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Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study

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Τίτλος: Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study
Συγγραφείς: Rummel C, Scheffler F, Severino, Mariasavina, Silva LS, Staba RJ, Stein DJ, Striano, Pasquale, Taylor PN, Thomopoulos, Sophia I., Thompson PM, Bender B, Tortora, Domenico, Brioschi R, Vaudano AE, Bürkle E, Weber B, Caligiuri ME, Wiest R, Cendes, Fernando, Winston, Gavin P, de Tisi J, Yasuda CL, Duncan, John S, Engel JP Jr, Foley S, Fortunato F, Kerestes R, Perry A, Vivash, Lucy, O'Brien TJ, Alvim MKM, Arienzo D, Aventurato ÍK, Ballerini A, Baltazar GF, Bargalló Alabart, Núria, Zheng H, McDonald CR, Sisodiya SM, Harding IH, Gambardella, Antonio, Giacomini T, Guerrini, Renzo, Hall G, Hamandi, Khalid, Ives-Deliperi V, João RB, Keller SS, Kleiser B, Labate, Angelo, Lenge, Matteo, Marotta C, Martin, Pascal, Mascalchi M, Meletti S, Owens-Walton C, Parodi CB, Pascual-Diaz, Saül, Powell D, Rao J, Rebsamen M, Reiter J, Riva A, Rüber T
Πηγή: Articles publicats en revistes (Medicina)
Στοιχεία εκδότη: John Wiley & Sons
Έτος έκδοσης: 2024
Συλλογή: Dipòsit Digital de la Universitat de Barcelona
Θεματικοί όροι: Epilèpsia, Cerebel, Imatges per ressonància magnètica, Epilepsy, Cerebellum, Magnetic resonance imaging
Περιγραφή: Objective: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. Methods: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions. Linear mixed models compared total and regional cerebellar volume in (1) all epilepsies, (2) temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), (3) nonlesional temporal lobe epilepsy, (4) genetic generalized epilepsy, and (5) extratemporal focal epilepsy (ETLE). Relationships were examined for cerebellar volume versus age at seizure onset, duration of epilepsy, phenytoin treatment, and cerebral cortical thickness. Results: Across all epilepsies, reduced total cerebellar volume was observed (d = .42). Maximum volume loss was observed in the corpus medullare (dmax = .49) and posterior lobe gray matter regions, including bilateral lobules VIIB (dmax = .47), crus I/II (dmax = .39), VIIIA (dmax = .45), and VIIIB (dmax = .40). Earlier age at seizure onset ( ηρ2max = .05) and longer epilepsy duration ( ηρ2max = .06) correlated with reduced volume in these regions. Findings were most pronounced in TLE-HS and ETLE, with distinct neuroanatomical profiles observed in the posterior lobe. Phenytoin treatment was associated with reduced posterior lobe volume. Cerebellum volume correlated with cerebral cortical thinning more strongly in the epilepsy cohort than in controls. Significance: We provide robust evidence of deep cerebellar and posterior lobe subregional gray matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in nonmotor functions, relative to motor regions of both the anterior and posterior ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: 20 p.; application/pdf
Γλώσσα: English
Relation: Reproducció del document publicat a: https://doi.org/10.1111/epi.17881; Epilepsia Open, 2024; https://doi.org/10.1111/epi.17881; https://hdl.handle.net/2445/226425; 756729
Διαθεσιμότητα: https://hdl.handle.net/2445/226425
Rights: cc-by-nc-nd (c) Kerestes R et al., 2024 ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης: edsbas.62399404
Βάση Δεδομένων: BASE
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  Data: Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study
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  Data: Objective: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. Methods: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions. Linear mixed models compared total and regional cerebellar volume in (1) all epilepsies, (2) temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), (3) nonlesional temporal lobe epilepsy, (4) genetic generalized epilepsy, and (5) extratemporal focal epilepsy (ETLE). Relationships were examined for cerebellar volume versus age at seizure onset, duration of epilepsy, phenytoin treatment, and cerebral cortical thickness. Results: Across all epilepsies, reduced total cerebellar volume was observed (d = .42). Maximum volume loss was observed in the corpus medullare (dmax = .49) and posterior lobe gray matter regions, including bilateral lobules VIIB (dmax = .47), crus I/II (dmax = .39), VIIIA (dmax = .45), and VIIIB (dmax = .40). Earlier age at seizure onset ( ηρ2max = .05) and longer epilepsy duration ( ηρ2max = .06) correlated with reduced volume in these regions. Findings were most pronounced in TLE-HS and ETLE, with distinct neuroanatomical profiles observed in the posterior lobe. Phenytoin treatment was associated with reduced posterior lobe volume. Cerebellum volume correlated with cerebral cortical thinning more strongly in the epilepsy cohort than in controls. Significance: We provide robust evidence of deep cerebellar and posterior lobe subregional gray matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in nonmotor functions, relative to motor regions of both the anterior and posterior ...
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  Data: Reproducció del document publicat a: https://doi.org/10.1111/epi.17881; Epilepsia Open, 2024; https://doi.org/10.1111/epi.17881; https://hdl.handle.net/2445/226425; 756729
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  Data: cc-by-nc-nd (c) Kerestes R et al., 2024 ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess
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      – Text: English
    Subjects:
      – SubjectFull: Epilèpsia
        Type: general
      – SubjectFull: Cerebel
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      – SubjectFull: Imatges per ressonància magnètica
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              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: Articles publicats en revistes (Medicina
              Type: main
ResultId 1