vol. 7, no. 8, e70871. https://doi.org/10.1002/mco2.70871
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2026
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Discovery - University of Dundee Online Publications
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22acoustic+reporter+genes%22">acoustic reporter genes</searchLink><br /><searchLink fieldCode="DE" term="%22chinese+medicine+curcumin%22">chinese medicine curcumin</searchLink><br /><searchLink fieldCode="DE" term="%22colorectal+cancer%22">colorectal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli+Nissle+1917%22">Escherichia coli Nissle 1917</searchLink><br /><searchLink fieldCode="DE" term="%22tumor+microenvironment%22">tumor microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F2700%2F2723%22">/dk/atira/pure/subjectarea/asjc/2700/2723</searchLink><br /><searchLink fieldCode="DE" term="%22name=Immunology+and+Allergy%22">name=Immunology and Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F1300%2F1311%22">/dk/atira/pure/subjectarea/asjc/1300/1311</searchLink><br /><searchLink fieldCode="DE" term="%22name=Genetics%22">name=Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F2700%2F2730%22">/dk/atira/pure/subjectarea/asjc/2700/2730</searchLink><br /><searchLink fieldCode="DE" term="%22name=Oncology%22">name=Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F3000%2F3002%22">/dk/atira/pure/subjectarea/asjc/3000/3002</searchLink><br /><searchLink fieldCode="DE" term="%22name=Drug+Discovery%22">name=Drug Discovery</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F2700%2F2716%22">/dk/atira/pure/subjectarea/asjc/2700/2716</searchLink><br /><searchLink fieldCode="DE" term="%22name=Genetics%28clinical%29%22">name=Genetics(clinical)</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F1300%2F1307%22">/dk/atira/pure/subjectarea/asjc/1300/1307</searchLink><br /><searchLink fieldCode="DE" term="%22name=Cell+Biology%22">name=Cell Biology</searchLink><br /><searchLink fieldCode="DE" term="%22%2Fdk%2Fatira%2Fpure%2Fsubjectarea%2Fasjc%2F2700%2F2704%22">/dk/atira/pure/subjectarea/asjc/2700/2704</searchLink><br /><searchLink fieldCode="DE" term="%22name=Biochemistry%22">name=Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22medical%22">medical</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely due to limitations in early diagnosis and effective treatment. To address these challenges, we developed a multifunctional probiotic nanoplatform, EcNA@Cur-Lip-FA, that integrates real-time diagnosis, targeted therapy, and immune modulation for enhanced CRC treatment. Specifically, this system leverages genetically engineered Escherichia coli Nissle 1917 (EcN) encoding acoustic reporter genes (ARGs) to produce ultrasound (US)-responsive gas vesicles (GVs), enabling real-time, noninvasive tumor imaging. Simultaneously, folic acid (FA)-modified curcumin-loaded liposomes (Cur-Lip-FA) are co-delivered with EcN, enhancing tumor-specific accumulation and therapeutic precision. After being taken up by tumor cells, curcumin is released locally upon exposure to US irradiation, generating reactive oxygen species (ROS), inducing immunogenic cell death (ICD), and activating the cGAS-STING pathway to promote dendritic cells (DCs) maturation and robust CD4 + /CD8 + T-cell responses. Additionally, EcNA@Cur-Lip-FA downregulates angiogenesis-related factors (VEGF, VEGFR1, and ANGPT1), thereby inhibiting tumor neovascularization. In vitro and in vivo studies demonstrated that EcNA@Cur-Lip-FA enables precise tumor localization, dynamic imaging, and effective suppression of both primary CRC and metastatic liver lesions with favorable biocompatibility. This multifunctional platform offers a promising strategy for integrating diagnosis and treatment, paving the way for next-generation CRC theranostics.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: application/pdf
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: info:eu-repo/semantics/altIdentifier/pmid/42491488
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1002/mco2.70871
– Name: URL
  Label: Availability
  Group: URL
  Data: https://discovery.dundee.ac.uk/en/publications/c307c353-3c9c-4932-aa8c-108082e79032<br />https://doi.org/10.1002/mco2.70871<br />https://discovery.dundee.ac.uk/ws/files/175934409/MedComm_-_2026_-_Long_-_Genetically_Engineered_Probiotic_Nanoplatform_for_Ultrasound_Enhanced_Colorectal_Cancer_Therapy_via.pdf<br />https://www.scopus.com/pages/publications/105045197107
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.645901AF
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.645901AF
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/mco2.70871
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: acoustic reporter genes
        Type: general
      – SubjectFull: chinese medicine curcumin
        Type: general
      – SubjectFull: colorectal cancer
        Type: general
      – SubjectFull: Escherichia coli Nissle 1917
        Type: general
      – SubjectFull: tumor microenvironment
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/2700/2723
        Type: general
      – SubjectFull: name=Immunology and Allergy
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/1300/1311
        Type: general
      – SubjectFull: name=Genetics
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/2700/2730
        Type: general
      – SubjectFull: name=Oncology
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/3000/3002
        Type: general
      – SubjectFull: name=Drug Discovery
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/2700/2716
        Type: general
      – SubjectFull: name=Genetics(clinical)
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/1300/1307
        Type: general
      – SubjectFull: name=Cell Biology
        Type: general
      – SubjectFull: /dk/atira/pure/subjectarea/asjc/2700/2704
        Type: general
      – SubjectFull: name=Biochemistry
        Type: general
      – SubjectFull: medical
        Type: general
    Titles:
      – TitleFull: Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Long, Jie
      – PersonEntity:
          Name:
            NameFull: Shang, Tongrui
      – PersonEntity:
          Name:
            NameFull: Mo, Xuezhong
      – PersonEntity:
          Name:
            NameFull: Yu, Yunfang
      – PersonEntity:
          Name:
            NameFull: Lin, Feng
      – PersonEntity:
          Name:
            NameFull: Liang, Zixuan
      – PersonEntity:
          Name:
            NameFull: Monteiro, Olivia
      – PersonEntity:
          Name:
            NameFull: Baptista-Hon, Daniel
      – PersonEntity:
          Name:
            NameFull: Foo, Dominic Chi Chung
      – PersonEntity:
          Name:
            NameFull: Ng, Lui
      – PersonEntity:
          Name:
            NameFull: Liang, Renchuan
      – PersonEntity:
          Name:
            NameFull: Tong, Man
      – PersonEntity:
          Name:
            NameFull: Tang, Weizhong
      – PersonEntity:
          Name:
            NameFull: Zhang, Kang
      – PersonEntity:
          Name:
            NameFull: Huang, Yunxi
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: Long, J, Shang, T, Mo, X, Yu, Y, Lin, F, Liang, Z, Monteiro, O, Baptista-Hon, D, Foo, D C C, Ng, L, Liang, R, Tong, M, Tang, W, Zhang, K & Huang, Y 2026, 'Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis', MedComm, vol. 7, no. 8, e70871. https://doi.org/10.1002/mco2.70871
              Type: main
ResultId 1